Results 151 to 160 of about 225,085 (221)

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Integrated network toxicology, machine learning algorithms and TMT proteomics reveal the mechanism of 18β glycyrrhetinic acid against gastric cancer. [PDF]

Front Genet
Lu D, Jia S, Li Y, Wang Z, Zhou Z, Liu W, Zhang L, Yuan L, Nan Y.   +8 more
europepmc   +1 more source

Physically consistent mesoscale model evaluation in complex terrain

Quarterly Journal of the Royal Meteorological Society, EarlyView.
This study introduces a novel approach for evaluating mesoscale atmospheric models in complex terrain by selecting physically consistent grid points and applying height‐based corrections. The method corrects for sensor height and terrain elevation differences between model and observations using a time‐varying lapse rate.
Gaspard Simonet, Mathias W. Rotach, Manuela Lehner   +2 more
wiley   +1 more source

PGRF: Physics-Guided Rectified Flow for Low-Light RAW Image Enhancement. [PDF]

J Imaging
Zeng J, Yang Q.
europepmc   +1 more source

Ensemble Kalman filter in latent space using a variational autoencoder pair

Quarterly Journal of the Royal Meteorological Society, EarlyView.
The use of the ensemble Kalman filter (EnKF) in strongly nonlinear or constrained atmospheric, oceanographic, or sea‐ice models can be challenging. Applying the EnKF in the latent space of a variational autoencoder (VAE) ensures that the ensemble members satisfy the balances and constraints present in the model.
Ivo Pasmans, Yumeng Chen, Tobias Sebastian Finn, Marc Bocquet, Alberto Carrassi   +4 more
wiley   +1 more source

CrossDF: improving cross-domain deepfake detection with deep information decomposition. [PDF]

Front Big Data
Yang S, Guo H, Hu S, Zhu B, Fu Y, Lyu S, Wu X, Wang X.   +7 more
europepmc   +1 more source

Impact of small‐scale gravity waves on tracer transport

Quarterly Journal of the Royal Meteorological Society, EarlyView.
We extend a gravity wave (GW) parametrization to calculate the tracer transport due to the GW–Stokes drift and next‐order effects, where the approach is validated by comparing coarse‐resolution simulations with parametrized GWs to high‐resolution, wave‐resolving reference simulations.
Irmgard Knop, Stamen Dolaptchiev, Ulrich Achatz   +2 more
wiley   +1 more source

β-Carotene liposome-based responsive hydrogel inhibits palmitoylation to restore intracellular calcium homeostasis for effective periodontitis treatment. [PDF]

J Nanobiotechnology
Huang S, Li M, Cheng Z, He M, Deng J, Zhang D, Tan M, Ding S, Wu H, Huang L.   +9 more
europepmc   +1 more source

A pilot variational coupled reanalysis based on the CESAM climate model

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Variational data assimilation of in‐situ and satellite ocean data and reanalysis atmospheric data into an intermediate complexity Earth system model is possible by adjusting the surface fluxes and internal model parameters. This pilot application requires nearly complete information on the atmospheric state for synchronization.
Armin Köhl, Iuliia Polkova, Guokun Lyu, Frank Lunkeit, Abhirup Banerjee, Silke Schubert, Detlef Stammer   +6 more
wiley   +1 more source

From Linear Geometry to Nonlinear and Information-Geometric Settings in Test Theory: Bregman Projections as a Unifying Framework. [PDF]

Educ Psychol Meas
Zumbo BD.
europepmc   +1 more source