Results 91 to 100 of about 9,423,446 (404)

Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease

Nature Genetics, 2009
We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the ...
J. Simón-Sánchez, C. Schulte, J. Bras, J. Bras, Manu Sharma, J. R. Gibbs, J. R. Gibbs, Daniela Berg, C. Paisán-Ruiz, Peter Lichtner, S. Scholz, S. Scholz, Dena G. Hernandez, Dena G. Hernandez, R. Krüger, Monica Federoff, C. Klein, A. Goate, J. Perlmutter, Michael Bonin, Mike A. Nalls, T. Illig, C. Gieger, H. Houlden, Michael Steffens, M. S. Okun, B. Racette, M. Cookson, K. Foote, Hubert H. Fernandez, Bryan J Traynor, S. Schreiber, S. Arepalli, Ryan R. Zonozi, Katrina Gwinn, M. V. D. Brug, M. V. D. Brug, Grisel Lopez, S. Chanock, A. Schatzkin, Yikyung Park, A. Hollenbeck, Jianjun Gao, Xuemei Huang, Nicholas W. Wood, D. Lorenz, G. Deuschl, Honglei Chen, Olaf Riess, John Hardy, A. Singleton, T. Gasser   +51 more
semanticscholar   +1 more source

Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition. Methods Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment ...
Jade Hannan, Sarah Newman‐Norlund, Natalie Busby, Sarah C. Wilson, Roger Newman‐Norlund, Chris Rorden, Julius Fridriksson, Leonardo Bonilha, Nicholas Riccardi   +8 more
wiley   +1 more source

Computational analysis of the LRRK2 interactome. [PDF]

, 2015
LRRK2 was identified in 2004 as the causative protein product of the Parkinson's disease locus designated PARK8. In the decade since then, genetic studies have revealed at least 6 dominant mutations in LRRK2 linked to Parkinson's disease, alongside one ...
Denny, P, Lewis, PA, Lovering, RC, Manzoni, C   +3 more
core  

Emergence of nonmotor symptoms as the focus of research and treatment of Parkinson's disease: Introduction to the special section on nonmotor dysfunctions in Parkinson's disease [PDF]

, 2013
Parkinson's disease (PD) is traditionally characterized by the cardinal motor symptoms of tremor, rigidity, slowness of movement, and impairments of posture, gait, and balance.
Cronin-Golomb, Alice
core   +1 more source

Phenotyping Healthcare Use 2–3 Decades Before the First Multiple Sclerosis Demyelinating Event

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Phenotype hospital, physician, and emergency department (ED) visits by diagnoses and specialty up to 29 years pre‐multiple sclerosis (MS) onset versus a matched population without MS. Methods We identified people with MS (PwMS) using population‐based administrative data from Ontario, Canada (1991–2020).
Helen Tremlett, Karl Everett, Colleen J. Maxwell, Feng Zhu, Ayesha Asaf, Ping Li, Kyla A. McKay, Yinshan Zhao, Ruth Ann Marrie   +8 more
wiley   +1 more source

Lidocaine injections and neck corset wearing improve dropped head syndrome in Parkinson's disease and related disorders

Clinical Parkinsonism & Related Disorders, 2019
Background: Patients with Parkinson's disease and related disorders (PDRD) may exhibit dropped head syndrome (DHS), which does not yet have an effective treatment.
Yohei Mukai, Yoshihiko Furusawa, Yuko Morimoto, Yuka Hama, Tomoya Kawazoe, Yuji Saitoh, Takashi Sakamoto, Yuji Takahashi, Miho Murata   +8 more
doaj  

Intraputamenal Infusion of Exogenous Neurturin Protein Restores Motor and Dopaminergic Function in the Globus Pallidus of MPTP-Lesioned Rhesus Monkeys

Cell Transplantation, 2008
The neurorestorative effects of exogenous neurturin (NTN) delivered directly into the putamen via multiport catheters were studied in 10 MPTP-lesioned rhesus monkeys expressing stable parkinsonism.
R. Grondin Ph.D., Z. Zhang, Y. Ai, F. Ding, A. A. Walton, S. P. Surgener, G. A. Gerhardt, D. M. Gash   +7 more
doaj   +1 more source

Author response: Effects of orthostatic hypotension on cognition in Parkinson disease [PDF]

, 2017
OBJECTIVE: To investigate the relation between orthostatic hypotension (OH) and posture-mediated cognitive impairment in persons with Parkinson's disease (PD) without dementia.
Canova, Alexander O., Centi, Justin, Cronin-Golomb, Alice, Freeman, Roy, Gibbons, Christopher H., Neargarder, Sandy   +5 more
core   +1 more source

Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease.

New England Journal of Medicine, 1998
BACKGROUND In many patients with idiopathic Parkinson's disease, treatment with levodopa is complicated by fluctuations between an "off" period, when the medication is not working and the motor symptoms of parkinsonism are present, and an "on" period ...
P. Limousin, P. Krack, P. Pollak, A. Benazzouz, C. Ardouin, D. Hoffmann, A. Benabid   +6 more
semanticscholar   +1 more source

Genetic Diversity and Expanded Phenotypes in Dystonia: Insights From Large‐Scale Exome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most prevalent movement disorders, characterized by significant clinical and etiological heterogeneity. Despite considerable heritability (~25%), the etiology in most patients remains elusive. Moreover, understanding correlations between clinical manifestations and genetic variants has become increasingly ...
Mirja Thomsen, Fabian Ott, Sebastian Loens, Gamze Kilic‐Berkmen, Ai Huey Tan, Shen‐Yang Lim, Ebba Lohmann, Kaja M. Schröder, Lea Ipsen, Lena A. Nothacker, Linn Welzel, Alexandra S. Rudnik, Frauke Hinrichs, Thorsten Odorfer, Kirsten E. Zeuner, Friederike Schumann, Andrea A. Kühn, Simone Zittel, Marius Moeller, Robert Pfister, Christoph Kamm, Anthony E. Lang, Yi Wen Tay, Ana Luísa de Almeida Marcelino, Marie Vidailhet, Emmanuel Roze, Joel S. Perlmutter, Jeanne S. Feuerstein, Victor S. C. Fung, Florence Chang, Richard L. Barbano, Steven Bellows, Aparna A. Wagle Shukla, Alberto J. Espay, Mark S. LeDoux, Brian D. Berman, Stephen Reich, Andres Deik, Andre Franke, Michael Wittig, Sören Franzenburg, Jens Volkmann, Norbert Brüggemann, H. A. Jinnah, Tobias Bäumer, Christine Klein, Hauke Busch, Katja Lohmann   +47 more
wiley   +1 more source