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Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor. [PDF]
Marks D +11 more
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Paclitaxel-induced germline DNA-damage signatures independent of mismatch repair in <i>C. elegans</i>. [PDF]
Hong Y, Liu Z, Kim HM.
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Kinetics of Macroion Adsorption on Silica: Complementary Theoretical and Experimental Investigations for Poly-l-arginine. [PDF]
Morga M +6 more
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Discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence module against toxic attack. [PDF]
Lu Y +8 more
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Screening the Pandemic Response Box identifies novel ligands of the Staphylococcus aureus protein arginine kinase, McsB. [PDF]
Chetty R +4 more
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PARG Inhibitors and Functional PARG Inhibition Models
Current Protein & Peptide Science, 2016Poly(ADP-ribose) polymerases (PARPs) family proteins catalyze poly(ADP-ribosylation) (PARylation) by conjugating ADP-ribose residues repeatedly on amino acid residues using nicotinamide adenine dinucleotide as a substrate. The inhibitors of PARP widely block DNA repair processes and are currently examined in clinical trials of cancer therapy.
Yuka, Sasaki +6 more
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