Results 21 to 30 of about 44,736 (232)

Calcitriol-mediated hypercalcemia in a patient with bilateral adrenal non-Hodgkin's B-cell lymphoma case report [PDF]

Journal of Community Hospital Internal Medicine Perspectives, 2016
Calcitriol-mediated hypercalcemia is a frequent manifestation of hematological malignancies. However, there are a few reports of cases presenting with increased angiotensin-converting enzyme (ACE) level, which suggests a possible mechanism similar to ...
Ana Abaroa-Salvatierra, Bilal Shaikh, Mrunalini Deshmukh, Richard Alweis, Arti Patel   +4 more
doaj   +1 more source

Parathyroid Hormone-Related Protein: An Update [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2012
PTHrP was identified as a cause of hypercalcemia in cancer patients 25 yr ago. In the intervening years, we have learned that PTHrP and PTH are encoded by related genes that are part of a larger "PTH gene family." This evolutionary relationship permits them to bind to the same type 1 PTH/PTHrP receptor, which explains why humoral hypercalcemia of ...
openaire   +2 more sources

Hypercalcemia associated with dysgerminoma and elevation of calcitriol: A case report and review of the literature

SAGE Open Medical Case Reports, 2022
We report on the case of a patient with dysgerminoma, a rare germ cell tumor, which showed hypercalcemia with an elevation of 1α,25-dihydroxycholecalciferol (calcitriol). A 27-year-old nulliparous woman presented with hypercalcemia during the examination
Natsuko Hara, Hirotsugu Suwanai, Hironori Abe, Fumiyoshi Yakou, Takuya Ishikawa, Munehiro Urayama, Takeshi Nagai, Toshitaka Nagao, Jumpei Shikuma, Takashi Miwa, Ryo Suzuki, Masato Odawara   +11 more
doaj   +1 more source

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]

, 2012
Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a class A–
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Barwell, James, Upton, Graham J.G., Poyner, David R., Reeves, Philip J., Upton, Graham J. G., Taddese, Bruck, Reeves, Philip J, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Conner, Alex C, Vohra, Shabana, Upton, Graham JG   +16 more
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Hypercalcemia and huge splenomegaly presenting in an elderly patient with B-cell non-Hodgkin's lymphoma: a case report

Journal of Medical Case Reports, 2010
Introduction Hypercalcemia is the major electrolyte abnormality in patients with malignant tumors. It can be due to localized osteolytic hypercalcemia or elaboration of humoral substances such as parathyroid hormone-related protein from tumoral cells. In
Tirgari Farrokh, Pourafkari Marina, Farasat Ebrahim, Daryani Ebrahim, Abasahl Abolghasem, Attarian Shirin, Attarian Hamid, Ghazi Ali AM, Ghazi Siavash M, Kovacs Kalman   +9 more
doaj   +1 more source

Parathyroid hormone related-protein promotes epithelial-to-mesenchymal transition in prostate cancer. [PDF]

PLoS ONE, 2014
Parathyroid hormone-related protein (PTHrP) possesses a variety of physiological and developmental functions and is also known to facilitate the progression of many common cancers, notably their skeletal invasion, primarily by increasing bone resorption.
Weg M Ongkeko, Doug Burton, Alan Kiang, Eric Abhold, Selena Z Kuo, Elham Rahimy, Meng Yang, Robert M Hoffman, Jessica Wang-Rodriguez, Leonard J Deftos   +9 more
doaj   +1 more source

Parathyroid Hormone-Related Protein Promotes Rat Stem Leydig Cell Differentiation

Frontiers in Physiology, 2017
The regulatory factors for stem Leydig cell development are largely unknown. Herein, we reported that parathyroid hormone-related protein (PTHrP) may be a factor to regulate this process.
Tiantian Song, Yiyan Wang, Huitao Li, Lanlan Chen, Jianpeng Liu, Xianwu Chen, Xiaojun Li, Xiaoheng Li, Linxi Li, Qingquan Lian, Ren-Shan Ge, Ren-Shan Ge   +11 more
doaj   +1 more source

Activated effects of parathyroid hormone-related protein on human hepatic stellate cells. [PDF]

PLoS ONE, 2013
BACKGROUND & AIMS: After years of experiments and clinical studies, parathyroid hormone-related protein(PTHrP) has been shown to be a bone formation promoter that elicits rapid effects with limited adverse reaction.
Fen-Fen Liang, Cui-Ping Liu, Li-Xuan Li, Min-Min Xue, Fang Xie, Yu Guo, Lan Bai   +6 more
doaj   +1 more source

Expression of parathyroid hormone‐related protein and the parathyroid hormone/parathyroid hormone‐related protein receptor in rat thymic epithelial cells [PDF]

Journal of Anatomy, 1999
Thymic epithelial cells are an important source of cytokines and other regulatory peptides which guide thymocyte proliferation and maturation. Parathyroid hormone‐related protein (PTHrP), a cytokine‐like peptide, has been reported to affect the proliferation of lymphocytes in vitro. The studies presented here were undertaken to test the hypotheses that
J L, Funk, G V, Jones, C A, Botham, G, Morgan, P, Wooding, M D, Kendall   +5 more
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THE ROLE OF PARATHYROID HORMONE-RELATED PROTEIN IN PATHOGENESIS OF DISORDERS OF BLADDER CONTRACTILE FUNCTION

Кубанский научный медицинский вестник, 2018
Aim. Based on the analysis of the scientific literature sources, the authors aimed to summarize and present the existing information about the role of parathyroid hormone-related protein (PTHrP) in pathogenesis of disorders of bladder contractile ...
V. I. Medvedev, A. N. Kurzanov
doaj   +1 more source