Results 61 to 70 of about 53,142 (303)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Clients or consumers, commonplace or pioneers? Navigating the contemporary class politics of family, parenting skills and education

, 2011
An explicit linking of the minutiae of everyday parenting practices and the good of society as a whole has been a feature of government policy. The state has taken responsibility for instilling the right parenting skills to deal with what is said to be ...
Edwards, Rosalind, Gillies, Val
core   +1 more source

Process evaluation of the Teamplay parenting intervention pilot : implications for recruitment, retention and course refinement [PDF]

, 2013
Background Parenting programs could provide effective routes to increasing children’s physical activity and reducing screen-viewing. Many studies have reported difficulties in recruiting and retaining families in group parenting interventions.
Bentley, Georgina F., Goodred, Joanna K., Sebire, Simon J, Turner, Katrina M., Jago, Russell, Sebire, Simon J., Fox, Kenneth R, Fox, Kenneth R., Stewart-Brown, Sarah, Bentley, Georgina F, Lucas, Patricia J., Lucas, Patricia J, Goodred, Joanna K, Stewart-Brown, Sarah L., Turner, Katrina M   +14 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PROGRAM PENGASUHAN POSITIF UNTUK MENINGKATKAN KETERAMPILAN MINDFUL PARENTING ORANGTUA REMAJA

Psympathic: Jurnal Ilmiah Psikologi, 2016
Deal with children in adolescence stage, parents often showing impatience behavior, unable to control him/herself, complaining when faced with difficulties in parenting and do not listen attentively toward child’s problems.
Pathah Pajar Mubarok
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Influence of Toxic Parenting on Social Anxiety and Social Skills of SMAN Batusangkar Students

Ta'dib
Toxic parenting is a type of parental behavior whose impact can destroy a child's life, both in individual and social contexts. The aim of this research is to determine the effect of toxic parenting on students' social anxiety and social skills.
Rafsel Tas'adi, Dasril Dasril, Fatih Hatil Yusra, Anindita Anindita, Irman Irman, Rina Yulitri, Wenda Asmita   +6 more
doaj   +1 more source

The Influence of Parents’ Parenting and Emotional Quotient on Students’ Social Skills

Tarbiya : Journal of Education in Muslim Society, 2017
This research aims at knowing and finding empirical data about the influence of independent variables, i.e., parenting and emotional quotient on students’ social skills as a dependent variable.This study employed a quantitative research design in the ...
Siti Masyithoh
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source