Results 81 to 90 of about 2,189,507 (275)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Exploring adverse parent-child relationships from the perspective of convicted child murderers: A South African qualitative study.

PLoS ONE, 2018
Child homicide is the most extreme form of violence against children. Within South Africa, children face the highest risk of homicide by parents/caregivers.
Bianca Dekel, Naeemah Abrahams, Michelle Andipatin   +2 more
doaj   +1 more source

The loss of a child: the long term impact upon the parent-child bond [PDF]

Research has been carried out from a psychological perspective, to examine the effects of bereavement in families when they have experienced the loss of a baby, child, teenager or young adult.
Merrington, Bill
core  

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

ADHD Symptoms in Middle Childhood: The Role of Child Attachment and Maternal Emotional Availability in an Inpatient Clinical Sample

European Journal of Investigation in Health, Psychology and Education
Background: Child ADHD symptoms are highly prevalent in middle childhood, alongside impairment in social functioning. The parent–child relationship has been shown to play an important role; however, studies investigating specific facets of the parent ...
Michaela Augustin, Volker Mall, Maria Licata-Dandel   +2 more
doaj   +1 more source

A Different Approach to Mother and Child Interaction: Theraplay Play Therapy [PDF]

Psikiyatride Güncel Yaklaşımlar
Theraplay is an interaction and attachment based play therapy model which aims to increase self-esteem and confidence. It is also an approach that aims to lead healthy parent and child relationships with secure attachment and improvement in current ...
Arzu Akar Gencer, Ayse Belgin Aksoy
doaj   +1 more source

Deep Learning Prediction of O‐Glycopeptide Tandem Mass Spectra Enhances O‐Glycoproteomics

Advanced Science, EarlyView.
DeepGPO integrates Transformer and graph neural networks with tailored training strategies, including data augmentation, loss re‐weighting, and pre‐training, to achieve high‐quality O‐glycopeptide MS/MS spectra prediction. The predicted MS/MS spectra are used to localize O‐glycosylation sites from HCD MS/MS data, enhancing O‐glycoproteomics analysis ...
Yu Zong, Yuxin Wang, Liang Qiao
wiley   +1 more source

When Mothers and Fathers Are ‘Gone’: Predicting Intergenerational Cycles of Risk in Opioid-Involved Parents

Children
Background/Objectives: The opioid epidemic and adverse childhood experiences (ACEs) are two major concerns for child welfare systems. Little is known, however, regarding the mechanisms that perpetuate intergenerational cycles of ACEs and insecure ...
Maria Khan, Kimberly Renk
doaj   +1 more source

Emotional Availability: Theory, Research, and Intervention

Frontiers in Psychology, 2015
Attachment Theory (Bowlby, 1969) and its limitations are first described. Next, emotional availability (EA; Biringen, Robinson, & Emde, 1998; Biringen, 2008) is introduced as an expansion upon the original conceptualization of the parent-child attachment
Hannah eSaunders, Allyson eKraus, Lavinia eBarone, Zeynep eBiringen   +3 more
doaj   +1 more source

The cornerstone of quality in family day care and child care centres – parent-professional partnerships [PDF]

, 2001
Introduction This booklet aims to present a \u27picture\u27 about parent-professional partnerships in a practical and relevant way that can support continuous improvement in family day care and centre based child care.
Anne Stonehouse
core