Viral Paratransgenesis in the Malaria Vector Anopheles gambiae [PDF]
PLoS Pathogens, 2008 Paratransgenesis, the genetic manipulation of insect symbiotic microorganisms, is being considered as a potential method to control vector-borne diseases such as malaria.
Jason L Rasgon, Xiaoxia Ren
exaly +4 more sources
Diversity and Species Composition of Midgut Symbiotic Bacteria in Culex quinquefasciatus Mosquitoes in Gampaha District, Sri Lanka [PDF]
Journal of Tropical MedicineMosquitoes, notorious for their deadly impact as disease vectors, also hold economic value owing to their roles in disease transmission. The present study focuses on the importance of understanding mosquito gut microbiota for implementing innovative ...
Randi Hathnagoda +6 more
doaj +3 more sources
Assessing Survival of Transgenic Bacteria, Serratia AS1 and Enterobacter cloacae, in Sugar Bait, White Saxaul Plant (Haloxylon persicum) and Rodent Barrow’s Soil, A Contained-Field Study for Paratransgenesis Approach [PDF]
Journal of Arthropod-Borne DiseasesBackground: The viability and persistence of engineered bacterium candidates in field conditions is one of the considerable challenges in the paratransgenesis approach to fighting vector-borne diseases.
Marzieh Ghassemi +6 more
doaj +4 more sources
Characterization of the Tissue and Strain-Specific Microbiota of Anopheles funestus Giles (Diptera: Culicidae) [PDF]
Tropical Medicine and Infectious DiseaseThe mosquito microbiota is a critical determinant of mosquito life history. It is therefore a target for novel vector control strategies like paratransgenesis.
Chia-Yu Chen +3 more
doaj +3 more sources
Inhibition of Plasmodium berghei Development in Mosquitoes by Effector Proteins Secreted from Asaia sp. Bacteria Using a Novel Native Secretion Signal. [PDF]
PLoS ONE, 2015 Novel interventions are needed to prevent the transmission of the Plasmodium parasites that cause malaria. One possible method is to supply mosquitoes with antiplasmodial effector proteins from bacteria by paratransgenesis.
Nicholas J Bongio, David J Lampe
doaj +2 more sources
An evaluation of fusion partner proteins for paratransgenesis in Asaia bogorensis.
PLoS ONE, 2022 Mosquitoes transmit many pathogens responsible for human diseases, such as malaria which is caused by parasites in the genus Plasmodium. Current strategies to control vector-transmitted diseases are increasingly undermined by mosquito and pathogen ...
Christina Grogan +2 more
doaj +2 more sources
The Effect of Larval Exposure to Heavy Metals on the Gut Microbiota Composition of Adult Anopheles arabiensis (Diptera: Culicidae) [PDF]
Tropical Medicine and Infectious DiseaseAnopheles arabiensis is a highly adaptable member of the An. gambiae complex. Its flexible resting behaviour and diverse feeding habits make conventional vector control methods less effective in controlling this species. Another emerging challenge is its
Ashmika Singh +6 more
doaj +2 more sources
Determinants of Human African Trypanosomiasis Elimination via Paratransgenesis. [PDF]
PLoS Neglected Tropical Diseases, 2016 Human African trypanosomiasis (HAT), transmitted by tsetse flies, has historically infected hundreds of thousands of individuals annually in sub-Saharan Africa.
Jennifer A Gilbert +5 more
doaj +2 more sources
Frontiers in Ecology and Evolution, 2018 Since bacterial symbionts play a vital role in the metabolism of hematophagous insect vectors the method known as paratrangenesis, which consists of the use of cultivable insect symbionts to interfere with the transmission of vector-transmitted pathogens
Teresa Lopez-Ordonez +4 more
doaj +2 more sources
BMC Microbiology, 2018 Background Tsetse flies (Diptera: Glossinidae) are the cyclical vectors of the causative agents of African Trypanosomosis, which has been identified as a neglected tropical disease in both humans and animals in many regions of sub-Saharan Africa.
Güler Demirbas-Uzel +6 more
doaj +2 more sources