Results 111 to 120 of about 9,647,508 (315)

An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2

Neurobiology of Disease, 2019
Background: Mutations in LRRK2 are the most common cause of autosomal dominant Parkinson's disease, and the relevance of LRRK2 to the sporadic form of the disease is becoming ever more apparent.
Natalie Connor-Robson, Heather Booth, Jeffrey G. Martin, Benbo Gao, Kejie Li, Natalie Doig, Jane Vowles, Cathy Browne, Laura Klinger, Peter Juhasz, Christine Klein, Sally A. Cowley, Paul Bolam, Warren Hirst, Richard Wade-Martins   +14 more
doaj   +1 more source

Laserlight visual cueing device for freezing of gait in Parkinson's disease: a case study of the biomechanics involved [PDF]

, 2015
Background: Freezing of gait (FOG) is a serious gait disorder affecting up to two-thirds of people with Parkinson's disease (PD). Cueing has been explored as a method of generating motor execution using visual transverse lines on the floor.
B. Evans, C. J. Egerton, Fahn S, Gerstmann J, J. D. Richards, J. Janssen, P. McCandless, Richards J   +7 more
core   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Serum uric acid levels in older adults: Associations with clinical outcomes and implications for reference intervals in those aged 70 years and over

Arthritis Care &Research, Accepted Article.
Objectives Reports have linked both high and low serum uric acid (SUA) levels to adverse health outcomes. This study aimed to establish a reference interval for SUA in older adults and assessed its association with clinically relevant outcomes in relatively healthy, community‐dwelling individuals aged 70 and older.
Amanda J Rickard, Cammie Tran, Hans G Schneider, Flavia M Cicuttini, Anita E Wluka, Ego Seeman, Johannes T Neumann, Md Nazmul Karim, Zhen Zhou, Sultana Monira Hussain, David P Q Clark, Daniel Clayton‐Chubb, Andrew M Tonkin, Lawrence J Beilin, Robyn L Woods, John J McNeil   +15 more
wiley   +1 more source

Thalamic Deep Brain Stimulation for Orthostatic Tremor

Tremor and Other Hyperkinetic Movements, 2011
Background: Orthostatic tremor is an uncommon disorder manifest by high frequency, low amplitude leg tremor upon weight bearing. Treatment with oral tremor agents is inconsistent and usually not satisfactory.
Toby C. Yaltho, William G. Ondo
doaj   +1 more source

Meta‐analysis of Association between Newer Glucose‐Lowering Drugs and Risk of Parkinson's Disease [PDF]

, 2023
Huilin Tang, Ying Lü, Michael S. Okun, William T. Donahoo, Adolfo Ramirez‐Zamora, Fei Wang, Yu Huang, Wei‐Han Chen, Beth A Virnig, Jiang Bian, Jingchuan Guo   +10 more
openalex   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Palliative care and Parkinson's disease : meeting summary and recommendations for clinical research [PDF]

, 2017
Introduction: Palliative care is an approach to caring for patients and families affected by serious illnesses that focuses on the relief of suffering through the management of medical symptoms, psychosocial issues, advance care planning and spiritual ...
Bekelman, David, Carter, Julie, Carter, Julie H., Fox, Siobhán, Galifianakis, Nicholas, Galifianakis, Nicholas B., Johnson, Miriam, Johnson, Miriam J., Katz, Maya, Kluger, Benzi, Kluger, Benzi M., Kutner, Jean, Kutner, Jean S., Miyasaki, Janis, Richfield, Edward, Richfield, Edward W., Subramanian, Indu, Timmons, Suzanne   +17 more
core   +1 more source

Data mining analysis of professor Qiu Changlin's Chinese Medicinal therapy for Parkinson's disease [PDF]

, 2023
Shuang Wu, Han Wu, Xuhong Jiang, Hongchen Li, Jie Luo   +4 more
openalex   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source