Results 101 to 110 of about 2,189,457 (236)

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

The Role of Attachment in Emotional Support Provision in Adult Child–Parent Relationships: A Dyadic Response Surface Analysis

Behavioral Sciences
The adult child–parent relationship is a key source of emotional support across adulthood and older age. This study takes a dyadic, attachment-based perspective to examine how (dis)similarities in attachment orientations between older parents and adult ...
Ella Carasso, Dikla Segel-Karpas, Roi Estlein   +2 more
doaj   +1 more source

Whanau Whakapakari: a Māori-centred approach to child rearing and Parent-training programmes [PDF]

, 2001
The goal of this Whanau Whakapakari (Strengthening Families) research was to define critical aspects of Māori experiences and views on child-rearing practices, and to describe whanau (extended family) values and expectations for tamariki (children) and ...
Herbert, Averil May Lloyd
core  

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Can transdiagnostic parent training in child psychiatry empower parents to support their children's emotional regulation? A qualitative interview study of parents' and clinicians' perspectives on Circle of Security-Parenting (COS-P).

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology
Many children referred to child psychiatry show insecure attachment, indicating difficulties in the parent–child relationship. Attachment-based interventions aim to strengthen this relationship by enhancing parental sensitivity and under-standing of the ...
Møller Gitte Gaedt, Kring Lotte, Bikic Aida   +2 more
doaj   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Sibling relationships as a mediator and a moderator between parental attachment and depression among adolescents

BMC Psychology
Depression threatens adolescents’ psychological health and is influenced by negative interpersonal relationships. Previous studies have explored the effect of a negative parent−child relationship on adolescent depression but have ignored the frequent ...
Beibei Kuang, Yujing Zhao, Baojing Zhang, Jue Deng, Huahua Hu, Tong Ge   +5 more
doaj   +1 more source

Infant-mother attachment security, contextual risk, and early development: A moderational analysis [PDF]

, 2002
In light of evidence that the effects of attachment security on subsequent development may be contingent on the social context in which the child continues to develop, we examined the effect of attachment security at age 15 months, cumulative contextual ...
Fearon, RMP, Belsky, J
core  

A Breadth‐First Pruned‐Enriched Rosenbluth Method for Force–Extension Simulations of Confined Semiflexible Chains

Advanced Intelligent Discovery, EarlyView.
The behaviors of semiflexible polymers such as DNA and protein are often reshaped by coupled interactions. Monte Carlo simulations assist in studying these systems. This work recasts the traditional chain‐growth strategy into a new framework: a fixed number of chains grow synchronously, while less relevant chains to the target system are removed and ...
Yihan Zhao, Jizeng Wang
wiley   +1 more source