A late diagnosis of MEN 1 Syndrome in a young patient initially pre-senting with nephrolithiasis
Liječnički vjesnik, 2023 Multiple Endocrine Neoplasms Type 1 (MEN 1), originally called Wermer Syndrome, is a rare hereditary condition caused by mutations in the MEN1 tumor suppressor gene.
Ana Čala, Tina Dušek
doaj +1 more source
Mathematical models for order of mutation problem in myeloproliferative neoplasm: non-additivity and non-commutativity [PDF]
arXiv, 2023 In some patients of myeloproliferative neoplasm, two genetic mutations can be found: JAK2 V617F and TET2. When one mutation is present or not, the other mutation has different effects on regulating gene expressions. Besides, when both mutations are present, the order of occurrence might make a difference.
arxiv
Senescent cells: A therapeutic target for osteoporosis
Cell Proliferation, Volume 55, Issue 12, December 2022., 2022 Bone is a metabolically active tissue involved in physiological processes of locomotion, support and protection of soft tissues, calcium and phosphate storage, and harbouring of bone marrow. Bone is constituted by various types of cells undergoing continuous remodelling.
Tiantian Wang, Shishu Huang, Chengqi He
wiley +1 more source
Ectopic Mediastinal Parathyroid Adenoma in a Patient with Chronic Kidney Disease: A Case Report
대한영상의학회지, 2019 We report an ectopic mediastinal parathyroid adenoma in a patient with chronic kidney disease who presented with refractory hypercalcemia. Technetium-99m-sestamibi scintigraphy is a valuable imaging technique for the detection of an ectopic parathyroid ...
Dong Min Choo +2 more
doaj +1 more source
Order-of-mutation effects on cancer progression: models for myeloproliferative neoplasm [PDF]
arXiv, 2023 We develop a modeling framework for cancer progression that distinguishes the order of two possible mutations. Recent observations and information on myeloproliferative neoplasms are analyzed within our framework. In some patients with myeloproliferative neoplasms, two genetic mutations can be found, JAK2 V617F and TET2.
arxiv
Towards Understanding the Survival of Patients with High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms: An Investigation of Ensemble Feature Selection in the Prediction of Overall Survival [PDF]
, 2023 Determining the most informative features for predicting the overall survival of patients diagnosed with high-grade gastroenteropancreatic neuroendocrine neoplasms is crucial to improve individual treatment plans for patients, as well as the biological understanding of the disease. Recently developed ensemble feature selectors like the Repeated Elastic
arxiv +1 more source
Generalized-Ensemble Simulations of the Human Parathyroid Hormone Fragment PTH(1-34) [PDF]
, 2003 A generalized-ensemble technique, multicanonical sampling, is used to study the folding of a 34-residue human parathyroid hormone fragment. An all-atom model of the peptide is employed and the protein-solvent interactions are approximated by an implicit solvent. Our results demonstrate that generalized-ensemble simulations are well suited to sample low-
arxiv +1 more source
BlazeNeo: Blazing fast polyp segmentation and neoplasm detection [PDF]
arXiv, 2022 In recent years, computer-aided automatic polyp segmentation and neoplasm detection have been an emerging topic in medical image analysis, providing valuable support to colonoscopy procedures. Attentions have been paid to improving the accuracy of polyp detection and segmentation.
arxiv
Thyroid nodules in children and adolescents: Investigation and management
Journal of Paediatrics and Child Health, Volume 58, Issue 12, Page 2163-2168, December 2022., 2022 Clinically detectable thyroid nodules are less common in children than adults. However, they are associated with an increased risk of malignancy. Therefore, thorough evaluation of paediatric thyroid nodules is necessary, and an understanding of the features associated with a higher risk of malignancy is important to guide management and referral ...
Jessica L Sandy +5 more
wiley +1 more source
Polish Journal of Pathology, 2021 Discriminating thyroid and parathyroid lesions may sometimes pose a diagnostic difficulty. Medullary thyroid carcinomas (MTCs) display various cytologic and architectural features that resemble other thyroid and even rarely some parathyroid neoplasms ...
Sarah Adel Hakim +1 more
doaj +1 more source