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Neurologic paraneoplastic syndromes
Journal of the Neurological Sciences, 1998Several neurologic paraneoplastic disorders are believed to be caused by an autoimmune reaction against antigen(s) co-expressed by tumour cells and neurons. Of the paraneoplastic syndromes, the evidence for an autoimmune etiology is strongest for the Lambert-Eaton myasthenic syndrome, in which autoantibodies downregulate voltage-gated calcium channels ...
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Paraneoplastic Neurologic Syndromes
Neurologic Clinics, 2008Paraneoplastic neurologic syndromes (PNS) are mostly immune-mediated disorders that occur in patients with cancer. Because the same neurologic syndromes may occur without a cancer association it is important to know the likelihood of PNS, which is based in part on the syndrome and the patient's demographics and risk factors for cancer.
Myrna R, Rosenfeld, Josep, Dalmau
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Paraneoplastic Neurological Syndrome
Nihon rinsho. Japanese journal of clinical medicine, 2016Paraneoplastic neurological syndrome (PNS) is considered to involve humoral or cellular immunity. Although high titers of onco-neural antibodies against intracellular antigens are generally not pathogenic, cytotoxic T-cell mechanisms are believed to play a role in PNS. In such cases, immunotherapy is only marginally effective.
Takashi Inuzuka +2 more
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Autonomic paraneoplastic neurological syndromes
Autoimmunity Reviews, 2007Autonomic paraneoplastic neurological syndromes (PNS) typically present as chronic gastrointestinal pseudo-obstruction or orthostatic hypotension and usually occur in association with other PNS rather than in isolation. Although rare, they are often debilitating, sometimes fatal, and probably seriously underdiagnosed.
LORUSSO L +5 more
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Neurological paraneoplastic syndromes: an update
Current Opinion in Oncology, 2018Purpose of review To describe recent advances in the diagnosis and treatment of paraneoplastic neurological syndromes (PNS). Recent findings PNS are rare complications of cancer caused by an immune cross-reaction between antigens expressed by tumor cells and neurons.
Berzero G., Psimaras D.
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Paraneoplastic neurological syndromes
Current Opinion in Neurology, 2002This review discusses recent advances and current controversies in the aetiology, investigation and management of paraneoplastic neurological syndromes.Antibody studies continue to define potential target autoantigens in paraneoplastic neurological syndromes and although pathogenic activity has been demonstrated for anti-glutamate receptor antibodies ...
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Paraneoplastic neurologic syndromes
Current Neurology and Neuroscience Reports, 2006Paraneoplastic neurologic disorders (PND) are remote medical complications of cancer that cannot be attributed to direct effects of the neoplasm or its metastases. PND are uncommon, disabling syndromes that have been recognized for more than 50 years.
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Peripheral neurological paraneoplastic syndromes
Drugs of Today, 1998Peripheral neurological paraneoplastic syndromes include some of the most convincingly demonstrated autoimmune disorders. Though rare, they are an important cause of neurological morbidity and mortality, often signaling the presence of an occult tumor.
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[Neurologic paraneoplastic syndromes].
Acta medica portuguesa, 1995Some neurologic syndromes are often associated with neoplasm, as a paraneoplastic disorder. Among them, namely, subacute cerebellar degeneration, sensory neuronopathy, dermatomyositis/polymyositis, Lambert-Eaton myasthenic syndrome and subacute motor neuronopathy, prove sooner or later to be harbouring a neoplasm, therefore a thorough clinical ...
A N, Morganho +3 more
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Paraneoplastic Neurological Syndromes
Cancer Investigation, 1988R, Bashir, F, Hochberg
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