Results 51 to 60 of about 3,822 (259)

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Drone scheduling for parcel delivery with an access grade to stops on a fixed truck route

Journal of Advanced Mechanical Design, Systems, and Manufacturing
In this paper, we consider a parcel delivery scheduling problem of minimizing the total duration for a truck-drone distribution system to serve a given set of customers.
Kotaro YAMADA, Yoshiyuki KARUNO, Riki KATAOKA, Sota SAWADA   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Using drones for parcels delivery process

Procedia Manufacturing, 2020
Parcels delivery is the most expensive phase of the distribution logistics. Everyday, several vehicles, usually internal combustion engine vehicles, have to serve a high number of customers spatially distributed in an urban area. Their presence generates several negative externalities, such as, noise, congestion and pollutant emissions.
Di Puglia Pugliese L., Guerriero F., Macrina G.   +2 more
openaire   +4 more sources

Paying for Free Delivery: Dependent Self-Employment as a Measure of Precarity in Parcel Delivery [PDF]

Work, Employment and Society, 2018
This article explores supply chain pressures in parcel delivery and how the drive to contain costs to ‘preserve value in motion’, including the costs of failed delivery, underpins contractual differentiation. It focuses on owner-drivers and home couriers paid by delivery.
Moore, S., Newsome, K.J.
openaire   +3 more sources

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Crowdsourcing Incentives for Multi-Hop Urban Parcel Delivery Network

IEEE Access, 2019
Efficient and economic parcel delivery becomes a key factor in the success of online shopping. Addressing this challenge, this paper proposes to crowdsource the parcel delivery task to urban vehicles to utilize their spare capacities, thus improving the ...
Huiting Hong, Xin Li, Daqing He, Yiwei Zhang, Mingzhong Wang   +4 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Drivers of consumers’ adoption of parcel lockers as an alternative last-mile delivery solution in emerging economies

Transportation Research Interdisciplinary Perspectives
The sustained growth of online sales has increased pressure on urban logistics systems, especially last-mile operations. The freight traffic generated by parcel deliveries creates negative social, environmental, and economic externalities.
Paula Penagos, Trilce Encarnación, Carlos A. Gonzalez-Calderon   +2 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source