Results 31 to 40 of about 9,561,546 (382)
Musculoskeletal Pain in Parkinson's Disease
Frontiers in Neurology, 2022 BackgroundMusculoskeletal pain is commonly experienced in patients with Parkinson's disease (PD). Few studies have investigated the clinical characteristics and risk factors associated with musculoskeletal pain.ObjectivesTo investigate the distribution ...
Jun Li +20 more
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Noradrenaline and Parkinson's Disease [PDF]
Frontiers in Systems Neuroscience, 2011 Parkinson's disease (PD) is characterized by the degeneration of dopamine (DA) neurons in the substantia nigra pars compacta, and motor symptoms including bradykinesia, rigidity, and tremor at rest. These symptoms are exhibited when striatal dopamine concentration has decreased by around 70%.
Claire eDelaville +3 more
openaire +5 more sources
Clinical Parkinsonism & Related Disorders, 2023 Dopamine agonists (DAs) have demonstrated efficacy for the treatment of Parkinson’s disease (PD) but are limited by adverse effects (AEs). DAs can vary considerably in their receptor subtype selectivity and affinity, chemical composition, receptor ...
Stuart H. Isaacson +4 more
doaj +1 more source
The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates [PDF]
, 1993 Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very ...
Burg, M. +7 more
core +1 more source
Regulation of vesicular trafficking by Parkinson's disease-associated genes
AIMS Molecular Science, 2015 The regulatory mechanisms that control intracellular vesicular trafficking play important roles in cellular function and viability. Neurons have specific vesicular trafficking systems for synaptic vesicle formation, release and recycling.
Tsuyoshi Inoshita, Yuzuru Imai
doaj +1 more source
Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]
, 2015 Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Abramov, AY +5 more
core +2 more sources
Severe Constipation in Parkinson's Disease and in Parkinsonisms: Prevalence and Affecting Factors
Frontiers in Neurology, 2019 Background: constipation is one of the most common and disabling non-motor symptoms of Parkinson Disease (PD) and Parkinsonisms (PS). Few studies evaluate the difference of prevalence between PD and PS and the cause leading to a severe constipation in ...
Giuseppe Frazzitta +4 more
doaj +1 more source
Frontiers in Neurology, 2021 Objective: In a prospective study, we investigated the association between physical activity and various motor, non-motor outcomes, and quality of life in early Parkinson's disease (PD) participants in the PD Longitudinal Singapore Study.Background ...
Samuel Yong-Ern Ng +25 more
doaj +1 more source
How do I sound to me? Perceived changes in communication in Parkinson's disease [PDF]
, 2007 Objective: To examine self and carer perceived changes in communication associated with Parkinson's disease and relate these to speech intelligibility, gender, age and other disease measures.
Bosworth H. +9 more
core +1 more source
Medicine, 2016 Parkinson's disease (PD) is a common neurodegenerative condition, affecting 2–3% of individuals >65 years of age. Although it is defined as a movement disorder, patients also experience a range of non-motor symptoms, reflecting pathology that is more widespread than originally thought in the peripheral and autonomic nervous system as well as the ...
Williams-Gray, CH, Worth, PF
openaire +2 more sources