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Additional file 10: of Blood transcriptomics of drug-naĂŻve sporadic Parkinsonâ s disease patients
, 2015 List of common genes between A9 DA neurons of the SN in the mouse and differentially expressed transcripts in the blood of PD patients according to SAM (a) and PUMA (b). (PDF 3122 kb)Calligaris, Raffaella, Banica, Mihaela, Roncaglia, Paola, Robotti, Elisa, Finaurini, Sara, Vlachouli, Christina, Antonutti, Lucia, Iorio, Francesco, Carissimo, Annamaria, Cattaruzza, Tatiana, Ceiner, Andrea, Lazarevic, Dejan, Cucca, Alberto, Pangher, Nicola, Marengo, Emilio, Bernardo, Diego Di, Pizzolato, Gilberto, Gustincich, Stefano +17 moreopenaire +1 more sourceParkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2024 Update [PDF]
Background: For the past five years, our annual reports have been tracking the clinical development of new drug-based therapies for the neurodegenerative condition of Parkinson’s disease (PD). These reviews have followed the progress both of “symptomatic Buff, S, Stott, SRW, Rafaloff, G, Fiske, B, Pilcicka, A, McFarthing, K, Pitzer, K, Wyse, RK, Fuest, R, Beissert, K, Navangul, A +10 morecore +1 more sourceDissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. [PDF]
, 2010 We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS.R. A. Barker, Z. Su, Spencer, C.C.A., Pearson, Justin P., McCarthy, Mark I, Wellcome Trust Case Control Consortium 2, Sawcer, SJ, Craddock, Nicholas John, Markus, Hugh S, Viswanathan, Ananth C., L. Peltonen, Potter, S, Rautanen, A, Gray, E, Hardy, J., Donnelly, P., Casas, J.-P., V. Plagnol, Deloukas, P, CORVIN, AIDEN PETER, Langford, C., Sawcer, Stephen J, Peltonen, L, Jankowski, J., Palmer, Colin N. A., E. Bramon, Edkins, Sarah, M. I. McCarthy, Peltonen, L., null null, G. Band, Craddock, Nicholas, Hudson, Gavin, Gray, E., Palmer, CN, Morrison, KE, Su, Zhan, Evans, Jonathan, Corvin, A, Viswanathan, A.C., A. C. Viswanathan, Morrison, Karen, Mathew, Christopher G.; id_orcid, Palmer, Colin NA, Spencer, C. C., Donnelly, P, Evans, J, Morrison, K.E.; id_orcid, Hunt, S., Palmer, C.N.A., Wood, Nicholas W., Craddock, N, Brown, Martin A., Hunt, S, H. Blackburn, A. Strange, D. Burn, J. Evans, Corvin, A., P. Donnelly, Gardner, M, Chinnery, Patrick F., Palmer, C. N., Burn, D, A. J. Lees, Bramon, E, Potter, Simon, Pirinen, Matti, Trembath, Richard C, Plagnol, V., Hardy, John, McCarthy, M. I., J. P. Pearson, Morris, H. R., C. Freeman, Edkins, S., Clarke, Carl E, Blackburn, Hannah, Morris, H.R., Clarke, Carl; id_orcid, Plagnol, V, Trembath, RC, Bhatia, Kailash, Langford, C, Gardner, M., S. Edkins, Viswanathan, A. C., Peltonen, Leena, Burn, D., R. C. Trembath, Sawcer, Stephen J., K. Bhatia, C. Langford, McCarthy, MI, Spencer, Chris CA, Spencer, Chris, Strange, Amy, C. C. A. Spencer, Bellenguez, C., J. Jankowski, Freeman, C., Brown, M. A., Spencer, Chris C.A., Bhatia, K., Langford, Cordelia, Wood, NW, Barker, R. A., Freeman, Colin, Chinnery, PF, Hunt, Sarah, Clarke, Carl E., C. E. Clarke, Markus, HS, Lees, A. J., Spencer, Chris C. A., P. F. Chinnery, Gray, Emma, Chinnery, P. F., Morris, Huw R., H. R. Morris, Paisan-Ruiz, C., Clarke, C.E., McCarthy, Mark