Results 41 to 50 of about 3,203 (180)

New approach to paricalcitol synthesis [PDF]

Chinese Science Bulletin, 2012
Paricalcitol, an analog of vitamin D, is used as a drug for the prevention and treatment of secondary hyperparathyroidism. In this paper, a new strategy for the synthesis of paricalcitol is described. This approach includes three main improvements: one-pot regioselective ozonization cleavage of the side-chain and methylene at C-19, free-radical ...
Li, LiQi, Yue, LiRong, Xue, JiJun, Xie, ZhiXiang, Li, Ying   +4 more
openaire   +1 more source

The sequestration of the β-catenin transcriptional activity, via vitamin D receptor (VDR), after paricalcitol treatment.

, 2013
Coimmunoprecipitation reveals that paricalcitol induced VDR/β-catenin complex formation in HK-2 cells. The cells were pretreated with paricalcitol for 3 h, followed by 10 µM HHE treatment for 6 h. Pari, paricalcitol.
Joon Seok Choi (413565), Eun Hui Bae (413566), JongUn Lee (413569), Ko Eun Lee (413564), Chang Seong Kim (413562), Suhn Hee Kim (413568), Soo Yeon Joo (413563), Seong Kwon Ma (413567), Soo Wan Kim (413570)   +8 more
core   +1 more source

Paricalcitol attenuates indoxyl sulfate-induced apoptosis through the inhibition of MAPK, Akt, and NF-kB activation in HK-2 cells [PDF]

The Korean Journal of Internal Medicine, 2019
Background/Aims Indoxyl sulfate (IS) is a uremic toxin and an important causative factor in the progression of chronic kidney disease. Recently, paricalcitol (19-nor-1,25-dihydroxyvitamin D2) was shown to exhibit protective effects in kidney injury. Here,
Jung Sun Park, Hoon In Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim   +4 more
doaj   +1 more source

Efectos pleiotrópicos del paricalcitol, más allá del metabolismo óseo-mineral

Nefrología, 2016
El hiperparatiroidismo secundario (HPTS) es una complicación habitual en pacientes con enfermedad renal crónica que se caracteriza por unos niveles elevados de hormona paratiroidea (PTH) y una serie de anomalías en el metabolismo mineral-óseo.
Jesús Egido, Alberto Martínez-Castelao, Jordi Bover, Manuel Praga, José Vicente Torregrosa, Elvira Fernández-Giráldez, Carlos Solozábal   +6 more
doaj   +1 more source

Clinical uses of 1,25-dihydroxy-19-nor-vitamin D2 (Paricalcitol)

, 2014
The activation of vitamin D receptors (VDR) - (including activation by 25-hydroxyvitamin D) - seems to have not only mineral-metabolism beneficial effects but also important extra-skeletal actions.
M. M. Díaz Encarnación, M. Cozzolino, J. Ballarín, M. Furlano, J. Bover, I. Dasilva, M. J. Lloret   +6 more
core   +1 more source

Evaluation of the effect of vitamin D on sodium fluoride–induced toxicity in reproductive functions of male rabbits

National Journal of Physiology, Pharmacy and Pharmacology, 2016
Background: Fluorosis is an endemic problem in many countries of the world. Aims and Objectives: To see the effect of fluoride on the reproductive system and to see the role, if any, of vitamin D analog paricalcitol on it.
Basem H Elesawy, Abd Al Rahman N Alghamdy, Ahmad El-Askary, Magdi M Salih   +3 more
doaj   +1 more source

Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures

, 2016
Vitamin D has various systemic effects on bone metabolism, modulation of the immune system, stabilization of the cell membrane, oxidative stress, inflammation, apoptosis, and various other hormones.
Sur, Halil YAnlmaz, Erbas, Oytun, Uyanikgil, Yigit, Cetin, Emel Oeykue, Cavusoglu, Tuerker, Solmaz, Volkan, Cinar, Bilge Piri   +6 more
core   +1 more source

Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score

BMC Nephrology, 2018
Background Cardiovascular complications are common in kidney transplant patients and calcification propensity of blood, measured as T50, is associated with cardiovascular outcomes.
Amin Ussif, Hege Pihlstrøm, Andreas Pasch, Hallvard Holdaas, Anders Hartmann, Knut Smerud, Anders Åsberg   +6 more
doaj   +1 more source

Vitamin D and methylarginines in chronic kidney disease (CKD). [PDF]

PLoS ONE, 2017
BACKGROUND:Vitamin D associates with the plasma concentration of the endogenous inhibitor of the nitric oxide system asymmetric dimethyl arginine (ADMA) and cross-sectional studies in CKD patients treated with the vitamin D receptor activator ...
Claudia Torino, Patrizia Pizzini, Sebastiano Cutrupi, Rocco Tripepi, Giovanni Tripepi, Francesca Mallamaci, Carmine Zoccali   +6 more
doaj   +1 more source

Beneficial effects of paricalcitol on cardiac dysfunction and remodelling in a model of established heart failure [PDF]

, 2021
The synthetic vitamin D3 analogue paricalcitol acts as a selective activator of the vitamin D receptor (VDR). While there is evidence for cardioprotective effects of paricalcitol associated with the VDR pathway, less information is available about the ...
Prieto, Patricia, Ruiz Hurtado, Gema, Tamayo, María, Martín-Nunes, Laura, Val-Blasco, Almudena, Fernández-Velasco, María, G.M.-Piedras, José, Navarro-García, José Alberto, Lage Negro, Eduardo, Delgado, Carmen   +9 more
core   +1 more source