Results 91 to 100 of about 240,114 (259)
Oscillation-specific nodal alterations in early to middle stages Parkinsons disease. [PDF]
, 2019 Background: Different oscillations of brain networks could carry different dimensions of brain integration. We aimed to investigate oscillation-specific nodal alterations in patients with Parkinsons disease (PD) across early stage to middle stage by ...
Gu, Quanquan +14 more
core
Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease
Advanced Therapeutics, EarlyView.An upconversion‐based wireless optogenetic strategy enables an all‐optical deep brain modulation solution for treating Parkinson's disease in rodent animals without using electronics or any tethered cables, providing experimental evidence supporting a therapeutic mechanism of STN‐DBS by disruption of anterograde signal transmission along the indirect ...
Wenchong Zhang +13 more
wiley +1 more source
Timetable of Gait Cycle Events in Parkinson's Disease. [PDF]
, 2017 The study used an algorithmic method to measure fluctuations in the timetable of gait cycle events in patients with Parkinson's disease (PD). Subjects with severe PD (n=10; age 63.6 ± 10.1 years; Hoehn & Yahr [H & Y] disability score 3 or 4), mild PD (n ...
Kiriyama, Takao, Ueno, Satoshi
core
Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice
Advanced Science, EarlyView.This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.
Xianyun Wang +16 more
wiley +1 more source
Advanced Science, EarlyView.Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu +12 more
wiley +1 more source
The epidemiology of Parkinson's disease
The LancetThe epidemiology of Parkinson's disease shows marked variations in time, geography, ethnicity, age, and sex. Internationally, prevalence has increased over and above demographic changes. There are several potential reasons for this increase, including the decline in other competing causes of death.
Ben-Shlomo, Yoav +5 more
openaire +6 more sources
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
The Value of Multidisciplinary Care in Parkinson\u27s Disease [PDF]
, 2003 Educational Objectives 1. To recognize the signs and symptoms of Parkinson\u27s disease (PD). 2. To identify key treatment and management strategies for PD. 3.
Baron, Mark, Hirsch, Miriam
core +1 more source
Advanced Science, EarlyView.Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei +15 more
wiley +1 more source