Results 111 to 120 of about 213,535 (253)

Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton, Carol Hermon, Sarah Floud, Gillian Reeves, Isobel Barnes   +4 more
wiley   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

Additional file 1: of Status of the Parkinsonâ s disease gene family expression in non-small-cell lung cancer

, 2015
Results of t -test for gender and histology.
Liu, Quan, Zheng, Hong, Deng, Xu, Zhou, Dong, Dai, Ji   +4 more
openaire   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Angiotensin type 1 receptor activation promotes neuronal and glial alpha-synuclein aggregation and transmission

npj Parkinson's Disease
The brain renin-angiotensin system (RAS) has been related to dopaminergic degeneration, and high expression of the angiotensin II (AngII) type 1 receptor (AT1) gene is a marker of the most vulnerable neurons in humans.
Lucia Lage, Ana I. Rodriguez-Perez, Begoña Villar-Cheda, Jose L. Labandeira-Garcia, Antonio Dominguez-Meijide   +4 more
doaj   +1 more source

Driving impairment in patients with movement disorders: examining the Baylor driving questionnaire by objective driving assessment

Clinical Parkinsonism & Related Disorders
Background: The development of a screening tool to identify driving impairment in patients with movement disorders is an unmet need. Objective: To validate Baylor Driving Questionnaire for Movement Disorders (BDQMD) by objective driving assessment (ODA).
Abhishek Lenka, Ruosha Li, Karim Makhoul, Alan Gonzalez, Rory D. Mahabir, Joseph Jankovic   +5 more
doaj   +1 more source

Additional file 2: of Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinsonâ s disease

, 2015
Supplementary online material. (DOCX 119 kb)
Tamburrino, Anna, Churchill, Madeline, Oi Wan, Colino-Sanguino, Yolanda, Ippolito, Rossana, Bergstrand, Sofie, Wolf, Daniel, Niculin Herz, Sconce, Michelle, BjĂśrklund, Anders, Meshul, Charles, Decressac, Mickael   +11 more
openaire   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Additional file 1: of Evaluation of rotigotine transdermal patch for the treatment of apathy and motor symptoms in Parkinsonâ s disease

, 2016
Institutional Review Boards or Independent Ethics Committees of participating sites in the PD0005 study. (PDF 220 kb)
Hauser, Robert, Jaroslaw Slawek, Barone, Paolo, Dohin, Elisabeth, Surmann, Erwin, Asgharnejad, Mahnaz, Bauer, Lars   +6 more
openaire   +1 more source

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source