Results 201 to 210 of about 295,503 (301)

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Distinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlap. [PDF]

EBioMedicine
Stinson SE, Shadrin AA, Rahman Z, Rødevand L, Broce IJ, Selbæk G, Stefansson H, Haavik J, Parker N, Koch E, Frei O, O'Connell KS, Smeland OB, Djurovic S, Dale AM, van der Meer D, Andreassen OA.   +16 more
europepmc   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Olfactory Dysfunction and/or RBD for Mapping Parkinson's Disease Subtypes? [PDF]

Eur J Neurol
Velucci V, Defazio G.
europepmc   +1 more source

Field‐Driven Activation of Solid‐State Devices in Open Circuits for Energy Harvesting and Wireless Sensing

Advanced Science, EarlyView.
Time‐varying electric fields can activate solid‐state devices such as LEDs and capacitors for energy harvesting and powering in open circuits. The response of solid‐state devices to time‐varying electric fields caused by vibrations can be utilised for smart sensing of human motions and object vibrations.
Renyun Zhang, Magnus Hummelgård, Henrik Andersson, Nicklas Blomquist, Jonas Örtegren, Hans‐Erik Nilsson, Zhong Lin Wang   +6 more
wiley   +1 more source

Parkinson's disease and reading performance. [PDF]

Ophthalmic Physiol Opt
Herrero-Gracia A, Hernández-Andrés R, Merino CV, Muedra CP, Ciuffreda KJ, Díez-Ajenjo MA.   +5 more
europepmc   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Clinician and patient perspectives on meaningful Parkinson's disease impacts for digital assessment. [PDF]

Front Neurol
Pearlmutter A, Ellis R, Peterschmitt MJ.
europepmc   +1 more source

A High‐Throughput Live Imaging Platform to Investigate Circuit‐Dependent Regulation of Circadian Rhythms in Brain Tissue

Advanced Science, EarlyView.
Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari, Natalie Ness, Julieta Acosta, Marco Brancaccio   +3 more
wiley   +1 more source