Results 51 to 60 of about 53,142 (303)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Difference and belonging, hopes and fears: parenting ‘mixed’ children and the implications for career development [PDF]

, 2008
Rosalind Edwards, Professor in Social Policy and Director of the Families & Social Capital Research Group, at London South Bank University, discusses parenting issues and their implications for career development at the CeGS 10th Annual Lecture held at ...
Edwards, R., Edwards, Rosalind
core  

Do Less Mindful Mothers Show Better Parenting via Improvements in Trait Mindfulness Following a Military Parent Training Program?

Frontiers in Psychology, 2019
Parental deployment to war poses risks to children's healthy adjustment. The After Deployment Adaptive Parenting Tools (ADAPT) program was developed for post-deployed military families to promote children's well-being through improving effective ...
Na Zhang, Jingchen Zhang, Abigail H. Gewirtz, Abigail H. Gewirtz   +3 more
doaj   +1 more source

Influence of different caregiving styles on fundamental movement skills among children

Frontiers in Public Health, 2023
PurposeThis study investigated the influence of parenting and grandparenting caregiving styles on fundamental motor skills (FMS) of preschool children.MethodA total of 1,326 preschool children (698 boys, 628 girls) aged 4–6 years were recruited from the ...
Jiahui Hu, Shudan Zhang, Shudan Zhang, Weibing Ye, Yuanye Zhu, Huiling Zhou, Lihua Lu, Qian Chen, Mallikarjuna Korivi   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Overcoming barriers to effective early parenting interventions for attention-deficit hyperactivity disorder (ADHD): parent and practitioner views [PDF]

, 2014
BackgroundThe importance of early intervention approaches for the treatment of attention-deficit hyperactivity disorder (ADHD) has been increasingly acknowledged.
Smith, Elizabeth, M. M. Knowles, M. Thompson, Knowles, M. M., Thompson, M., E. Smith, Koerting, J., Knowles, M.M., J. Koerting, E. J. Sonuga‐Barke, D. C. McCann, Sonuga-Barke, E.J., S. Latter, McCann, D.C., Mccann, D. C., Sonuga-barke, E. J., Latter, S., Smith, E.   +17 more
core   +1 more source

Parenting: A Skill or an Art?

Vidhyayana, 2020
Parenting has been alternately characterized as a set of teachable skills and as an inborn artful practice shaped by personality, culture and intuition. This paper reviews theoretical perspectives (e.g., parenting styles), empirical measures of parental competence, and intervention research to argue that parenting is best viewed as a hybrid phenomenon:
openaire   +1 more source

The Effect of Parents’ Literacy Skills and Children’s Preliteracy Skills on the Risk of Dyslexia [PDF]

Journal of Abnormal Child Psychology, 2014
The combination of investigating child and family characteristics sheds light on the constellation of risk factors that can ultimately lead to dyslexia. This family-risk study examines plausible preschool risk factors and their specificity. Participants (N = 196, 42 % girls) included familial risk (FR) children with and without dyslexia in Grade 3 and ...
van Bergen, E., de Jong, P.F., Maassen, B., van der Leij, A.   +3 more
openaire   +8 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Parenting behavior and the risk of becoming a victim and a bully/victim : a meta-analysis study [PDF]

, 2013
Objective: Being bullied has adverse effects on children's health. Children's family experiences and parenting behavior before entering school help shape their capacity to adapt and cope at school and have an impact on children's peer relationship ...
Samara, Muthanna, Lereya, Suzet, Wolke, Dieter, Lereya, Suzet Tanya   +3 more
core   +1 more source