Results 141 to 150 of about 26,295 (289)

Synergistic associations of metformin and GLP‐1 receptor agonist use with adiposity‐related cancer incidence in people living with type 2 diabetes

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 946-959, February 2026.
Abstract Background Metformin and glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) may reduce the risk of adiposity‐related cancers in patients with type 2 diabetes (T2D). The potential synergistic effects of these treatments on cancer incidence remain unclear, considering their distinct biological mechanisms and their associated effects on body ...
Alex E. Henney   +6 more
wiley   +1 more source

Lysophosphatidic Acid Synergizes With 1,25‐Dihydroxyvitamin D to Promote Fibroblast Growth Factor‐23 Synthesis via MAPK Signaling and Induction of the IL12A Gene

open access: yesThe FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Ay et al. investigated the cellular mechanisms behind the role of lysophosphatidic acid (LPA) in FGF23 production. They revealed that LPA cooperates with 1,25‐dihydroxyvitamin D (1,25D), that is, the bioactive form of vitamin D known to stimulate FGF23 synthesis. This synergy entails MAPK signaling and the induction of the gene encoding the interleukin‐
Birol Ay   +7 more
wiley   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

open access: yesFEBS Letters, Volume 600, Issue 2, Page 140-163, January 2026.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 2, 14 January 2026.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo   +3 more
wiley   +1 more source

A Giant Parathyroid Adenoma Presenting as Coughs and Dyspnea in a Young Woman: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT A parathyroid adenoma is defined as a benign tumor in the parathyroid glands. A type of parathyroid adenoma is giant parathyroid adenoma that weighs > 3.5 g and has a size of more than 2 cm. A 37‐year‐old woman presented with coughs and dyspnea without fever, hemoptysis, and weight loss. Examination of the patient revealed a diffusely enlarged
Somayeh Chahkandi   +3 more
wiley   +1 more source

Osteitis Fibrosa Cystica: An Unusual Cause of Left-Sided Chest Pain. [PDF]

open access: yesCase Rep Nephrol
We report a case of osteitis fibrosa cystica resulting from secondary hyperparathyroidism in a 21‐year‐old male patient with end‐stage renal disease. The patient presented with persistent, moderate chest pain localized to the left fifth and sixth ribs for eight months. A chest X‐ray revealed well‐defined, expansile lytic lesions in these ribs.
Habib R, Anjum M, Mahmood A, Rizvi N.
europepmc   +2 more sources

Burosumab in Unidentifiable Tumor‐Induced Osteomalacia

open access: yesClinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Tumor‐induced osteomalacia (TIO) can be challenging due to underlying tumors being either unresectable or unidentifiable. Burosumab, an anti‐FGF23 monoclonal antibody, has been proven to be effective in treating TIO but is currently not subsidized for this indication in Australia.
Yi Shan Der   +5 more
wiley   +1 more source

Genetics and Cancer [PDF]

open access: yes, 1977
The existence of a relationship between cancer and heredity has been recognized for years, but only recently has emerging knowledge in this area enabled physicians to detect and treat cancer earlier in affected individuals and to prevent its occurrence ...
Diasio, Robert B., Mueller, John M.
core   +1 more source

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