Results 31 to 40 of about 353,918 (328)

Dopamine agonists in Parkinson’s disease: Impact of D1-like or D2-like dopamine receptor subtype selectivity and avenues for future treatment

Clinical Parkinsonism & Related Disorders, 2023
Dopamine agonists (DAs) have demonstrated efficacy for the treatment of Parkinson’s disease (PD) but are limited by adverse effects (AEs). DAs can vary considerably in their receptor subtype selectivity and affinity, chemical composition, receptor ...
Stuart H. Isaacson, Robert A. Hauser, Rajesh Pahwa, David Gray, Sridhar Duvvuri   +4 more
doaj   +1 more source

Regulation of vesicular trafficking by Parkinson's disease-associated genes

AIMS Molecular Science, 2015
The regulatory mechanisms that control intracellular vesicular trafficking play important roles in cellular function and viability. Neurons have specific vesicular trafficking systems for synaptic vesicle formation, release and recycling.
Tsuyoshi Inoshita, Yuzuru Imai
doaj   +1 more source

Treatment of dystonia and tics

Clinical Parkinsonism & Related Disorders, 2020
Treatment of dystonia and tics continues to evolve. In dystonia, while oral agents such as benzodiazepines, baclofen and anticholinergics remain in use, botulinum toxin (BoNT) continues to be regarded as the treatment of choice for focal and segmental ...
Steven Bellows, Joseph Jankovic
doaj   +1 more source

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program [PDF]

, 2017
Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's ...
Albin, Roger, Alcalay, Roy N., Babcock, Debra, Bowman, F. DuBois, Chen-Plotkin, Alice, David, Karen K., Dawson, Ted M., Dewey, Richard B., Jr., Foroud, Tatiana, German, Dwight, Gwinn, Katrina, Huang, Xuemei, Lungu, Codrin, Petyuk, Vlad, Potashkin, Judith A., Rosenthal, Liana S., Saunders-Pullman, Rachel, Scherzer, Clemens R., Sieber, Beth-Anne, St Hillaire-Clarke, Coryse, Sutherland, Margaret, Swanson-Fischer, Christine, Vaillancourt, David E., Walt, David R., West, Andrew B., Zhang, Jing   +25 more
core   +1 more source

Severe Constipation in Parkinson's Disease and in Parkinsonisms: Prevalence and Affecting Factors

Frontiers in Neurology, 2019
Background: constipation is one of the most common and disabling non-motor symptoms of Parkinson Disease (PD) and Parkinsonisms (PS). Few studies evaluate the difference of prevalence between PD and PS and the cause leading to a severe constipation in ...
Giuseppe Frazzitta, Davide Ferrazzoli, Annarita Folini, Grazia Palamara, Roberto Maestri   +4 more
doaj   +1 more source

Understanding health care needs among Veterans with Parkinson's disease: A survey study

Frontiers in Neurology, 2022
Among Veterans, it is estimated that 110,000 are living with Parkinson's disease (PD) in the United States. Whether or not Veterans living with PD are enrolled in the Veterans Health Administration (VHA), they may require special considerations when it ...
Megan Feeney, John Duda, Amie Hiller, Amie Hiller, Jay Phillips, Christiana Evers, Nicole Yarab, Veronica Todaro, Lydia Rader, Sheera Rosenfeld   +9 more
doaj   +1 more source

Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]

, 2015
Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Abramov, AY, Angelova, PR, Gandhi, S, Horrocks, MH, Klenerman, D, Shchepinov, MS   +5 more
core   +2 more sources

Physical Activity Improves Anxiety and Apathy in Early Parkinson's Disease: A Longitudinal Follow-Up Study

Frontiers in Neurology, 2021
Objective: In a prospective study, we investigated the association between physical activity and various motor, non-motor outcomes, and quality of life in early Parkinson's disease (PD) participants in the PD Longitudinal Singapore Study.Background ...
Samuel Yong-Ern Ng, Samuel Yong-Ern Ng, Nicole Shuang-Yu Chia, Nicole Shuang-Yu Chia, Mirza Masoom Abbas, Mirza Masoom Abbas, Ehsan Seyed Saffari, Xinyi Choi, Xinyi Choi, Dede Liana Heng, Dede Liana Heng, Zheyu Xu, Zheyu Xu, Zheyu Xu, Kay-Yaw Tay, Kay-Yaw Tay, Kay-Yaw Tay, Wing-Lok Au, Wing-Lok Au, Wing-Lok Au, Eng-King Tan, Eng-King Tan, Eng-King Tan, Louis Chew-Seng Tan, Louis Chew-Seng Tan, Louis Chew-Seng Tan   +25 more
doaj   +1 more source

The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates [PDF]

, 1993
Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very ...
Burg, M., Horowski, R., Kalveram, K. T., Lange, Klaus W., Löschmann, P. A., Riederer, Peter, Sofic, E., Wachtel, H.   +7 more
core   +1 more source

Mild Cognitive Impairment in Parkinson’s Disease: A Review of Current Concepts

Neurology Research International, 2013
Mild Cognitive Impairment in Parkinson’s Disease (PD-MCI) is common and may be associated with accelerated progression to dementia. Considering the importance of this emerging entity, new diagnostic criteria have recently been proposed. Early recognition
Natalie C. Palavra, Sharon L. Naismith, Simon J. G. Lewis   +2 more
doaj   +1 more source