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Advances in cell transplantation therapy and gene therapy in Parkinson's disease

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2022
The role of cell transplantation therapy and gene therapy in the treatment of Parkinson's disease (PD) has attracted more and more attention. It has developed from laboratory research tools to clinical products for patients.
XU Bao⁃lei, CHAN Piu
doaj   +1 more source

Methamphetamine and Parkinson's Disease [PDF]

open access: yesParkinson's Disease, 2013
Parkinson's disease (PD) is a neurodegenerative disorder predominantly affecting the elderly. The aetiology of the disease is not known, but age and environmental factors play an important role. Although more than a dozen gene mutations associated with familial forms of Parkinson's disease have been described, fewer than 10% of all cases can be ...
Rosario Moratalla   +6 more
openaire   +5 more sources

Abnormal temporal coupling of tactile perception and motor action in Parkinson's disease [PDF]

open access: yes, 2017
Evidence shows altered somatosensory temporal discrimination threshold (STDT) in Parkinson's disease in comparison to normal subjects. In healthy subjects, movement execution modulates STDT values through mechanisms of sensory gating.
Baione, Viola   +8 more
core   +1 more source

Musculoskeletal Pain in Parkinson's Disease

open access: yesFrontiers in Neurology, 2022
BackgroundMusculoskeletal pain is commonly experienced in patients with Parkinson's disease (PD). Few studies have investigated the clinical characteristics and risk factors associated with musculoskeletal pain.ObjectivesTo investigate the distribution ...
Jun Li   +20 more
doaj   +1 more source

Simulation Study and At Home Diagnostic Tool for Early Detection of Parkinsons Disease [PDF]

open access: yesarXiv, 2021
Hypomimia is a condition in the early stages of the progression of Parkinsons disease that limits the movement of facial muscles, restricting the accurate depiction of facial expressions. Also known as facial masking, this condition is an early symptom of Parkinson's disease, a neurodegenerative disorder that affects movement. To date, no specific test
arxiv  

Severe Constipation in Parkinson's Disease and in Parkinsonisms: Prevalence and Affecting Factors

open access: yesFrontiers in Neurology, 2019
Background: constipation is one of the most common and disabling non-motor symptoms of Parkinson Disease (PD) and Parkinsonisms (PS). Few studies evaluate the difference of prevalence between PD and PS and the cause leading to a severe constipation in ...
Giuseppe Frazzitta   +4 more
doaj   +1 more source

Parkinson's disease: autoimmunity and neuroinflammation [PDF]

open access: yes, 2016
Parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. The resulting dopamine deficiency in the basal ganglia leads to a movement disorder that is characterized by classical parkinsonian ...
CINIGLIO APPIANI, MARIO   +9 more
core   +1 more source

Analysis, Identification and Prediction of Parkinson Disease Sub-Types and Progression through Machine Learning [PDF]

open access: yes, 2023
This paper represents a groundbreaking advancement in Parkinson disease (PD) research by employing a novel machine learning framework to categorize PD into distinct subtypes and predict its progression. Utilizing a comprehensive dataset encompassing both clinical and neurological parameters, the research applies advanced supervised and unsupervised ...
arxiv   +1 more source

Primary skin fibroblasts as a model of Parkinson's disease [PDF]

open access: yes, 2012
Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease.
A Grunewald   +84 more
core   +1 more source

Regulation of vesicular trafficking by Parkinson's disease-associated genes

open access: yesAIMS Molecular Science, 2015
The regulatory mechanisms that control intracellular vesicular trafficking play important roles in cellular function and viability. Neurons have specific vesicular trafficking systems for synaptic vesicle formation, release and recycling.
Tsuyoshi Inoshita, Yuzuru Imai
doaj   +1 more source

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