Results 51 to 60 of about 30,818 (233)

Optimization of Magnetic Milli‐Spinner for Robotic Endovascular Intervention

Advanced Robotics Research, EarlyView.
This work presents the design optimization of a multifunctional magnetic milli‐spinner for high‐speed propulsion and efficient clot debulking. The optimized design achieves an ultrafast swimming velocity of 55 cm/s (≈175 body lengths/s) in saline water, enabling stable upstream swimming against strong physiological flows and establishing magnetic milli‐
Lu Lu, Luca Higgins, Jack Bernardo, Ruike Renee Zhao   +3 more
wiley   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Holding a foster child’s mind in mind: study protocol for a cluster-randomized controlled trial of mentalization-based therapy (MBT) for foster families

BMC Psychology, 2023
Background Children in foster care are psychologically vulnerable and show more social, developmental, and behavioral problems than those living with their family of origin.
Nina Thorup Dalgaard, Anne Marie Anker Villumsen, Kresta Munkholt Sørensen, Nick Midgley, Mette Skovgaard Væver, Mathilde Almlund, Maiken Pontoppidan   +6 more
doaj   +1 more source

Effects of Adolescent Temperament and Parent-child Attachment on Depression

Journal of Korean Academy of Child Health Nursing, 2012
Purpose: This study was done to examine levels of temperament, parent-child attachment and depression of adolescents and verify its effects. Methods: Surveys were conducted with 500 students from two middle schools, one located in Seoul and one in Gyeonggi Province.
So-Youn Yim, Myoung-Ok Chae, Ja-Hyung Lee   +2 more
openaire   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

The specificity of mother's attachment to her child at an early age in the normal and severe dysontogenesis

Психология и Психотерапия Семьи, 2019
The study is focused on characteristics of attachment between a mother and her child of an early age. We have studied both families with typically developing children and families with children having signs of severe developmental disorders.
Tatiana Yakimova, PhD, Lyubov Metelkina
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

A Bibliometric Analysis of Publication Trends of Empirical Studies Over the Past 50 years Using the Child Attachment Studies Catalog and Data Exchange (CASCADE)

SAGE Open
This study describes the historical trends and gaps of attachment research through a bibliometric analysis of past research on observational measures of child-parent attachment.
Anh Ly, Audrey-Ann Deneault, Robbie Duschinsky, Carlo Schuengel, Sheri Madigan   +4 more
doaj   +1 more source

Exploring adverse parent-child relationships from the perspective of convicted child murderers: A South African qualitative study.

PLoS ONE, 2018
Child homicide is the most extreme form of violence against children. Within South Africa, children face the highest risk of homicide by parents/caregivers.
Bianca Dekel, Naeemah Abrahams, Michelle Andipatin   +2 more
doaj   +1 more source