Results 41 to 50 of about 430,378 (285)

Dynamic PDE parametric curves

open access: yesJournal of Computational and Applied Mathematics, 2008
Dynamic partial differential equation (PDE) parametric curves which can be expressed as a coupled system of two hyperbolic equations are developed. In curve design, dynamic PDE parametric curves can be modified intuitively and are more flexible than ordinary differential equation (ODE) curves. The calculation of dynamic PDE parametric curves must recur
Liu, Xu-Zheng   +4 more
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Quantile Processes for Semi and Nonparametric Regression

open access: yes, 2017
A collection of quantile curves provides a complete picture of conditional distributions. Properly centered and scaled versions of estimated curves at various quantile levels give rise to the so-called quantile regression process (QRP). In this paper, we
Chao, Shih-Kang   +2 more
core   +1 more source

Parametric Curves for Graphic Design Systems [PDF]

open access: yesThe Computer Journal, 1983
One important requirement of a graphic design system is to be able to draw a visually pleasing curve passing through a sequence of discrete points in the Euclidean plane. These points are normally provided as input by the graphic designer or the graphic artist.
Ghosh, P. K., Mudur, S. P.
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Parametric Blending with Geodesic Curves on Triangular Meshes

open access: yesMathematics
This paper presents an effective method for generating blending meshes by leveraging geodesic curves on triangular meshes. Depending on whether the input meshes intersect, the blending regions are automatically initialized using either minimum-distance ...
Seong-Hyeon Kweon   +2 more
doaj   +1 more source

Quick calculation method for fluid flow through duct systems [PDF]

open access: yes, 1970
Conditions for subsonic compressible flow through duct systems are quickly and easily calculated using compact series of curves showing dimensionless parametric functions of Mach number and specific heat ratio.
Scott, L. R., Jr.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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