Results 81 to 90 of about 263,626 (317)

Additional file 3: of Blood transcriptomics of drug-naĂŻve sporadic Parkinsonâ s disease patients

, 2015
List of the 395 variables selected by Ranking-PCA to discriminate between PD patients and controls. Order of variables, Affymetrix Probe Set IDs, gene symbols and names are indicated. (PDF 3122 kb)
Calligaris, Raffaella, Banica, Mihaela, Roncaglia, Paola, Robotti, Elisa, Finaurini, Sara, Vlachouli, Christina, Antonutti, Lucia, Iorio, Francesco, Carissimo, Annamaria, Cattaruzza, Tatiana, Ceiner, Andrea, Lazarevic, Dejan, Cucca, Alberto, Pangher, Nicola, Marengo, Emilio, Bernardo, Diego Di, Pizzolato, Gilberto, Gustincich, Stefano   +17 more
openaire   +1 more source

Mitochondria and quality control defects in a mouse model of Gaucher Disease-links to Parkinson's Disease [PDF]

, 2013
Mutations in the glucocerebrosidase (gba) gene cause Gaucher disease (GD), the most common lysosomal storage disorder, and increase susceptibility to Parkinson's disease (PD).
Duchen, Michael R., Gegg, ME, Osellame, LD, Gegg, Matthew E., Osellame, Laura D., Richard-Londt, A, Hargreaves, Iain P., Brandner, Sebastian, Brandner, S, Richard-Londt, Angela, Waddington, Simon N., Hargreaves, IP, Waddington, SN, Schapira, AHV, Rahim, AA, Rahim, Ahad A., Duchen, MR, Schapira, AH, Schapira, Anthony H.V.   +18 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

The emerging role and therapeutic targeting of autophagy-lysosome pathway in the pathogenesis of Parkinson’s disease

Translational Neurodegeneration
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss and the accumulation of misfolded α-synuclein, yet the underlying mechanisms remain incompletely understood. Over the past two decades, genetic
Takahiro Shimizu, Sanem Isik, Nitika Kamath, Zhenyu Yue   +3 more
doaj   +1 more source

Asymmetric Dopaminergic Degeneration and Attentional Resources in Parkinson’s Disease

Frontiers in Neuroscience, 2018
Background: Attention is crucial to voluntary perform actions in Parkinson’s disease (PD), allowing patients to bypass the impaired habitual motor control.
Paola Ortelli, Davide Ferrazzoli, Marianna Zarucchi, Roberto Maestri, Giuseppe Frazzitta   +4 more
doaj   +1 more source

Repetitive transcranial magnetic stimulation as a treatment for articulatory dysfunction in Parkinson’s disease [PDF]

, 2011
Neuroimaging has demonstrated that improved speech outcomes in Parkinson’s disease (PD) subsequent to behavioral treatment approaches is associated with increased activity in the motor and pre-motor cortex. High frequency repetitive transcranial magnetic
Barwood, CHS, Ng, ML, Murdoch, BE
core  

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Integrating technology into a successful apomorphine delivery program in Thailand: a 10-year journey of achievements with a five-motto concept

Frontiers in Neurology
IntroductionApomorphine, a potent dopamine agonist, is a therapeutic option for patients with Parkinson’s disease and motor fluctuations. However, the adoption of and adherence to this therapy have been limited by the need for complex delivery devices ...
Onanong Phokaewvarangkul, Nithinan Kantachadvanich, Vijittra Buranasrikul, Kanyawat Sanyawut, Saisamorn Phumphid, Chanawat Anan, Roongroj Bhidayasiri, Roongroj Bhidayasiri   +7 more
doaj   +1 more source

Additional file 6: of Blood transcriptomics of drug-naĂŻve sporadic Parkinsonâ s disease patients

, 2015
List of differentially expressed genes between PD patients and controls based on PUMA. Ratios are calculated as differences in gene expression between samples of PD patients and controls, with the top up-regulated genes first. (PDF 3122 kb)
Calligaris, Raffaella, Banica, Mihaela, Roncaglia, Paola, Robotti, Elisa, Finaurini, Sara, Vlachouli, Christina, Antonutti, Lucia, Iorio, Francesco, Carissimo, Annamaria, Cattaruzza, Tatiana, Ceiner, Andrea, Lazarevic, Dejan, Cucca, Alberto, Pangher, Nicola, Marengo, Emilio, Bernardo, Diego di, Pizzolato, Gilberto, Gustincich, Stefano   +17 more
openaire   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source