Results 71 to 80 of about 238,336 (285)

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Holding a foster child’s mind in mind: study protocol for a cluster-randomized controlled trial of mentalization-based therapy (MBT) for foster families

BMC Psychology, 2023
Background Children in foster care are psychologically vulnerable and show more social, developmental, and behavioral problems than those living with their family of origin.
Nina Thorup Dalgaard, Anne Marie Anker Villumsen, Kresta Munkholt Sørensen, Nick Midgley, Mette Skovgaard Væver, Mathilde Almlund, Maiken Pontoppidan   +6 more
doaj   +1 more source

Attachment Theory and Maternal Drug Addiction: The Contribution to\ua0Parenting interventions. [PDF]

, 2016
Children\u2019s emotional and relational development can be negatively influenced bymaternal substance abuse, particularly through a dysfunctional caregiving environment.
Parolin, Micol, Simonelli, Alessandra
core   +2 more sources

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

The specificity of mother's attachment to her child at an early age in the normal and severe dysontogenesis

Психология и Психотерапия Семьи, 2019
The study is focused on characteristics of attachment between a mother and her child of an early age. We have studied both families with typically developing children and families with children having signs of severe developmental disorders.
Tatiana Yakimova, PhD, Lyubov Metelkina
doaj   +1 more source

Distracted Parenting: How Social Media Affects Parent-Child Attachment [PDF]

, 2016
Social media usage for parents has become ubiquitous, as either a form of entertainment or communication with other individuals. However, excessive use of social media has also shown to have effects on parenting; causing parental distraction, decreasing ...
Ante-Contreras, Denise
core  

Peran Parent Child Relationship Pada Orientasi Seksual Gay [PDF]

, 2017
This research is conducted to see the role of parent child relationship in gay. Parent child relationship is an interaction between parent and a child which is included three main aspects namely, parenting, attachment, and social learning ...
Retaminingrum, A. N. (Amalia)
core   +2 more sources

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

A Bibliometric Analysis of Publication Trends of Empirical Studies Over the Past 50 years Using the Child Attachment Studies Catalog and Data Exchange (CASCADE)

SAGE Open
This study describes the historical trends and gaps of attachment research through a bibliometric analysis of past research on observational measures of child-parent attachment.
Anh Ly, Audrey-Ann Deneault, Robbie Duschinsky, Carlo Schuengel, Sheri Madigan   +4 more
doaj   +1 more source