Results 61 to 70 of about 6,578 (194)

Enhancing Crop Nutrition in Arid and Semiarid Regions of Africa Through Genome Editing Using CRISPR/Cas

open access: yesFood and Energy Security, Volume 14, Issue 3, May/June 2025.
ABSTRACT Food insecurity is a pressing issue in Africa, aggravated by escalating drought, jeopardizing the region's ability to meet nutritional requirements for human health. In arid and semiarid regions, crop yield is severely affected by drought and salinity.
Erick Amombo   +5 more
wiley   +1 more source

Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects. [PDF]

open access: yes, 2016
Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of ...
Blackburn, Elizabeth   +5 more
core   +3 more sources

Rewired chromatin structure and epigenetic gene dysregulation during HTLV‐1 infection to leukemogenesis

open access: yesCancer Science, Volume 116, Issue 2, Page 513-523, February 2025.
We analyzed and evaluated cells infected with human T‐cell leukemia virus type 1 at different stages of infection in terms of gene expression and chromatin structure using ATAC sequencing and RNA sequencing. Our results revealed that infected cells exhibited significant changes in gene expression patterns from the polyclonal stage and before adult T ...
Jun Mizuike   +10 more
wiley   +1 more source

Stability and Perpetuation of Human T‐Lymphotropic Virus 1 (HTLV‐1) in Intrafamilial Transmissions of Infection in an Endemic Region of the Brazilian Amazon: A Pilot Study

open access: yesJournal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Introduction Human T‐lymphotropic virus 1 (HTLV‐1) is related to several clinical diseases, including adult T‐cell leukemia/lymphoma and HTLV‐1‐associated myelopathy. Intrafamilial transmission of HTLV‐1 is rarely reported in Brazil and worldwide. Objective To identify HTLV‐1 family transmissions in Belem, Para, the Amazon region of Brazil.
Cássia Cristine Costa Pereira   +9 more
wiley   +1 more source

El Niño-southern oscillations and lathyrism epidemics [PDF]

open access: yes, 2015
Epidemics of lathyrism, a neurological syndrome of spastic paraparesis, have occurredduring severe droughts in Europe, Asia, and Africa for millenia. Causation is linked toexposure to β-N-oxalyl-L-α,β-diaminopropionic acid (β-L-ODAP), a neurotoxin in ...
Olusegun S. A. Oluwole
core   +2 more sources

A State‐of‐the‐Art Review on the Recent Advances in Exosomes in Oncogenic Virus

open access: yesHealth Science Reports, Volume 7, Issue 11, November 2024.
ABSTRACT Background and Aims Oncogenic viruses are responsible for approximately 12% of human malignancies, influencing various cancer processes through intricate interactions with host cells. Exosomes (EXOs), nanometric‐sized microvesicles involved in cell communication, have emerged as critical mediators in these interactions.
Fatemeh Ebrahimi   +3 more
wiley   +1 more source

Status of soluble ST2 levels in serum of HTLV-1 infected individuals [PDF]

open access: yes, 2015
ST2 is a member of IL-1 receptor family expressed on Th2 cells and regulates Th2 responces. The gene of ST2 encodes soluble ST2 (sST2) and the transmembrane ST2 (ST2L) isoforms through alternative mRNA splicing.
Avval, Farnaz Zahedi   +5 more
core   +1 more source

Pathway‐based prediction of the therapeutic effects and mode of action of custom‐made multiherbal medicines

open access: yesMolecular Informatics, Volume 43, Issue 11, November 2024.
Abstract Multiherbal medicines are traditionally used as personalized medicines with custom combinations of crude drugs; however, the mechanisms of multiherbal medicines are unclear. In this study, we developed a novel pathway‐based method to predict therapeutic effects and the mode of action of custom‐made multiherbal medicines using machine learning.
Akihiro Ezoe   +6 more
wiley   +1 more source

The prevalence of hepatitis B virus, human T‐lymphotropic virus and human immunodeficiency virus in patients receiving blood transfusions in South Africa

open access: yesVox Sanguinis, Volume 119, Issue 11, Page 1166-1173, November 2024.
Abstract Background and Objectives South Africa has a high prevalence of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and to a lesser extent human T‐lymphotropic virus (HTLV). Each of these agents is transfusion‐transmissible (TT) but deciding whether to implement preventive screening depends upon knowledge of background prevalence in
Reynier J. Willemse   +6 more
wiley   +1 more source

HTLV-1 antibodies in serum and cerebrospinal fluid in tropical spastic paraparesis in Brazil

open access: yesArquivos de Neuro-Psiquiatria, 1990
HTLV-l antibodies were investigated in serum and in CSF of 150 patients with neurologic disorders mainly myelopathies. The patients were considered into three groups according to the possible relationship of their disease to the presence of HTLV-l ...
A. Spina-França   +7 more
doaj   +1 more source

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