Results 31 to 40 of about 196,808 (340)
Adiponectin Paradox in Alzheimer's Disease; Relevance to Amyloidogenic Evolvability?
Frontiers in Endocrinology, 2020 Adiponectin (APN) is a multi-functional adipokine which sensitizes the insulin signals, stimulates mitochondria biogenesis, and suppresses inflammation.
Masaaki Waragai +7 more
doaj +1 more source
Uncovering Essential Tremor Genetics: The Promise of Long-Read Sequencing
Frontiers in Neurology, 2022 Long-read sequencing (LRS) technologies have been recently introduced to overcome intrinsic limitations of widely-used next-generation sequencing (NGS) technologies, namely the sequencing limited to short-read fragments (150–300 base pairs).
Luca Marsili +4 more
doaj +1 more source
There Is No Parkinson Disease [PDF]
Archives of Neurology, 2008 The term Parkinson disease defines a specific clinical condition characterized by a typical history and characteristic signs. This review examines the historical evolution of the concept of Parkinson disease and how the misunderstanding of Parkinson disease may be hindering clinical research trials. It is proposed that this syndrome be called Parkinson
openaire +3 more sources
Neurobiology of Disease, 2021 Autophagic dysregulation and lysosomal impairment have been implicated in the pathogenesis of Parkinson's disease, partly due to the identification of mutations in multiple genes involved in these pathways such as GBA, SNCA, ATP13a2 (also known as PARK9),
Michaela E. Johnson +10 more
doaj
Analysis and Evaluation of Handwriting in Patients with Parkinson's Disease Using kinematic, Geometrical, and Non-linear Features [PDF]
Computer methods and programs in biomedicine, 173, 43-52 (2019), 2020 Background and objectives: Parkinson's disease is a neurological disorder that affects the motor system producing lack of coordination, resting tremor, and rigidity. Impairments in handwriting are among the main symptoms of the disease. Handwriting analysis can help in supporting the diagnosis and in monitoring the progress of the disease.
arxiv +1 more source
Frontiers in Neurology, 2019 In its early stages multiple system atrophy (MSA), a neurodegenerative movement disorder, can be difficult to differentiate from idiopathic Parkinson's disease (PD), and emphasis has been put on identifying premotor symptoms to allow for its early ...
Tobias Warnecke +9 more
doaj +1 more source
Understanding health care needs among Veterans with Parkinson's disease: A survey study
Frontiers in Neurology, 2022 Among Veterans, it is estimated that 110,000 are living with Parkinson's disease (PD) in the United States. Whether or not Veterans living with PD are enrolled in the Veterans Health Administration (VHA), they may require special considerations when it ...
Megan Feeney +9 more
doaj +1 more source
Rehabilitation and Parkinson’s Disease [PDF]
Parkinson's Disease, 2012 Early after the turn of the century, much excitement was generated by the reports of Tillerson et al. [1, 2] that exercise appeared to protect against neuronal degeneration in rodent models of toxin-induced parkinsonism. Such findings, coupled with epidemiologic suggestions that persons with a history of moderate to vigorous exercise may have a ...
Gammon M. Earhart +3 more
openaire +5 more sources
Visual exploration in Parkinson’s disease and Parkinson’s disease dementia [PDF]
Brain, 2013 Parkinson's disease, typically thought of as a movement disorder, is increasingly recognized as causing cognitive impairment and dementia. Eye movement abnormalities are also described, including impairment of rapid eye movements (saccades) and the fixations interspersed between them.
Michael P. Clarke +5 more
openaire +5 more sources
Mild Cognitive Impairment in Parkinson’s Disease: A Review of Current Concepts
Neurology Research International, 2013 Mild Cognitive Impairment in Parkinson’s Disease (PD-MCI) is common and may be associated with accelerated progression to dementia. Considering the importance of this emerging entity, new diagnostic criteria have recently been proposed. Early recognition
Natalie C. Palavra +2 more
doaj +1 more source