Results 231 to 240 of about 9,561,546 (382)

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

Advanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai, Zhiqiang Zhu, Zuojun Liu, Hanzeng Li, Shunqing Xu   +13 more
wiley   +1 more source

Pesticide Exposure and Parkinson's Disease: A Qualitative Study of Experiences in Ireland. [PDF]

Health Expect
Collins LM, Moore S, O'Shea E, White A, Sullivan AM.   +4 more
europepmc   +1 more source

Parkinson's disease in a Scottish city. [PDF]

, 1986
W.J. Mutch, I. Dingwall‐Fordyce, A. W. Downie, Jams Paterson, Sayan Roy   +4 more
openalex   +1 more source

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

Neuron, 2015
Alicia M. Pickrell, R. Youle
semanticscholar   +1 more source

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science, EarlyView.
Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley   +1 more source

Epidemiology of autonomic dysfunction in Parkinson's disease (Review). [PDF]

Med Int (Lond)
Rissardo JP, Gadelmawla AF, Khalil I, Abdulgadir A, Bhatti KS, Fornari Caprara AL.   +5 more
europepmc   +1 more source

Associated postural adjustments in Parkinson's disease. [PDF]

, 1986
Jeremy Dick, John C. Rothwell, Alfredo Berardelli, Philip D. Thompson, Maxime Gioux, R. Benecke, B. L. Day, C. D. Marsden   +7 more
openalex   +1 more source

Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

Neuron, 2004
C. Paisán-Ruiz, S. Jain, E. Evans, W. Gilks, J. Simón, M. V. D. Brug, A. L. Munain, Silvia Aparicio, Á. Gil, N. Khan, Janel O. Johnson, Javier Rúiz Martínez, D. Nicholl, Itxaso Martí Carrera, Amets Saénz Peňa, R. Silva, A. Lees, J. Martí‐Massó, J. Pérez-Tur, N. Wood, A. Singleton   +20 more
semanticscholar   +1 more source

HIFU‐Driven Targeted Pyroptosis Therapy in Basal‐Like Breast Cancer

Advanced Science, EarlyView.
This study presents a HIFU‐driven pyroptosis strategy for BLBC treatment. Combining HIFU with platelet‐membrane hybridized liposomes encapsulating mitoxantrone enhances tumor targeting and efficacy. The synergistic treatment modulates key epigenetic regulators and activates the pyroptotic pathway through ROS generation and inflammasome signaling ...
Xiaomin Su, Yang Wang, Xifeng Qin, Yaqiong Xiao, Boshu Ouyang, Lina Hu, Lin Kang, Ruizhe Xu, Ce Xu, Zanya Sun, Chenyu Sun, Huishu Guo, Zhiqing Pang, Shun Shen   +13 more
wiley   +1 more source

Identifying Druggable Inflammatory Proteins Causally Contributing to Parkinson's Disease. [PDF]

Brain Behav
Zhang Z, Cao H, Baranova A, Zhang F.
europepmc   +1 more source