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Paraneoplastic Neurological Syndromes of the Central Nervous System: Pathophysiology, Diagnosis, and Treatment

open access: yesBiomedicines, 2023
Paraneoplastic neurological syndromes (PNS) include any symptomatic and non-metastatic neurological manifestations associated with a neoplasm. PNS associated with antibodies against intracellular antigens, known as “high-risk” antibodies, show frequent ...
Luca Marsili   +5 more
doaj   +5 more sources

Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy [PDF]

open access: yesMolecular Cancer, 2011
Small-cell lung cancer (SCLC) is the most aggressive lung cancer subtype and lacks effective early detection methods and therapies. A number of rare paraneoplastic neurologic autoimmune diseases are strongly associated with SCLC.
Laird-Offringa Ite A, Kazarian Meleeneh
doaj   +3 more sources

Are Onconeural Antibodies a Clinical Phenomenology in Paraneoplastic Limbic Encephalitis? [PDF]

open access: yesMediators of Inflammation, 2013
Paraneoplastic neurological syndromes (PNSs) occur in patients with cancer and can cause clinical symptoms and signs of dysfunction of the nervous system that are not due to a local effect of the tumor or its metastases.
Hongliang Zhang   +5 more
doaj   +4 more sources

Neuroglial markers of damage in autoimmune neurology [PDF]

open access: yesTherapeutic Advances in Neurological Disorders
The advancements in assays for the detection of neuroglial markers of damage, such as neurofilament light chain and glial fibrillary acid protein, have led to a growing interest in their investigation in neurological disorders.
Alessandro Dinoto, Sara Mariotto
doaj   +2 more sources

What to expect from paraneoplastic syndromes of the nervous system in uterine cancer: A review of the literature

open access: yesGynecologic Oncology Reports, 2023
Neurological paraneoplastic syndromes are a rare subgroup of diseases commonly related to neuroendocrine tumors. However, they have been associated with uterine malignancies (sarcomas, endometrial carcinomas, and neuroendocrine cancers).
Anna Svarna   +6 more
doaj   +4 more sources

Neurological Paraneoplastic Syndromes: the Early Diagnosis of Lung Cancer [PDF]

open access: yesModern Medicine, 2022
Paraneoplastic syndromes of the nervous system are rare disorders, strongly linked with lung cancer. This report aims to explore the challenges in the diagnosis and treatment of a patient with early-stage small cell lung cancer and neurological ...
Andreea PAROSANU   +8 more
doaj   +1 more source

Psychiatric manifestations of paraneoplastic syndromes

open access: yesEuropean Psychiatry, 2022
Introduction Paraneoplastic syndromes (PS) result from indirect effects of neoplasms. In 50% of the cases the symptoms precede the diagnosis and run independently.
M. Lemos, A. Lourenço, M. Ribeiro
doaj   +1 more source

Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes

open access: yesAntibodies, 2023
Paraneoplastic antibody syndromes result from the anti-tumor antibody response against normal antigens ectopically expressed by tumor cells. Although this antibody response plays an important role in helping clear a nascent or established tumor, the ...
Daniel Chiu   +2 more
doaj   +1 more source

Paraneoplastic encephalitis associated with renal cell carcinoma [PDF]

open access: yesEncephalitis, 2021
Purpose Paraneoplastic encephalitis is autoimmune encephalitis accompanied by tumors. Renal cell carcinoma (RCC) is a kidney cancer originating from various types of renal cells and rarely has been associated with paraneoplastic neurologic manifestation.
Yoonhyuk Jang   +4 more
doaj   +1 more source

Paraneoplastic neurological syndromes: clinical presentations and management

open access: yesTherapeutic Advances in Neurological Disorders, 2021
We provide an overview of the varied presentations of paraneoplastic neurological syndromes. We also review the onconeural antibodies and their particular oncological and neurological associations.
Michelle F. Devine   +3 more
doaj   +1 more source

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