Results 131 to 140 of about 263,626 (317)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease

Frontiers in Molecular Neuroscience, 2019
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders with a global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both the sporadic and familial forms of the disease.
Carroll Rutherford Fields, Nora Bengoa-Vergniory, Richard Wade-Martins   +2 more
doaj   +1 more source

Additional file 1: of Recent advances in rehabilitation for Parkinsonâ s Disease with Exergames: A Systematic Review

, 2019
Table S1. Overview of the selected RCTs and Pilot Studies (PDF 276 kb)
Garcia-Agundez, Augusto, Folkerts, Ann-Kristin, Konrad, Robert, Caserman, Polona, Tregel, Thomas, Goosses, Mareike, GĂśbel, Stefan, Kalbe, Elke   +7 more
openaire   +1 more source

Impairment of gradual muscle adjustment during wrist circumduction in Parkinson's disease [PDF]

, 2011
Purposeful movements are attained by gradually adjusted activity of opposite muscles, or synergists. This requires a motor system that adequately modulates initiation and inhibition of movement and selectively activates the appropriate muscles.
van der Hoeven Johannes H., Leenders Klaus L., Valsan, Gopal, de Jong, Bauke M.; id_orcid, Toxopeus Carolien M., Klaus L. Leenders, Carolien M. Toxopeus, Bauke M. de Jong, Natasha M. Maurits, Bernard A. Conway, Leenders, Klaus L., Gopal Valsan, Bernard A Conway, Johannes H van der Hoeven, Klaus L Leenders, Maurits, Natasha M.; id_orcid, de Jong, Bauke M., Conway Bernard A., Johannes H. van der Hoeven, Maurits, Natasha M., Conway, Bernard A., Carolien M Toxopeus, Natasha M Maurits, Maurits Natasha M., Toxopeus, Carolien M., Valsan Gopal, Bauke M de Jong, van der Hoeven, Johannes H., de Jong Bauke M.   +28 more
core   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Botulinum Toxin for the Treatment of Hand Tremor

Toxins, 2018
The aim of this study is to review our longitudinal experience with onabotulinumtoxinA (onaBoNT-A) injections for medically refractory hand tremor. We performed a retrospective review of our database of patients treated with onaBoNT-A for hand tremor ...
Nicki Niemann, Joseph Jankovic
doaj   +1 more source

Additional file 4: Table S2. of Guidelines for dementia or Parkinsonâ s disease with depression or anxiety: a systematic review

, 2016
Mean Domain Question Scores From AGREE II Evaluation. (DOCX 16 kb)
Goodarzi, Zahra, Mele, Bria, Selynne Guo, Hanson, Heather, Jette, Nathalie, Patten, Scott, Pringsheim, Tamara, Jayna Holroyd-Leduc   +7 more
openaire   +1 more source

Diagnosis and treatment of autonomic failure, pain and sleep disturbances in Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology [PDF]

Background and objective Non-motor symptoms frequently develop throughout the disease course of Parkinson’s disease (PD), and pose affected individuals at risk of complications, more rapid disease progression and poorer quality of life.
Becktepe, Jos, Sixel-Döring, Friederike, Krismer, Florian, Winkler, Christian, Woitalla, Dirk, Fanciulli, Alessandra, Bähr, Mathias, Höglinger, Günter, German Parkinson’s Guideline Group, Buhmann, Carsten, Jost, Wolfgang H., Trenkwalder, Claudia, Hermann, Wiebke   +12 more
core   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Angiotensin type 1 receptor activation promotes neuronal and glial alpha-synuclein aggregation and transmission

npj Parkinson's Disease
The brain renin-angiotensin system (RAS) has been related to dopaminergic degeneration, and high expression of the angiotensin II (AngII) type 1 receptor (AT1) gene is a marker of the most vulnerable neurons in humans.
Lucia Lage, Ana I. Rodriguez-Perez, Begoña Villar-Cheda, Jose L. Labandeira-Garcia, Antonio Dominguez-Meijide   +4 more
doaj   +1 more source