Results 31 to 40 of about 3,822 (259)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Modelling the optimal delivery of spare parts to vessels: Comparison of three different scenarios

Cogent Engineering, 2021
Spare parts management on ships is a notable segment of total transportation costs being able to become a significant factor in the process of cost optimization, given the increasingly unpredictable economic circumstances and unstable geopolitical ...
Luka Vukić, Ladislav Stazić, Marija Pijaca, Ivan Peronja   +3 more
doaj   +1 more source

Optimization of Truck-Drone Parcel Delivery Using Metaheuristics

Applied Sciences, 2021
This research addresses a variant of the traveling salesman problem in drone-based delivery systems known as the TSP-D. The TSP-D is a combinatorial optimization problem in which a truck and a drone collaborate to deliver parcels to customers, with the ...
Sarab AlMuhaideb, Taghreed Alhussan, Sara Alamri, Yara Altwaijry, Lujain Aljarbou, Haifa Alrayes   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Innovative scenarios for modeling intra-city freight delivery

Transportation Research Interdisciplinary Perspectives, 2019
There has been a shift in the focus of freight modeling to the short-haul (or last-mile) due to an increase in online shopping. This study considers innovative freight delivery modes and multi-modal shifts, especially for the last-mile portion of intra ...
Amy M. Moore
doaj   +1 more source

Effects of Parcel Delivery Service on Customer Satisfaction in the Saudi Arabian Logistics Industry: Does the National Culture Make a Difference?

Logistics, 2023
Background: The logistics industry is keen to meet customer expectations, which in turn supports trade by enhancing business competitiveness and promoting economic development.
Abu Elnasr E. Sobaih, Ahmed AlSaif
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Assessing consumer adoption of smart lockers for sustainable e-commerce delivery

Cleaner Logistics and Supply Chain
The growth of e-commerce has intensified last-mile delivery challenges, including failed deliveries, repeated delivery attempts, and fragmented parcel flows.
Chi-Chang Lin, Zaili Yang, Chia-Hsun Chang   +2 more
doaj   +1 more source

Parcel Classification and Positioning of Intelligent Parcel Storage System Based on YOLOv5

Applied Sciences, 2022
Parcel storage provides last-mile delivery services as part of the logistics process. In order to build an intelligent system for parcel storage, we conducted a study on parcel box recognition using AI’s deep learning technology.
Mirye Kim, Youngmin Kim
doaj   +1 more source