Results 131 to 140 of about 156,706 (215)

Musculoskeletal decay and bone–muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures

Experimental Physiology, EarlyView.
Abstract Older adults experience a markedly increased risk of falls and fractures following hospital discharge, largely due to the rapid musculoskeletal deterioration associated with bed rest. Although age‐related muscle and bone loss typically develops gradually, acute physical inactivity accelerates key biological processes underlying sarcopenia and ...
Julia Margarita Reyes, Guy Hajj‐Boutros, Dounia Rouabhia, José Morais, Felipe Salech, Gustavo Duque   +5 more
wiley   +1 more source

Contact endoscopy for identifying the parathyroid glands during thyroidectomy

, 2010
Aim of this study was to analyse contact endoscopy as an auxiliary method for identifying parathyroid glands during thyroid surgery and to identify other variables that may interfere with this correlation.
GUIMARAES, A. V., DEDIVITIS, R. A., BRANDAO, L. G.   +2 more
core  

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source

Peptide‐Linked Bivalent Nanobody Constructs as Positive Allosteric Modulators of the Calcium‐Sensing Receptor

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 6, December 2026.
ABSTRACT We previously developed nanobodies acting as positive allosteric modulators (PAMs) of the calcium‐sensing receptor (CaSR). Here, we sought to develop more potent CaSR modulators by creating bivalent nanobody constructs using ‘tail‐to‐head’ peptide‐linker conjugation.
Mahdis Nabipour, Charlotte Hagen Skadhauge, Line Juel Rasmussen, Hans Bräuner‐Osborne, Jesper M. Mathiesen, Anders A. Jensen   +5 more
wiley   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3902-3913, November 2026.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

A morphometric ultrastructural study of unenvolved parathyroid glands in primary iperparathyroidism

, 1989
This is a morphometric ultrastructural study with unenvolved parathyroid glands in primary ...
ADAMI, Silvano, LO CASCIO, Vincenzo, Giordani M., Mariam M., Girardi C., Cinti S.   +5 more
core   +1 more source

Body Composition Phenotypes and Their Metabolic Associations in Treatment‐Naïve Patients With Newly Diagnosed Type 2 Diabetes: A DXA‐Based Cluster Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Using dual‐energy X‐ray absorptiometry clustering of 185 treatment‐naïve type 2 diabetes patients, we identified four body‐composition phenotypes. Central‐obesity and high‐fat–high‐muscle clusters carried the highest fatty liver disease and hyperuricemia risk, whereas the low‐muscle cluster carried the highest osteoporosis risk.
Xintong Zhang, Rui Zhang, Tao Jiang
wiley   +1 more source

Pan‐Cancer Landscape of TMEM9 With Experimental Validation in Head and Neck Squamous Cell Carcinoma

The Journal of Gene Medicine, Volume 28, Issue 11, November 2026.
Transmembrane protein 9 (TMEM9) was investigated across cancers using public transcriptomic, clinical, genomic, and immune datasets, followed by functional validation in head and neck squamous cell carcinoma (HNSC). TMEM9 showed cancer‐dependent expression, diagnostic discrimination, prognostic associations, and relationships with immune infiltration ...
Mi Wang, Shangyan Ying, Chunyan Weng, Youfeng Li   +3 more
wiley   +1 more source

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan, Julia Neugebauer, Marcello Bellusci, Enrico Bertini, Garry Brown, Niklas Darin, Suzanne DeBrosse, Lucy Drexler, Stefan Drexler, Gregory M. Enns, Rebecca D. Ganetzky, Kelly Gilbert, Austin Larson, Rebecca Legi, April N. Lehman, Camile Newby, Manuel Schiff, Rachel Skeath, Peter W. Stacpoole, Sarah Thompson, Emma Watt, Saskia B. Wortmann, Jirair K. Bedoyan, Shamima Rahman   +23 more
wiley   +1 more source

Postoperative Hypocalcemia Following Total Thyroidectomy Versus Completion Thyroidectomy

The Laryngoscope, Volume 136, Issue 11, Page 5094-5100, November 2026.
Completion thyroidectomy performed with at least a three‐month interval demonstrates superior parathyroid preservation compared to primary total thyroidectomy, as evidenced by significantly higher postoperative parathyroid hormone levels (51.90 ± 30.26 pg/mL vs. 30.90 ± 17.10 pg/mL, p = 0.006).
Mehmet Turan Cicek, Çiğdem Firat Koca, Mehmet Tan, Baransel Algan   +3 more
wiley   +1 more source