I., Brown, MA, Blackburn, H., Wood, N.W., Clarke, CE, Gardner, Michelle, Plagnol, Vincent, S. Potter, A. Rautanen, Wood, N. W., Pearson, JP, Hardy, J, Evans, J., Morrison, K. E., Morrison, Karen E., Mathew, CG, Donnelly, Peter, C. Paisan-Ruiz, Chinnery, P.F., Pirinen, M., Lees, A.J., A. Corvin, Mathew, Christopher G, Su, Z., Edkins, S, Craddock, N., Brown, Martin A, Morris, Huw Rees, Trembath, Richard C., Wood, Nicholas W, Pirinen, M, Viswanathan, Ananth C, Clarke, C. E., Burn, David, Barker, Roger A, Strange, A., Blackwell, JM, Casas, J. P., C. G. Mathew, Williams, Nigel W, Paisan-Ruiz, C, Lees, AJ, P. Deloukas, N. W. Williams, C. Bellenguez, UK Parkinson's Disease Consortium, Deloukas, P., Mathew, C. G., G. Hudson, Su, Z, Plomin, R., Spencer, Chris C A, N. W. Wood, Plomin, R, S. Hunt, Morris, Huw R, Casas, Juan-Pablo, Barker, Roger A., Barker, Roger, Brown, Matthew A, Casas, JP, Barker, R.A., Rautanen, Anna, Bramon, Elvira, Plomin, Robert, Jankowski, Janusz, Band, G., McCarthy, M.I., Freeman, C, M. A. Brown, Bhatia, K, Brown, M. A, Sawcer, S.J., J. M. Blackwell, H. S. Markus, M. Gardner, Lees, Andrew J, Morris, HR, Band, Gavin, Strange, A, Brown, Matthew A., Markus, H.S., Blackburn, H, Paisan-Ruiz, Coro, Rautanen, A., Williams, Nigel W., Williams, N.W., Pearson, Justin P, C. N. A. Palmer, Blackwell, J. M., Deloukas, Panos, Bellenguez, Celine, Williams, N. W., Morrison, K.E., S. J. Sawcer, Brown, M.A., Bramon, E., Trembath, R. C., Barker, RA, Spencer, CC, Blackwell, Jennie M, Chinnery, Patrick F, Blackwell, Jennie M., Hudson, G, Spencer, C. C. A., Markus, Hugh S., N. Craddock, Morrison, Karen E, Lees, Andrew J., Band, G, Palmer, Colin N A; id_orcid, Jankowski, J, Blackwell, J.M., K. E. Morrison, Hudson, G., E. Gray, Viswanathan, AC, Potter, S., Palmer, C. N. A., Mathew, C.G., Williams, NW, J.-P. Casas, Bellenguez, C, J. Hardy, Williams, Nigel Melville, Pearson, J.P., R. Plomin, Pearson, J. P., Corvin, Aiden, Sawcer, S. J., M. Pirinen, Trembath, R.C., Markus, H. S. +254 morecore +1 more sourceValidity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods
A comparative analysis between digital insoles Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe +16 morewiley +1 more sourceAdditional file 2: of Blood transcriptomics of drug-naĂŻve sporadic Parkinsonâ s disease patients
, 2015 Score plots of the first 6 PCs calculated on the dataset constituted by the 395 variables selected by Ranking-PCA. Control samples are represented as filled circles while pathological samples as void circles. Of the original 60 samples, one (a control sample) did not pass the microarray hybridization quality controls and was excluded from further ...Calligaris, Raffaella, Banica, Mihaela, Roncaglia, Paola, Robotti, Elisa, Finaurini, Sara, Vlachouli, Christina, Antonutti, Lucia, Iorio, Francesco, Carissimo, Annamaria, Cattaruzza, Tatiana, Ceiner, Andrea, Lazarevic, Dejan, Cucca, Alberto, Pangher, Nicola, Marengo, Emilio, Bernardo, Diego di, Pizzolato, Gilberto, Gustincich, Stefano +17 moreopenaire +1 more sourceHow do I sound to me? Perceived changes in communication in Parkinson's disease
