Results 91 to 100 of about 5,226 (177)

Dynamic changes of paraoxonase 1 activity towards paroxon and phenyl acetate during coronary artery surgery

BMC Cardiovascular Disorders, 2017
Background Serum paraoxonase 1 (PON1), an enzyme associated with high – density lipoproteins (HDL) particles, inhibits the oxidation of serum lipoproteins and cell membranes.
Anna Wysocka, Marek Cybulski, Henryk Berbeć, Andrzej Wysokiński, Janusz Stążka, Jadwiga Daniluk, Tomasz Zapolski   +6 more
doaj   +1 more source

Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: Effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity [PDF]

, 2006
Sub-lethal concentrations of the organophosphate phenyl saligenin phosphate (PSP) inhibited the outgrowth of axon-like processes in differentiating mouse N2a neuroblastoma cells (IC50 2.5 μM).
Abou-Donia, Abou-Donia, Alan J. Hargreaves, Barber, Barber, Brunet, Casida, Chambers, Denizot, Ehrich, El-Fawal, Eto, Flaskos, Flaskos, Forshaw, Fowler, Glynn, Glynn, Gupta, Hatch, Henschler, Ian C. Coutts, James, Jensen, John Flaskos, Johnson, Johnson, Johnson, Jortner, Jortner, Keilbaugh, Laemmli, Lee, Li, Lowry, Magdalini Sachana, Mary Bountouri, Maxine J. Fowler, Nixon, Nomeir, Nomeir, Nostrandt, Nostrandt, Paul Glynn, Perron, Rosenstock, Schmuck, Sharma, Song, Suwita, Towbin, Van Teinhoven, Veeranna, Veronesi, W. Graham McLean, Wayne Harris, Zhao   +56 more
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Paper-based acetylcholinesterase inhibition assay combining a wet system for organophosphate and carbamate pesticides detection [PDF]

, 2015
A dramatic increase in pesticide usage in agriculture highlights the need for on-site monitoring for public health and safety. Here, a paper-based sensor combined with a wet system was developed for the simple and rapid screening of organophosphate (OP ...
Apilux, Amara, Isarankura-Na-Ayudhya, Chartchalerm, Prachayasittikul, Virapong, Tantimongcolwat, Tanawut   +3 more
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Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Molecules, 2009
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and ...
Daniel Jun, Jana Zdarova Karasova, Miroslav Pohanka, Martina Hrabinova, Kamil Musilek, Martin Paar, Vladimir Cirkva, Jiri Palecek, Kamil Kuca, Lucie Musilova   +9 more
doaj   +1 more source

Neuroprotective Effects of N-Acetylcysteine-Amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impairments

Antioxidants
Neurotoxicity induced by organophosphorus (OP) compounds such as paraoxon (POX) leads to severe brain damage and cognitive impairments. Although current treatments alleviate acute cholinergic symptoms, they fail to address secondary neurotoxicity.
Edurne Urquizu, Marine Cuiller, Georgia Papadopoulou, David Pubill, Demetrio Raldúa, Jordi Camarasa, Elena Escubedo, Raul López-Arnau   +7 more
doaj   +1 more source

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Molecules, 2018
Nerve agents and oxon forms of organophosphorus pesticides act as strong irreversible inhibitors of two cholinesterases in the human body: acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8), and are therefore highly ...
Kamil Kuca, Daniel Jun, Lucie Junova, Kamil Musilek, Martina Hrabinova, Jorge Alberto Valle da Silva, Teodorico Castro Ramalho, Marian Valko, Qinghua Wu, Eugenie Nepovimova, Tanos Celmar Costa França   +10 more
doaj   +1 more source

Paraoxonase Activity and Genotype Predispose to Successful Aging [PDF]

, 2017
The paraoxonase 1 codon 192 R allele has been previously reported to have a role in successful aging. The relationship between PON1 genotypes, enzymatic activity, and mass concentration was evaluated in a group of 229 participants from 22 to 104 years of
Boemi, Massimo, Bonfigli, Anna Rita, Cardelli, Maurizio, Cavallone, Luca, Franceschi, Claudio, James, Richard W., Marchegiani, Francesca, Marra, Maurizio, Olivieri, Fabiola, Spazzafumo, Liana   +9 more
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Miotoxicidade por organofosforados

Revista de Saúde Pública, 1996
Os organofosforados são um grupo de compostos químicos amplamente utilizados em agropecuária como inseticidas, ocasionando intoxicações acidentais em animais e humanos, e mesmo sendo utilizados em tentativas de suicídio.
Cavaliere Maria J., Calore Edenilson E., Perez Nilda M., Rodrigues Puga Flávio   +3 more
doaj  

OPTIMIZATION OF PARAOXONASE ORGANOPHOSPHATASE ACTIVITY ASSESSMENT IN MOUSE PLASMA USING PARAOXON-ETHYL [PDF]

Biotechnologia Acta
Aim. To select optimal conditions for determining the organophosphatase activity of paraoxonase in mouse blood plasma using paraoxon-ethyl as a substrate. Materials and Methods. The method was modified from a protocol developed for rats.
Okhovych A.R., Demianchuk O.I., Bayliak M.M.   +2 more
doaj   +1 more source

Caracterização e aplicação de catalisadores sólidos a base de titanato de alumínio dopado com érbio na hidrólise de ésteres de fosfato [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2014.Neste trabalho foram estudadas as propriedades físico-químicas de suportes sólidos em ...
Bueno, Priscila
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