Results 71 to 80 of about 811,356 (270)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Quantifying Near-Threshold CMOS Circuit Robustness [PDF]

, 2014
In order to build energy efficient digital CMOS circuits, the supply voltage must be reduced to near-threshold. Problematically, due to random parameter variation, supply scaling reduces circuit robustness to noise.
Bhargav, Siddharth S., Keller, Sean, Martin, Alain J., Moore, Chris   +3 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Sliding Mode Observer with Adaptive Parameter Estimation for Sensorless Control of IPMSM

Energies, 2020
To improve the observation accuracy and robustness of the sensorless control of an interior permanent magnet synchronous motor (IPMSM), a sliding mode observer based on the super twisting algorithm (STA-SMO) with adaptive parameters estimation control is
Yubo Liu, Junlong Fang, Kezhu Tan, Boyan Huang, Wenshuai He   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Inference robustness in multivariate models with a scale parameter [PDF]

We formulate a general representation of points z 2Regression Analysis;Multivariate Analysis;Statistical Distribution;Scaling ...
Fernández, C., Osiewalski, J., Steel, M.F.J.   +2 more
core   +1 more source

Distributed flow optimization and cascading effects in weighted complex networks

, 2011
We investigate the effect of a specific edge weighting scheme $\sim (k_i k_j)^{\beta}$ on distributed flow efficiency and robustness to cascading failures in scale-free networks. In particular, we analyze a simple, yet fundamental distributed flow model:
A. Asztalos, A. Asztalos, A. Baronchelli, A. Barrat, A. Ghosh, A. Tizghadam, A.E. Motter, A.E. Motter, A.E. Motter, A.K. Chandra, A.L. Barabási, B. Danila, B. Danila, B.K. Szymanski, D.-S. Lee, E. Katifori, E. López, G. Korniss, G. Korniss, G. Korniss, G. Yan, H. Zhao, I. Fatt, J.D. Sachs, J.M. Smith, J.S. Andrade Jr., K. Hu, K.-I. Goh, K.-I. Goh, L. de Arcangelis, L. de Arcangelis, L. de Arcangelis, L.C. Freeman, M. Boguñá, M. Molloy, M. Schäfer, M.-B. Hu, M.E.J. Newman, M.E.J. Newman, M.E.J. Newman, P. Crucitti, P. Erdős, P. Holme, P. Tetali, P.J. MacDonald, P.M. Duxbury, R. Guimerà, R. Kaul, R. Yang, R. Yang, S. Kirkpatrick, S. Sreenivasan, S. Sreenivasan, S.A. Kauffman, U. Brandes, V. Hernandez, W. Ellens, W.-X. Wang, X. Ling, Y. Moreno, Z. Wu   +60 more
core   +1 more source

Robust Estimation of a Location Parameter [PDF]

The Annals of Mathematical Statistics, 1964
This paper contains a new approach toward a theory of robust estimation; it treats in detail the asymptotic theory of estimating a location parameter for contaminated normal distributions, and exhibits estimators—intermediaries between sample mean and sample median—that are asymptotically most robust (in a sense to be specified) among all translation ...
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source