Results 81 to 90 of about 260,143 (289)

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A realist process evaluation of Enhanced Triple P for Baby and Mellow Bumps, within a Trial of Healthy Relationship Initiatives for the Very Early years (THRIVE): study protocol for a randomized controlled trial [PDF]

, 2019
Background: THRIVE is a three-arm randomised controlled trial (RCT) that aims to evaluate whether antenatal and early postnatal interventions, Enhanced Triple B for Baby (ETPB) plus care as usual (CAU) or Mellow Bumps (MB) plus CAU (versus CAU alone ...
Buston, Katie, Henderson , Marion, McGee, Elizabeth, O'Brien, Rosaleen, White, Jane, Wight , Danny   +5 more
core   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Program for Education and Enrichment of Relational Skills: Parental Outcomes with an ADHD Sample [PDF]

, 2016
The goal of the current study was to examine the effect of PEERS®, a 14-week parent-assisted friendship-building program for adolescents with ADHD, on parental functioning, quality of the parent-adolescent relationship, and family functioning ...
Gonring, Kelsey
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Responsive Parenting and Friendship Quality in Adolescents: Interpersonal Communication Skills as a Mediator

Bulletin of Counseling and Psychotherapy
Existing knowledge indicates that responsive parenting significantly influences the quality of friendships among adolescents. However, previous research has not fully elucidated the dynamics within the relationship between responsive parenting and ...
Aaliya Hana Mahirah, Marselius Sampe Tondok   +1 more
doaj   +1 more source

Predicting participation in group parenting education in an Australian sample: The role of attitudes, norms, and control factors [PDF]

, 2009
We examined the theory of planned behavior (TPB) in predicting intentions to participate in group parenting education. One hundred and seventy-six parents (138 mothers and 38 fathers) with a child under 12 years completed TPB items assessing attitude ...
AP Kaiser, C Armitage, C Armitage, C Smith, D Dinkmeyer, D Johnson, DJ Terry, DJ Terry, F Frankel, H Einzig, H Tajfel, HW Goddard, I Ajzen, I Ajzen, J Barlow, J Barlow, JC Turner, JE Dumas, K McCurdy, K McCurdy, Katherine M. White, KL Johnston, KM White, KM White, KP Haggerty, Larne Wellington, LJ Cronbach, M Conner, M Fishbein, MH Becker, MR Sanders, MR Sanders, MR Sanders, P Sparks, P Sparks, R Spoth, R Spoth, R Spoth, R Spoth, S Stryker, S Stryker, S Stryker, T Gordon, T Perrino   +43 more
core   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Development of a Causal Model of Social, Academic, and Emotional Risk-Taking based on Parenting Styles, Sensation-Seeking, Stress Coping Styles Mediated by Academic Skills in Students with High-Risk Behaviors

تحقیقات نظام سلامت, 2021
Background: The aim of this study was to develop a causal model of social, academic, and emotional risk-taking based on parenting styles, sensation-seeking, stress coping styles with mediation of academic skills in students with high-risk behaviors ...
Leila Amirian, Ezatolah Ghadampour, Mohammad Abasi   +2 more
doaj