Results 41 to 50 of about 3,707 (258)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Model for Crowdsourced Parcel Delivery Embedded into Mobility as a Service Based on Autonomous Electric Vehicles

Energies, 2021
Faced promising development of autonomous vehicles, the concept Mobility as a Service embraces AVs. The autonomous delivery has also been arising and tested for last-mile solution.
Yinying He, Csaba Csiszár
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A Review of Literature on Vehicle Routing Problems of Last-Mile Delivery in Urban Areas

Applied Sciences, 2023
Logistics has long been important in an industrial society. Compared with the traditional structure of distribution, which requires freight to be delivered mostly to warehouses or retail stores, customers now often prefer packages to be delivered to ...
Reza Jazemi, Ensieh Alidadiani, Kwangseog Ahn, Jaejin Jang   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Analysis of User Attitudes and Behavior in the Context of Traditional Delivery and the Use of Parcel Lockers

Logistics
Background: The rapid development of e-commerce has led to significant changes in last-mile logistics, where innovative delivery solutions such as parcel lockers are increasingly considered to improve efficiency and flexibility.
Sreten Simović, Tijana Ivanišević, Aleksandar Trifunović   +2 more
doaj   +1 more source

A Robust Optimization Method for Location Selection of Parcel Lockers under Uncertain Demands

Mathematics, 2022
Parcel lockers have continuously growing in popularity as an alternative mode for last-mile delivery services due to their capability of effectively alleviating the risk of a delivery failure, increasing the possibility of delivery consolidation, and ...
Yang Wang, Yumeng Zhang, Mengyu Bi, Jianhui Lai, Yanyan Chen   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Parcel Transportation and Delivery Mechanism for an Indoor Omnidirectional Robot

Applied Sciences
Parcel transportation is a task that is expected to be highly automated with the development of application-specific mobile robots. This paper presents the design and implementation of a parcel transportation and delivery mechanism aimed at converting a ...
Elena Rubies, Ricard Bitriá, Jordi Palacín   +2 more
doaj   +1 more source