Results 111 to 120 of about 236,137 (343)
A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, finding that NfL demonstrates high prognostic value and distinct ...
Natalia E. Owen +8 more
wiley +1 more source
Computational Approaches for Disease Gene Identification [PDF]
arXiv, 2017 Identifying disease genes from human genome is an important and fundamental problem in biomedical research. Despite many publications of machine learning methods applied to discover new disease genes, it still remains a challenge because of the pleiotropy of genes, the limited number of confirmed disease genes among whole genome and the genetic ...
arxiv
Additional file 4: of Blood transcriptomics of drug-naĂŻve sporadic Parkinsonâ s disease patients
, 2015 Square of the Mahalanobis distance calculated for each sample from both control and pathological class models. (PDF 3122 kb)
Calligaris, Raffaella +17 more
openaire +1 more source
CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu +12 more
wiley +1 more source
Meta-analysis of Gene Expression in Neurodegenerative Diseases Reveals Patterns in GABA Synthesis and Heat Stress Pathways [PDF]
arXiv, 2019 Neurodegenerative diseases are characterized as the progressive loss of neural cells, e.g. neurons, glial cells. Ageing, monogenic variations, viral infections, and many other factors are determined and speculated as causes for them. While many individual genes, such as APP for Alzheimer disease and HTT for Huntington disease, and biological pathways ...
arxiv
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
, 2017 Topological properties of the hub genes obtained from the turquoise module. (DOCX 11Â kb)
Paulami Chatterjee +3 more
openaire +1 more source
Alpha Methyldopahydrazine as an Adjunct to Levodopa Therapy in Parkinson’s Disease [PDF]
, 1975 D. W. Paty +3 more
openalex +1 more source
The Case of a 67‐Year‐Old Man With Memory Difficulties and Altered Sleep
Annals of Clinical and Translational Neurology, EarlyView.
Wesley Peng, Borna Bonakdarpour
wiley +1 more source