No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms [PDF]
, 1933 G-Proteins are membrane-bound heterotrimeric polypeptides that couple receptor signals to second messenger systems such as cAMP. Recently, point mutations at 2 codons of the highly preserved alpha-chain of Gs, the adenyl cyclase-stimulating G-protein ...
Chrousos, G. P. +3 more
core
Implantable Drug Delivery Systems for Skeletal Muscles and Eyes
Advanced NanoBiomed Research, EarlyView.This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov +8 more
wiley +1 more source
Severe Hypercalcemia and Confusion in a Middle-Aged Male: The Hidden Diagnosis of Parathyroid Carcinoma. [PDF]
Case Rep EndocrinolParathyroid cancer (PC) is one of the rarest causes of primary hyperparathyroidism (PHPT), typically exhibiting an indolent course but presenting with more severe symptoms compared to its benign counterparts. The diagnosis is most often made postoperatively through histopathological examination; however, certain clinical and biochemical features may ...
Fahmi H +4 more
europepmc +2 more sources
Treatment options for PNET liver metastases. a systematic review [PDF]
, 2018 Pancreatic neuroendocrine tumors (PNETs) are rare pancreatic neoplasms. About 40-80% of patients with PNET are metastatic at presentation, usually involving the liver (40-93%). Liver metastasis represents the most significant prognostic factor.
Aurello, Paolo +8 more
core +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Large parathyroid adenomas: Potential mechanisms to reconcile adenoma size and disease phenotype
Frontiers in Endocrinology, 2023 Parathyroid adenomas weighing more than 3.5 g are reported variously as “atypical”, “large” or “giant” parathyroid adenomas. All such adenomas are rare variants accounting for no more than 1.5% of all parathyroid adenomas.
Arti Bhan +8 more
doaj +1 more source
Primary Hyperparathyroidism With Brown Tumor—A Case Mistaken as Non‐Ossifying Fibroma Resolved by Biochemical and Radiological Correlation [PDF]
Clin Case RepABSTRACT Primary hyperparathyroidism (PHPT) is uncommon in the pediatric population and rarely presents with overt skeletal complications such as brown tumors. This case study describes a 16‐year‐old female who initially presented with abdominal pain and was subsequently found to have severe hypercalcemia (serum calcium 16.4 mg/dL) and markedly ...
Regmi D +4 more
europepmc +2 more sources
Neuroendocrine Tumors (NETs) : A population-based study of incidence and survival in Girona province, 1994-2004 [PDF]
, 2012 Els tumors neuroendocrins (TNEs) són un grup de neoplàsies poc freqüents i heterogènies i amb un ampli espectre d'agressivitat. Hi ha molt poca informació epidemiològica a nivell mundial, l'objectiu d'aquest estudi ha estat el de reportar-ne les dades a ...
Alsina Maqueda, Maria +3 more
core
Preoperative Detection of Dual TERT Promoter Mutations in Thyroid Cancer: A Case Series
Diagnostic Cytopathology, EarlyView.ABSTRACT Telomerase reverse transcriptase promoter (TERTp) mutations are associated with aggressive thyroid cancer and are most frequently found in anaplastic and poorly differentiated thyroid cancer. Pre‐operative thyroid nodule molecular testing can detect TERTp, denoting a high risk of malignancy and possible aggressive clinical features such as ...
Amir Harari +7 more
wiley +1 more source
Journal of Medical Case Reports, 2017 Background Atypical carcinoid arising from the mediastinal tissue is a rare neuroendocrine tumor and an association with parathyroid adenoma is very unusual.
Zareen Kiran +6 more
doaj +1 more source