Results 61 to 70 of about 4,448,452 (248)

Objective Bayes estimation and hypothesis testing : the reference-intrinsic approach [PDF]

, 2005
Conventional frequentist solutions to point estimation and hypothesis testing typically need ad hoc modifications when dealing with non-regular models, and may prove to be misleading.
Juárez, Miguel A.
core  

Hypothesis: Property-Based Testing for Python

, 2021
The "@example(...)" decorator now has a ".via()" method, which future tools will use to track automatically-added covering examples (issue 3506). The canonical version of these notes (with links) is on readthedocs.If you use Hypothesis as part of a ...
MacIver, David R., many other contributors, Hatfield-Dodds, Zac   +2 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Advancements in Laplace transform techniques: Performing non-parametric hypothesis testing on real-world data through statistical analysis

AIP Advances
This research delves into the exploration of a statistical testing approach grounded in Laplace transform techniques specifically tailored for the New Better than Used Laplace transform order (NBUL) class of life distributions.
M. E. Bakr, A. A. El-Toony, Amani Almohaimeed, A. M. Gadallah   +3 more
doaj   +1 more source

Model Averaging with AIC Weights for Hypothesis Testing of Hormesis at Low Doses

Dose-Response, 2017
For many dose–response studies, large samples are not available. Particularly, when the outcome of interest is binary rather than continuous, a large sample size is required to provide evidence for hormesis at low doses. In a small or moderate sample, we
Steven B. Kim, Nathan Sanders
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Hypothesis-testing in competing risks theory.

, 1997
Hypothesis-testing in competing risks ...
Juhui. Jiao (7974824)
core   +4 more sources

General Semiparametric Shared Frailty Model: Estimation and Simulation with frailtySurv

Journal of Statistical Software, 2018
The R package frailtySurv for simulating and fitting semi-parametric shared frailty models is introduced. Package frailtySurv implements semi-parametric consistent estimators for a variety of frailty distributions, including gamma, log-normal, inverse ...
John V. Monaco, Malka Gorfine, Li Hsu
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source