Results 61 to 70 of about 45,473 (256)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Influence of Toxic Parenting on Social Anxiety and Social Skills of SMAN Batusangkar Students

Ta'dib
Toxic parenting is a type of parental behavior whose impact can destroy a child's life, both in individual and social contexts. The aim of this research is to determine the effect of toxic parenting on students' social anxiety and social skills.
Rafsel Tas'adi, Dasril Dasril, Fatih Hatil Yusra, Anindita Anindita, Irman Irman, Rina Yulitri, Wenda Asmita   +6 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Parenting pathways to friendship: how Self-Control and emotion management skills mediate preschoolers’ social lives in China?

BMC Psychology
Background Parenting styles have been identified as significant factors influencing children’s social behaviors, particularly in their peer interactions.
Dexian Li, Wencan Li, Xin Lin, Xingchen Zhu   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Parenting styles and externalizing problem behaviors of preschoolers: mediation through self-control abilities and emotional management skills

Frontiers in Psychology
IntroductionThe detection rate of externalizing problem behaviors among Chinese children has been increasing year by year. Before the age of six, the problem behaviors that appear in children are predominantly externalizing problem behaviors.
Zhang WenLi, Xu Tiemei, Li Shuangqi, Yu Qun, Zhu Jingbo, Sun Sijie   +5 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Islamic Counseling to Improve Quality of Parenting Pattern

Konseling Religi: Jurnal Bimbingan Konseling Islam, 2019
So many problems that occur in children and adolescents, one of which is the increased juvenile delinquency. One of the factors of the problem is the low quality of care or parenting.
Ahmad Saifuddin
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Child Support Compliance in Fatherhood Programs: The Role of Hope, Role Salience, and Parenting Skills

Journal of Human Sciences and Extension, 2019
Non-resident fathers’ compliance with child support agreements is low. An estimated 50% of fathers never pay any formal support to their co-parents (Stykes, Manning, & Brown, 2013). Responsible fatherhood programs have been developed as an alternative to
Alexander E. Chan, Francesca Adler-Baeder   +1 more
doaj   +1 more source