Results 61 to 70 of about 263,626 (317)

Live Imaging of Axonal Transport in the Motor Neurons of Drosophila Larvae

Bio-Protocol, 2017
Axonal transport, which is composed of microtubules, motor proteins and a variety of types of cargo, is a prominent feature of neurons. Monitoring these molecular dynamics is important to understand the biological processes of neurons as well as ...
Tsuyoshi Inoshita, Nobutaka Hattori, Yuzuru Imai   +2 more
doaj   +1 more source

MOESM3 of Prevalence and incidence of Parkinsonâ s disease and drug-induced parkinsonism in Korea

, 2019
Additional file 3: Figure S2. Sensitivity analysis. Number of incident patients with drug-induced parkinsonism by the types and numbers of offending drugs in ...
Han, Sola, Kim, Siin, Kim, Hyungtae, Shin, Hae-Won, Na, Kyoung-Sae, Suh, Hae Sun   +5 more
openaire   +1 more source

Cardiac parasympathetic dysfunction in the early phase of Parkinson’s disease [PDF]

, 2017
Cardiac parasympathetic function is strongly affected by aging. Although sympathetic dysfunction has been well documented in Parkinson’s disease (PD), cardiac parasympathetic dysfunction has not been well studied.
Nakamura, Tomohiko, Hirayama, Masaaki, Katsuno, Masahisa, Suzuki, Masashi, Ueda, Miki, Sobue, Gen   +5 more
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities

Translational Neurodegeneration, 2019
The fundamental role that alpha-synuclein (aSyn) plays in the pathogenesis of neurodegenerative synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, is a well-accepted fact.
Naomi P. Visanji, Anthony E. Lang, Gabor G. Kovacs   +2 more
doaj   +1 more source

Additional file 2: of LRRK2 contributes to monocyte dysregulation in Parkinsonâ s disease

, 2019
LRRK2 protein expression is significantly upregulated in monocytes from PD patients. (PDF 303 kb)
Bliederhaeuser, Corinna, Zondler, Lisa, Grozdanov, Veselin, Ruf, Wolfgang, Brenner, David, Melrose, Heather, Bauer, Peter, Ludolph, Albert, Gillardon, Frank, Kassubek, Jan, Weishaupt, Jochen, Danzer, Karin   +11 more
openaire   +1 more source

Pros and cons of a prion-like pathogenesis in Parkinson's disease [PDF]

, 2011
Background: Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder which affects widespread areas of the brainstem, basal ganglia and cerebral cortex.
Chapman Joab, Hilker, Ruediger, Brotchie, Jonathan M, Hilker, Rüdiger, Hilker Ruediger, Brotchie, Jonathan M., Joab Chapman, Ruediger Hilker, Chapman, Joab, Jonathan M Brotchie, Brotchie Jonathan M   +10 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Effect of dopamine on limbic network connectivity at rest in Parkinson’s disease patients with freezing of gait

Translational Neuroscience
Freezing of gait (FOG) in Parkinson’s disease (PD) has a poorly understood pathophysiology, which hinders treatment development. Recent work showed a dysfunctional fronto-striato-limbic circuitry at rest in PD freezers compared to non-freezers in the ...
Quek Dione Y. L., Taylor Natasha, Gilat Moran, Lewis Simon J. G., Ehgoetz Martens Kaylena A.   +4 more
doaj   +1 more source

TIA1 Mutant Mouse Model Exhibits Motor Deficits and Neurodegenerative Characteristics of Amyotrophic Lateral Sclerosis

Cells
Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that primarily affects the motor neurons. T cell intracellular antigen 1 (TIA1) is a risk gene for ALS pathogenesis. To elucidate TIA1-mediated disease mechanisms,
Li-Hong Mao, Yu-Ning Song, Jing-Qi Zhang, Yun-Ting Shao, Zhang-Li Wang, Na Yang, Wen-Xuan Zhang, Ying-Rui Zhang, Xiao-Yan Gao, Jia-Yi Li, Lin Yuan   +10 more
doaj   +1 more source