, 2008 Objective: To examine self and carer perceived changes in communication associated with Parkinson's disease and relate these to speech intelligibility, gender, age and other disease measures.Miller, Nick, Jones, Diana, Emma Noble, Liesl Allcock, David J. Burn, Diana Jones, Burn, David, Noble, Emma, Allcock, Liesl, Nick Miller +9 morecore +1 more sourceBaseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin +6 morewiley +1 more sourceOnline cognitive monitoring technology for people with Parkinson’s disease and REM sleep behavioural disorder
npj Digital MedicineAutomated online cognitive assessments are set to revolutionise clinical research and healthcare. However, their applicability for Parkinson’s Disease (PD) and REM Sleep Behavioural Disorder (RBD), a strong PD precursor, is underexplored.Maria Bălăeţ, Falah Alhajraf, Tanja Zerenner, Jessica Welch, Jamil Razzaque, Christine Lo, Valentina Giunchiglia, William Trender, Annalaura Lerede, Peter J. Hellyer, Sanjay G. Manohar, Paresh Malhotra, Michele Hu, Adam Hampshire +13 moredoaj +1 more sourceThe Parkinson’s Disease Mendelian Randomization Research Portal [PDF]
, 2019 BackgroundMendelian randomization is a method for exploring observational associations to find evidence of causality. ObjectiveTo apply Mendelian randomization between risk factors/phenotypic traits (exposures) and Parkinson’s disease in a large ...McCreight, JC, Raquel Duran, Demis Kia, Hemani, G, Cornelis Blauwendraat, Hicks, B, Cuzick, J, Noyce, Alastair J., Hicks, Barry, Andrew B. Singleton, Kia, Demis A., Angli Xue, Hardy, J, Yang, J, Singleton, Andrew B., Kia, Demis, Heilbron, Karl, Nalls, Mike A, Kia, D, Jiang, Y, McManus, KF, Bryc, K, Gibran Hemani, Nalls, Mike A., Smith, George Davey, Hinds, David A., Gibbs, JR, Kim, Jonggeol, Visscher, Peter, Mike A. Nalls, Hinds, DA, Huw Morris, Blauwendraat, C, McIntyre, MH, Wood, Nicholas W, Cuzick, Jack, Fontanillas, P, Sara Bandres‐Ciga, Hinds, David A, Hemani, Gibran, Nalls, MA, Auton, Adam, Lawlor, Debbie A, Tung, JY, Davey Smith, George, Noyce, AJ, Bryc, Katarzyna, Jonggeol Kim, Alipanahi, B, Jewett, EM, Wang, X, Bell, RK, Northover, CAM, Wood, Nicholas W., Blauwendraat, Cornelis, Pitts, SJ, Visscher, P, Bandres-Ciga, S, Sathirapongsasuti, JF, Elson, Sarah L., Noyce, Alastair J, Ziv Gan‐Or, Smith, GD, Xue, Angli, Wilson, CH, Hardy, John, Furlotte, NA, Karl Heilbron, John Hardy, Nicholas W. Wood, Gan-Or, Ziv, Debbie A. Lawlor, Helibron, Karl, Heilbron, K, Litterman, NK, Bandres-Ciga, Sara, Visscher, Peter M, Peter Visscher, Xue, A, ?, ?, Kim, J, Lawlor, DA, IPDGC, Jian Yang, Yang, Jian, Alastair J. Noyce, Gan-Or, Z, Brandes Ciga, Sara, Singleton, AB, Morris, Huw, Noblin, ES, Agee, M, Mountain, JL, Poznik, GD, Bell, Robert K., Auton, A, Noyce, Alastair, Duran, R, Tian, C, Xue, Angil, Singleton, Andrew B, Elson, SL, Kleinman, A, Wood, NW, Vacic, V, Gibbs, J. Raphael, Duran, Raquel, Gibbs, J Raphael, Agee, Michelle, Shringarpure, S, J. Raphael Gibbs, Jack Cuzick, Alipanahi, Babak, Morris, H, Lawlor, Debbie A., Furlotte, Nicholas A., Huber, KE, Wood, Nicholas, Team, AR, Durán Ogalla, Raquel, George Davey Smith, Lin, K-H, Fontanillas, Pierre, Shelton, JF, David A. Hinds +124 morecore +1 more source
