Results 31 to 40 of about 9,647,508 (315)

Adhesion molecules as potential targets for neuroprotection in a rodent model of Parkinson's disease

Neurobiology of Disease, 2011
Cell adhesion molecules might play an important role in the inflammatory mechanisms associated with neurodegeneration. We have previously observed, in rats, that subcutaneous injection of complete Freund's adjuvant (CFA), a pro-inflammatory agent that ...
Marie-Therese Armentero, Giovanna Levandis, Eleonora Bazzini, Silvia Cerri, Cristina Ghezzi, Fabio Blandini   +5 more
doaj   +1 more source

Advances in cell transplantation therapy and gene therapy in Parkinson's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
The role of cell transplantation therapy and gene therapy in the treatment of Parkinson's disease (PD) has attracted more and more attention. It has developed from laboratory research tools to clinical products for patients.
XU Bao⁃lei, CHAN Piu
doaj   +1 more source

Musculoskeletal Pain in Parkinson's Disease

Frontiers in Neurology, 2022
BackgroundMusculoskeletal pain is commonly experienced in patients with Parkinson's disease (PD). Few studies have investigated the clinical characteristics and risk factors associated with musculoskeletal pain.ObjectivesTo investigate the distribution ...
Jun Li, Jun Li, Ben-Fan Zhu, Zhu-Qin Gu, Zhu-Qin Gu, Hui Zhang, Hui Zhang, Shan-Shan Mei, Shan-Shan Mei, Shao-Zhen Ji, Shao-Zhen Ji, Shu-Ying Liu, Shu-Ying Liu, Chao Han, Chao Han, Huai-Zhen Chen, Piu Chan, Piu Chan, Piu Chan, Piu Chan, Piu Chan   +20 more
doaj   +1 more source

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program [PDF]

, 2017
Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's ...
Albin, Roger, Alcalay, Roy N., Babcock, Debra, Bowman, F. DuBois, Chen-Plotkin, Alice, David, Karen K., Dawson, Ted M., Dewey, Richard B., Jr., Foroud, Tatiana, German, Dwight, Gwinn, Katrina, Huang, Xuemei, Lungu, Codrin, Petyuk, Vlad, Potashkin, Judith A., Rosenthal, Liana S., Saunders-Pullman, Rachel, Scherzer, Clemens R., Sieber, Beth-Anne, St Hillaire-Clarke, Coryse, Sutherland, Margaret, Swanson-Fischer, Christine, Vaillancourt, David E., Walt, David R., West, Andrew B., Zhang, Jing   +25 more
core   +1 more source

Dopamine agonists in Parkinson’s disease: Impact of D1-like or D2-like dopamine receptor subtype selectivity and avenues for future treatment

Clinical Parkinsonism & Related Disorders, 2023
Dopamine agonists (DAs) have demonstrated efficacy for the treatment of Parkinson’s disease (PD) but are limited by adverse effects (AEs). DAs can vary considerably in their receptor subtype selectivity and affinity, chemical composition, receptor ...
Stuart H. Isaacson, Robert A. Hauser, Rajesh Pahwa, David Gray, Sridhar Duvvuri   +4 more
doaj   +1 more source

The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates [PDF]

, 1993
Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very ...
Burg, M., Horowski, R., Kalveram, K. T., Lange, Klaus W., Löschmann, P. A., Riederer, Peter, Sofic, E., Wachtel, H.   +7 more
core   +1 more source

Regulation of vesicular trafficking by Parkinson's disease-associated genes

AIMS Molecular Science, 2015
The regulatory mechanisms that control intracellular vesicular trafficking play important roles in cellular function and viability. Neurons have specific vesicular trafficking systems for synaptic vesicle formation, release and recycling.
Tsuyoshi Inoshita, Yuzuru Imai
doaj   +1 more source

Everyday walking with Parkinson's disease: understanding personal challenges and strategies [PDF]

, 2008
PURPOSE: This qualitative study was designed to explore the personal experience of everyday walking with Parkinson's disease (PD), the challenges and the strategies employed to compensate for difficulties, to help contextualise the scientific knowledge ...
Birleson, Angela, Hetherington, Victoria, Jones, Diana, Kwakkel, Gert, Nieuwboer, Alice, Rochester, Lynn, van Wegen, Erwin, Willems, Anne-Marie   +7 more
core   +2 more sources

Severe Constipation in Parkinson's Disease and in Parkinsonisms: Prevalence and Affecting Factors

Frontiers in Neurology, 2019
Background: constipation is one of the most common and disabling non-motor symptoms of Parkinson Disease (PD) and Parkinsonisms (PS). Few studies evaluate the difference of prevalence between PD and PS and the cause leading to a severe constipation in ...
Giuseppe Frazzitta, Davide Ferrazzoli, Annarita Folini, Grazia Palamara, Roberto Maestri   +4 more
doaj   +1 more source

Understanding health care needs among Veterans with Parkinson's disease: A survey study

Frontiers in Neurology, 2022
Among Veterans, it is estimated that 110,000 are living with Parkinson's disease (PD) in the United States. Whether or not Veterans living with PD are enrolled in the Veterans Health Administration (VHA), they may require special considerations when it ...
Megan Feeney, John Duda, Amie Hiller, Amie Hiller, Jay Phillips, Christiana Evers, Nicole Yarab, Veronica Todaro, Lydia Rader, Sheera Rosenfeld   +9 more
doaj   +1 more source