Results 171 to 180 of about 12,704 (204)
Some of the next articles are maybe not open access.
Plant PARPs, PARGs and PARP-like Proteins
Current Protein & Peptide Science, 2016Poly(ADP-ribos)ylation, originally described as a mechanism of DNA break repair, is now considered as part of a complex regulatory system involved in dynamic reorganization of chromatin structure, transcriptional control of gene expression and regulation of metabolism. In plants poly(ADP-ribos)ylation has received surprisingly little attention.
Julia P, Vainonen +3 more
openaire +3 more sources
Purification of Recombinant Human PARG and Activity Assays
2022The purification of poly(ADP-ribose) glycohydrolase (PARG) from overexpressing bacteria Escherichia coli is described here as a fast and reproducible one chromatographic step protocol. After cell lysis, GST-PARG-fusion proteins from the crude extract are affinity purified by a glutathione 4B sepharose chromatographic step.
Amé, Jean-Christophe +1 more
openaire +3 more sources
TaqMan Multiplex qPCR Method to Genotype PARG Knockout Mice
2022Members of PARP family are responsible for poly(ADP-ribose) (pADPr) posttranslational modification synthesis. They are intensively studied proteins with more than 20,500 related papers in PubMed database search to date. PARG, the main enzyme that degrades pADPr, is unfairly attracted less attention, and 40 times less papers (a little more than 500) are
Yaroslava, Karpova, Alexei V, Tulin
openaire +2 more sources
A novel non-canonical PIP-box mediates PARG interaction with PCNA
Nucleic Acids Research, 2017 Poly(ADP-ribose) glycohydrolase (PARG) regulates cellular poly(ADP-ribose) (PAR) levels by rapidly cleaving glycosidic bonds between ADP-ribose units. PARG interacts with proliferating cell nuclear antigen (PCNA) and is strongly recruited to DNA damage sites in a PAR- and PCNA-dependent fashion.
Tanja Kaufmann +2 more
exaly +6 more sources
PARG inhibition induces nuclear aggregation of PARylated PARP1
StructurePoly (ADP-ribose) glycohydrolase (PARG) inhibitors are currently under clinical development for the treatment of DNA repair-deficient cancers; however, their precise mechanism of action is still unclear. Here, we report that PARG inhibition leads to excessive PARylated poly (ADP-ribose) polymerase 1 (PARP1) reducing the ability of PARP1 to properly ...
Sateja Paradkar +2 more
exaly +3 more sources
PARG inhibition induces nuclear aggregation of PARylated PARP1
2023AbstractPARG inhibitors are currently under clinical development for the treatment of DNA repair-deficient cancers, however, their precise mechanism of action is still unclear. Here we report that PARG inhibition causes increased nuclear PARylated PARP1 that limits PARP1 chromatin binding in response to DNA damage.
Sateja Paradkar +6 more
openaire +1 more source
PARP and PARG as novel therapeutic targets
Drugs of the Future, 2002Poly(ADP-ribose) is synthesized by poly(ADP-ribose) polymerase (PARP) from β-nicotinamide adenine dinucleotide (NAD + ). It is mainly degraded by poly(ADP-ribose) glycohydrolase (PARG). The expanding family of PARP currently consists of PARP 1 - 3 , vPARP, Tankyrase 1 - 2 , 2 , and more members are being characterized.
null Zhang, J., null Li, J.-H.
openaire +1 more source
Bacterial PARP/PARG enzymes – filogenetic and structural comparisson
2021ADP-ribosylation is an evolutionarily conserved reversible post-translational modification utilized from bacteria to humans. Bacteria were historically considered to be devoid of PAR metabolism, despite the fact many harbour genes homologous to the eukaryotic PARPs and PARGs.
Mikolčević, Petra +2 more
openaire +1 more source
2016
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions
Jordan, Allan +7 more
openaire +1 more source
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions
Jordan, Allan +7 more
openaire +1 more source
PARGE: parametric geocoding based on GCP-calibrated auxiliary data
SPIE Proceedings, 1998Nearly all current imaging spectroscopy data are obtained by scanning airborne systems. The stability of such systems is always worse than that of spaceborne platforms. Thus, geometric distortions occur due to variations of the flightpath as well as of the attitude of the plane. These distortions cannot be corrected simply by ground control point based
Daniel Schlaepfer +2 more
openaire +1 more source