Results 31 to 40 of about 290,866 (278)

Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring

Neurobiology of Disease, 2022
Background: Motor symptoms of Parkinson's disease (PD) are apparent after a high proportion of dopamine neurons in the substantia nigra have degenerated.
Amanda R. Burmeister, Juozas Gordevicius, Emmanuel N. Paul, Christina Houck, Sonia George, Martha L. Escobar Galvis, Qiong Sha, Patrik Brundin, J. Andrew Pospisilik, Karen Racicot, Lena Brundin   +10 more
doaj   +1 more source

Primary skin fibroblasts as a model of Parkinson's disease [PDF]

, 2012
Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease.
A Grunewald, A Grunewald, A Petit, A Rakovic, A Sajadi, A Sprenger, AL Fridman, AL Fridman, AW Michell, B Stefano Di, Blas Morales-Gordo, C Mytilineou, C Piccoli, CA Costa da, CM Clements, DP Narendra, DT Woodley, E Fernandez-Espejo, EM Valente, F Pan-Montojo, F Soldner, FR Wiedemann, G Tesco, Georg Auburger, GP Connolly, H Braak, H Jiang, H Mortiboys, Heinz Reichmann, HH Hoepken, HH Hoepken, HM Huang, HM Huang, IF Khan, IH Park, J Hoenicka, J Waak, Jessica Drost, JM Harper, K Bayreuther, K Gorner, K Isobe, K Winkler-Stuck, Katrin Marcus, KH Narsinh, L Gasparini, L Grandoso, LS Tain, M Garcia-Arencibia, M Ikemura, M Jendrach, M Klinkenberg, M Sun, M Varma, M Wernig, Marina Jendrach, MB Graeber, MC Maj, Michael Klinkenberg, N Exner, N Hirashima, O Rothfuss, P Hoyo del, P Rieske, R Djaldetti, R Musanti, S Geisler, S Gispert, S Kaneko, S Mai, SM Hussein, Suzana Gispert, T Amo, T Gasser, T Shishido, Ulrich Brandt, Vania Broccoli, WG Tatton, Wolfram S. Kunz, WY Lee, Y Miki, Y Ren, Y Ren, YC Kim, Z Jingzhong   +84 more
core   +1 more source

Lidocaine injections and neck corset wearing improve dropped head syndrome in Parkinson's disease and related disorders

Clinical Parkinsonism & Related Disorders, 2019
Background: Patients with Parkinson's disease and related disorders (PDRD) may exhibit dropped head syndrome (DHS), which does not yet have an effective treatment.
Yohei Mukai, Yoshihiko Furusawa, Yuko Morimoto, Yuka Hama, Tomoya Kawazoe, Yuji Saitoh, Takashi Sakamoto, Yuji Takahashi, Miho Murata   +8 more
doaj   +1 more source

Adiponectin Paradox in Alzheimer's Disease; Relevance to Amyloidogenic Evolvability?

Frontiers in Endocrinology, 2020
Adiponectin (APN) is a multi-functional adipokine which sensitizes the insulin signals, stimulates mitochondria biogenesis, and suppresses inflammation.
Masaaki Waragai, Gilbert Ho, Yoshiki Takamatsu, Ryoko Wada, Shuei Sugama, Takato Takenouchi, Eliezer Masliah, Makoto Hashimoto   +7 more
doaj   +1 more source

How do I sound to me? Perceived changes in communication in Parkinson's disease [PDF]

, 2007
Objective: To examine self and carer perceived changes in communication associated with Parkinson's disease and relate these to speech intelligibility, gender, age and other disease measures.
Bosworth H., David J. Burn, Diana Jones, Emma Noble, Kelly G., Liesl Allcock, Nick Miller, Osgood C., Walshe M., Yorkston K.   +9 more
core   +1 more source

Adhesion molecules as potential targets for neuroprotection in a rodent model of Parkinson's disease

Neurobiology of Disease, 2011
Cell adhesion molecules might play an important role in the inflammatory mechanisms associated with neurodegeneration. We have previously observed, in rats, that subcutaneous injection of complete Freund's adjuvant (CFA), a pro-inflammatory agent that ...
Marie-Therese Armentero, Giovanna Levandis, Eleonora Bazzini, Silvia Cerri, Cristina Ghezzi, Fabio Blandini   +5 more
doaj   +1 more source

Advances in cell transplantation therapy and gene therapy in Parkinson's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
The role of cell transplantation therapy and gene therapy in the treatment of Parkinson's disease (PD) has attracted more and more attention. It has developed from laboratory research tools to clinical products for patients.
XU Bao⁃lei, CHAN Piu
doaj   +1 more source

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease [PDF]

, 2011
We present the first application of the hypothesis-rich mathematical theory to genome-wide association data. The Hamza et al. late-onset sporadic Parkinson's disease genome-wide association study dataset was analyzed.
A Lerner, A Ruepp, AA Merchant, AM Glazer, B Bakir-Gungor, B Dass, C Wolff, CB Do, CH Hawkes, D Subramaniam, DAD Monte, DI Chasman, E Eskin, FL Moore, H-C Fung, HR Kim, J Simón-Sánchez, K Lai, K Roeder, K Roeder, K Roeder, K Sekimizu, K Tsuboi, L Lum, LA Hindorff, LM Bekris, M Bak, M Plaisant, M Saad, M-X Li, N Miao, O Bragina, P Mill, P Whitton, PA Beachy, PW Ingham, RE Lamont, S Purcell, SM Chambers, SY Tay, TA Manolio, TH Hamza, TL Edwards, TS Keshava Prasad, V Palma, VF Rafuse, W Satake, Y Katoh   +47 more
core   +3 more sources

Musculoskeletal Pain in Parkinson's Disease

Frontiers in Neurology, 2022
BackgroundMusculoskeletal pain is commonly experienced in patients with Parkinson's disease (PD). Few studies have investigated the clinical characteristics and risk factors associated with musculoskeletal pain.ObjectivesTo investigate the distribution ...
Jun Li, Jun Li, Ben-Fan Zhu, Zhu-Qin Gu, Zhu-Qin Gu, Hui Zhang, Hui Zhang, Shan-Shan Mei, Shan-Shan Mei, Shao-Zhen Ji, Shao-Zhen Ji, Shu-Ying Liu, Shu-Ying Liu, Chao Han, Chao Han, Huai-Zhen Chen, Piu Chan, Piu Chan, Piu Chan, Piu Chan, Piu Chan   +20 more
doaj   +1 more source

Dopamine agonists in Parkinson’s disease: Impact of D1-like or D2-like dopamine receptor subtype selectivity and avenues for future treatment

Clinical Parkinsonism & Related Disorders, 2023
Dopamine agonists (DAs) have demonstrated efficacy for the treatment of Parkinson’s disease (PD) but are limited by adverse effects (AEs). DAs can vary considerably in their receptor subtype selectivity and affinity, chemical composition, receptor ...
Stuart H. Isaacson, Robert A. Hauser, Rajesh Pahwa, David Gray, Sridhar Duvvuri   +4 more
doaj   +1 more source