Results 131 to 140 of about 566,253 (298)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Autoregressive parametric modeling combined ANOVA approach for label-free-based cancerous and normal cells discrimination. [PDF]

Heliyon, 2021
AbdulGani AF, Al Ahmad M.
europepmc   +1 more source

Non-parametric and Parametric Modeling of Biodiesel - Sunflower Oil - Crude Oil Price Relationships [PDF]

Multivariate local linear regression and parametric error correction models are applied to assess price linkages and price transmission patterns between food and energy prices in Spain.
Gil, Jose Maria, Hassouneh, Islam, Serra, Teresa   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Automated Generation and Internal Force Visualization for Box Culvert Based on Building Information Modeling

Applied Sciences
Box culverts, as a commonly employed structural form for culverts, play a critical role in traversing topographic barriers, ensuring the safety and smooth operation of transportation means such as roads and railways.
Dejiang Wang, Jiangming Huang
doaj   +1 more source

Radiological assessment schedule for 1p/19q-codeleted gliomas during the surveillance period using parametric modeling. [PDF]

Neurooncol Adv, 2021
Kang H, Lee J, Ji SY, Choi SW, Kim KM, Lee JH, Lee ST, Won JK, Kim TM, Choi SH, Park SH, Moon KS, Kim CY, Yoo H, Nam DH, Kim JH, Kim Y, Park CK.   +17 more
europepmc   +1 more source

Variational Inference of Joint Models using Multivariate Gaussian Convolution Processes

, 2019
We present a non-parametric prognostic framework for individualized event prediction based on joint modeling of both longitudinal and time-to-event data.
Kontar, Raed, Yue, Xubo
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Parametric-modeling-based multi-objective thermoelastic optimization of rudder structures

Mechanics & Industry
Lightweight optimization of rudder structures subjected to thermo-mechanical coupling is essential for high-speed aircraft but poses significant challenges.
Shi Guanghui, Bao Yuhao, Wu Wenhua, Guo Guiqiang, Lin Ye, Zhang Xiaopeng, Tao Ran   +6 more
doaj   +1 more source

Human Thoracolumbar Spine Tolerance to Injury and Mechanisms From Caudo-Cephalad Loading: A Parametric Modeling Study. [PDF]

J Eng Sci Med Diagn Ther, 2021
Yoganandan N, Khandelwal P, Porwal V, Humm J, Banerjee A.   +4 more
europepmc   +1 more source