Results 111 to 120 of about 566,253 (298)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Application of Parametric Modeling Techniques for Automated Detailing of Exterior Finishes in Architectural BIM Models: A South Korean Case Study

Buildings
The South Korean government has mandated the use of Building Information Modeling (BIM) as the main medium for design deliverables in public projects.
Sihyun Kim, Min Htet Myint, Youngsu Yu, Wonbok Lee, Tae Wan Kim, Bonsang Koo   +5 more
doaj   +1 more source

Partial and Interaction Spline Models for the Semiparametric Estimation of Functions of Several Variables [PDF]

, 1986
A partial spline model is a model for a response as a function of several variables, which is the sum of a smooth function of several variables and a parametric function of the same plus possibly some other variables.
Wahba, Grace
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Design of a Bidirectional Veneer Defect Repair Method Based on Parametric Modeling and Multi-Objective Optimization

Technologies
Repairing veneer defects is the key to ensuring the quality of plywood. In order to improve the maintenance quality and material utilization efficiency during the maintenance process, this paper proposes a bidirectional maintenance method based on gear ...
Xingchen Ding, Jiuqing Liu, Xin Sun, Hao Chang, Jie Yan, Chengwen Sun, Chunmei Yang   +6 more
doaj   +1 more source

Causal, Bayesian, & non-parametric modeling of the SARS-CoV-2 viral load distribution vs. patient's age. [PDF]

PLoS One, 2022
Guardiani M, Frank P, Kostić A, Edenhofer G, Roth J, Uhlmann B, Enßlin T.   +6 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Robust parametric modeling of Alzheimer's disease progression. [PDF]

Neuroimage, 2021
Mehdipour Ghazi M, Nielsen M, Pai A, Modat M, Jorge Cardoso M, Ourselin S, Sørensen L.   +6 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Bayesian parametric modeling of time to tuberculosis co-infection of HIV/AIDS patients at Jimma Medical Center, Ethiopia. [PDF]

Sci Rep, 2022
Umeta AK, Yermosa SF, Dufera AG.
europepmc   +1 more source