Results 91 to 100 of about 261,891 (305)

Home and community based parenting support programmes and interventions: report of Workpackage 2 of the DataPrev project [PDF]

, 2010
The last decade has witnessed an increasing interest in the promotion of mental health and wellbeing because of its importance for health and social functioning at the individual level and for the social and economic wellbeing of societies.
McMillan, Anita Schrader, Stewart-Brown, Sarah L.   +1 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Pilot of ‘Families for Health’ : community-based family intervention for obesity [PDF]

, 2008
Objective - To develop and evaluate ‘Families for Health’ - a new community based family intervention for childhood obesity. Design – Programme development, pilot study and evaluation using intention-to-treat analysis.
Blissett, Jackie, Friede, Tim, Robertson, Wendy, Rudolf, Mary C. J., Stewart-Brown, Sarah L., Wallis, Maybelle   +5 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Responsive Parenting and Friendship Quality in Adolescents: Interpersonal Communication Skills as a Mediator

Bulletin of Counseling and Psychotherapy
Existing knowledge indicates that responsive parenting significantly influences the quality of friendships among adolescents. However, previous research has not fully elucidated the dynamics within the relationship between responsive parenting and ...
Aaliya Hana Mahirah, Marselius Sampe Tondok   +1 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Development of a Causal Model of Social, Academic, and Emotional Risk-Taking based on Parenting Styles, Sensation-Seeking, Stress Coping Styles Mediated by Academic Skills in Students with High-Risk Behaviors

تحقیقات نظام سلامت, 2021
Background: The aim of this study was to develop a causal model of social, academic, and emotional risk-taking based on parenting styles, sensation-seeking, stress coping styles with mediation of academic skills in students with high-risk behaviors ...
Leila Amirian, Ezatolah Ghadampour, Mohammad Abasi   +2 more
doaj  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Supporting Parenting [PDF]

, 2010
Governments are showing more and more interest in providing services to parents to help them fulfil their parenting roles. But what does "good" parenting mean? How can policies to support parents best be adapted to local culture?

core