Results 41 to 50 of about 151,592 (317)

SLPI is a critical mediator that controls PTH-induced bone formation

Nature Communications, 2021
The mechanism by which parathyroid hormone mediates the switch from bone resorption to bone formation is unclear. Here, the authors show that SLPI regulates the communication between osteoblasts and osteoclasts to promote the anabolic effect of ...
Akito Morimoto, Junichi Kikuta, Keizo Nishikawa, Takao Sudo, Maki Uenaka, Masayuki Furuya, Tetsuo Hasegawa, Kunihiko Hashimoto, Hiroyuki Tsukazaki, Shigeto Seno, Akira Nakamura, Daisuke Okuzaki, Fuminori Sugihara, Akinori Ninomiya, Takeshi Yoshimura, Ryoko Takao-Kawabata, Hideo Matsuda, Masaru Ishii   +17 more
doaj   +1 more source

Persistent Leukoencephalopathy Following H1N1 Infection Associated With a Novel MYRF Variant (p.Gly735Asp)

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu, Leiyun Huang, Wan Zhu, Min Peng, Qiang Gong, Jing Qian   +5 more
wiley   +1 more source

Functional Integration of Different‐Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis

Advanced Biology, EarlyView.
This study introduces and investigates different‐sex gonad transplants in a mouse model of gender‐affirming hormone therapy. Ovaries and testes implanted into gonadectomized adults exhibit gametogenesis and steroidogenesis independent of the sex of the host.
Daniel R. Pfau, Monica A. Rionda, Evelyn Cho, Jamison G. Clark, Robin E. Kruger, Ruth K. Chan‐Sui, Vasantha Padmanabhan, Molly B. Moravek, Ariella Shikanov   +8 more
wiley   +1 more source

Active vitamin D (1,25-dihydroxyvitamin D) and bone health in middle-aged and elderly men: the European male aging study (EMAS) [PDF]

, 2013
<p>Context: There is little information on the potential impact of serum 1,25-dihydroxyvitamin D [1,25(OH)2D] on bone health including turnover.</p> <p>Objective: The objective of the study was to determine the influence of 1,25(OH ...
Akhter, Aleksander Giwercman, Annesley, Araujo, Bates, Bischoff-Ferrari, Boonen, Boonen, Bouillon, Bouillon, Bouillon, Casetta, Christensen, Cummings, Curtis, David M. Lee, Dirk Vanderschueren, Evelien Gielen, Felipe F. Casanueva, Frank Claessens, Frederick C. W. Wu, Gianni Forti, Gluer, Gyorgy Bartfai, Hannan, Herfarth, Ilpo T. Huhtaniemi, Ivo Jans, Jaak Billen, Jacques, Joseph D. Finn, Judith E. Adams, Kanis, Kate A. Ward, Krzysztof Kula, Kuchuk, Lee, Lee, Lieben, Lips, Lips, Lips, Lips, Lips, Margus Punab, Michael E. J. Lean, Michaël Laurent, Moan, Murphy, Neil Pendleton, Norman, Orwoll, Pye, Quesada, Reid, Reuben, Rudnicki, Saquib, Sherman, Stephen R. Pye, Steven Boonen, Szulc, Terence W. O'Neill, Thang S. Han, Vanderschueren, Vieth, Washburn, Woitge   +67 more
core   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Refractory hypercalcemia caused by parathyroid-hormone-related peptide secretion from a metastatic pancreatic neuroendocrine tumor: a case report

Journal of Medical Case Reports
Background The parathyroid-hormone-related peptide has been shown in earlier studies to be secreted by pancreatic neuroendocrine tumors, although its secretion by gastroenteropancreatic neuroendocrine tumors is very rare.
Motti Haimi, Ji Wei Yang, Richard Kremer
doaj   +1 more source

The relationship between serum 25-hydroxyvitamin D and parathyroid hormone concentration in assessing vitamin D deficiency in pet rabbits

BMC Veterinary Research, 2020
Background Vitamin D deficiency and related metabolic bone diseases in pet rabbits have been intermittently debated. In human research, the parathyroid hormone concentration in relation to the 25-hydroxyvitamin D concentration is used to determine ...
J. Mäkitaipale, S. Sankari, H. Sievänen, O. Laitinen-Vapaavuori   +3 more
doaj   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

Differentiation of Rat Adipose-Derived Stem Cells into Parathyroid-Like Cells

International Journal of Endocrinology, 2020
Background. The current treatment for postoperative hypoparathyroidism has shortcomings, such as repeated blood monitoring for dosage adjustment, uncertain long-term efficacy, and the high price of recombinant parathyroid hormone therapy. Adipose-derived
Ping Zhang, Hao Zhang, Wenwu Dong, Zhihong Wang, Yuan Qin, Changhao Wu, Qi Dong   +6 more
doaj   +1 more source

Interaction between serum FGF-23 and PTH in renal phosphate excretion, a case-control study in hypoparathyroid patients

BMC Nephrology, 2020
Background phosphate homeostasis is mediated through complex counter regulatory feed-back balance between parathyroid hormone, FGF-23 and 1,25(OH)2D. Both parathyroid hormone and FGF-23 regulate proximal tubular phosphate excretion through signaling on ...
Forough Saki, Seyed Reza Kassaee, Azita Salehifar, Gholam Hossein Ranjbar Omrani   +3 more
doaj   +1 more source