Results 51 to 60 of about 391,668 (248)

Empirical likelihood test for high-dimensional two-sample model

, 2015
A non parametric method based on the empirical likelihood is proposed for detecting the change in the coefficients of high-dimensional linear model where the number of model variables may increase as the sample size increases. This amounts to testing the
Ciuperca, Gabriela, Salloum, Zahraa
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

THE INFLUENCE OF AUGMENTED REALITY MEDIA TO IMPROVE UNDERSTANDING CONCEPTS IN SOCIAL STUDIES LEARNING IN ELEMENTARY SCHOOLS

Muallimuna: Jurnal Madrasah Ibtidaiyah
This research aims to determine the effect of using augmented reality media on increasing understanding of social studies learning concepts in elementary schools. This research is a quantitative research with a quasi-experimental design, namely a type of
Nur Fajrina, Ahmad Arifuddin, Heru Mudiyanto   +2 more
doaj   +1 more source

Model Averaging with AIC Weights for Hypothesis Testing of Hormesis at Low Doses

Dose-Response, 2017
For many dose–response studies, large samples are not available. Particularly, when the outcome of interest is binary rather than continuous, a large sample size is required to provide evidence for hormesis at low doses. In a small or moderate sample, we
Steven B. Kim, Nathan Sanders
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

PENGARUH PEMBELAJARAN PROJECT BASED LEARNING BERINTEGRASIKAN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) TERHADAP HASIL BELAJAR GEOGRAFI DI SMA NEGERI 1 GORONTALO

Jambura Geo Education Journal, 2021
The influence of science, technology, engineering, and mathematics (STEM) Integrend Learnig Process on the Learning Outcomes of 1 th Grade Student (An Experimental Research Implementend in SMA 1 State Senior  High School if Gorontalo).
Novia Ayu Lestari, Sunarty Suly Eraku, Rusiyah Rusiyah   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Advancements in Laplace transform techniques: Performing non-parametric hypothesis testing on real-world data through statistical analysis

AIP Advances
This research delves into the exploration of a statistical testing approach grounded in Laplace transform techniques specifically tailored for the New Better than Used Laplace transform order (NBUL) class of life distributions.
M. E. Bakr, A. A. El-Toony, Amani Almohaimeed, A. M. Gadallah   +3 more
doaj   +1 more source

Differential mitochondrial toxicity screening and multi-parametric data analysis. [PDF]

PLoS ONE, 2012
Early evaluation of new drug entities for their potential to cause mitochondrial dysfunction is becoming an important task for drug development. Multi-parametric high-content screening (mp-HCS) of mitochondrial toxicity holds promise as a lead in-vitro ...
Maria V Tsiper, Jennifer Sturgis, Larisa V Avramova, Shilpa Parakh, Raymond Fatig, Ana Juan-García, Nianyu Li, Bartek Rajwa, Padma Narayanan, C W Qualls, J Paul Robinson, V Jo Davisson   +11 more
doaj   +1 more source

Soft Null Hypotheses: A Case Study of Image Enhancement Detection in Brain Lesions [PDF]

, 2013
This work is motivated by a study of a population of multiple sclerosis (MS) patients using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to identify active brain lesions.
Crainiceanu, Ciprian M., Liu, Han, Reich, Daniel S., Shinohara, Russell T., Shou, Haochang   +4 more
core   +2 more sources