Results 61 to 70 of about 145,972 (266)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Routing Algorithms with Range Restriction in Sparse Supply Networks

Journal of Algorithms & Computational Technology, 2013
Shortest paths are computed for vehicles with comparatively small maximum range so that they must refuel, recharge or change batteries along a single trip in a road network. Heuristic solutions are given as well as exact algorithms.
Thomas Kämpke
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Fuzzy parameterized extensions of hypersoft set embedded with possibility-degree settings: an overview [PDF]

Neutrosophic Sets and Systems
The Hypersoft set marks a significant advancement in modeling vagueness and uncertainty. Concurrently, fuzzy parameterization and possibility-degree setting have been pivotal.
Atiqe Ur Rahman, Florentin Smarandache, Muhammad Saeed, Khuram Ali Khan   +3 more
doaj   +1 more source

Break detection in the covariance structure of multivariate time series models

, 2008
In this paper, we introduce an asymptotic test procedure to assess the stability of volatilities and cross-volatilites of linear and nonlinear multivariate time series models.
Aue, Alexander, Horváth, Lajos, Hörmann, Siegfried, Reimherr, Matthew   +3 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Non-parametric Bayesian modeling of complex networks

, 2013
Modeling structure in complex networks using Bayesian non-parametrics makes it possible to specify flexible model structures and infer the adequate model complexity from the observed data.
Mørup, Morten, Schmidt, Mikkel N.
core   +1 more source

Approximating Branchwidth on Parametric Extensions of Planarity

The branchwidth of a graph has been introduced by Roberson and Seymour as a measure of the tree-decomposability of a graph, alternative to treewidth. Branchwidth is polynomially computable on planar graphs by the celebrated ``Ratcatcher'' algorithm of Seymour and Thomas. We explore how this algorithm can be extended to minor-closed graph classes beyond
Thilikos, Dimitrios M., Wiederrecht, Sebastian   +1 more
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source