Results 51 to 60 of about 97,834 (258)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

THE INFLUENCE OF AUGMENTED REALITY MEDIA TO IMPROVE UNDERSTANDING CONCEPTS IN SOCIAL STUDIES LEARNING IN ELEMENTARY SCHOOLS

Muallimuna: Jurnal Madrasah Ibtidaiyah
This research aims to determine the effect of using augmented reality media on increasing understanding of social studies learning concepts in elementary schools. This research is a quantitative research with a quasi-experimental design, namely a type of
Nur Fajrina, Ahmad Arifuddin, Heru Mudiyanto   +2 more
doaj   +1 more source

Model Averaging with AIC Weights for Hypothesis Testing of Hormesis at Low Doses

Dose-Response, 2017
For many dose–response studies, large samples are not available. Particularly, when the outcome of interest is binary rather than continuous, a large sample size is required to provide evidence for hormesis at low doses. In a small or moderate sample, we
Steven B. Kim, Nathan Sanders
doaj   +1 more source

General Semiparametric Shared Frailty Model: Estimation and Simulation with frailtySurv

Journal of Statistical Software, 2018
The R package frailtySurv for simulating and fitting semi-parametric shared frailty models is introduced. Package frailtySurv implements semi-parametric consistent estimators for a variety of frailty distributions, including gamma, log-normal, inverse ...
John V. Monaco, Malka Gorfine, Li Hsu
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

PENGARUH PEMBELAJARAN PROJECT BASED LEARNING BERINTEGRASIKAN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) TERHADAP HASIL BELAJAR GEOGRAFI DI SMA NEGERI 1 GORONTALO

Jambura Geo Education Journal, 2021
The influence of science, technology, engineering, and mathematics (STEM) Integrend Learnig Process on the Learning Outcomes of 1 th Grade Student (An Experimental Research Implementend in SMA 1 State Senior  High School if Gorontalo).
Novia Ayu Lestari, Sunarty Suly Eraku, Rusiyah Rusiyah   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Advancements in Laplace transform techniques: Performing non-parametric hypothesis testing on real-world data through statistical analysis

AIP Advances
This research delves into the exploration of a statistical testing approach grounded in Laplace transform techniques specifically tailored for the New Better than Used Laplace transform order (NBUL) class of life distributions.
M. E. Bakr, A. A. El-Toony, Amani Almohaimeed, A. M. Gadallah   +3 more
doaj   +1 more source

Differential mitochondrial toxicity screening and multi-parametric data analysis. [PDF]

PLoS ONE, 2012
Early evaluation of new drug entities for their potential to cause mitochondrial dysfunction is becoming an important task for drug development. Multi-parametric high-content screening (mp-HCS) of mitochondrial toxicity holds promise as a lead in-vitro ...
Maria V Tsiper, Jennifer Sturgis, Larisa V Avramova, Shilpa Parakh, Raymond Fatig, Ana Juan-García, Nianyu Li, Bartek Rajwa, Padma Narayanan, C W Qualls, J Paul Robinson, V Jo Davisson   +11 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source