Results 61 to 70 of about 213,535 (253)
npj Parkinson's DiseaseDeep brain stimulation (DBS) is an effective treatment for patients with Parkinson’s disease (PD). However, some patients may not respond optimally to clinical programming adjustments.
Viviana Torres +8 more
doaj +1 more source
Live Imaging of Axonal Transport in the Motor Neurons of Drosophila Larvae
Bio-Protocol, 2017 Axonal transport, which is composed of microtubules, motor proteins and a variety of types of cargo, is a prominent feature of neurons. Monitoring these molecular dynamics is important to understand the biological processes of neurons as well as ...
Tsuyoshi Inoshita +2 more
doaj +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Additional file 6: of Blood transcriptomics of drug-naĂŻve sporadic Parkinsonâ s disease patients
, 2015 List of differentially expressed genes between PD patients and controls based on PUMA. Ratios are calculated as differences in gene expression between samples of PD patients and controls, with the top up-regulated genes first. (PDF 3122 kb)
Calligaris, Raffaella +17 more
openaire +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Translational NeuroscienceFreezing of gait (FOG) in Parkinson’s disease (PD) has a poorly understood pathophysiology, which hinders treatment development. Recent work showed a dysfunctional fronto-striato-limbic circuitry at rest in PD freezers compared to non-freezers in the ...
Quek Dione Y. L. +4 more
doaj +1 more source
Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities
Translational Neurodegeneration, 2019 The fundamental role that alpha-synuclein (aSyn) plays in the pathogenesis of neurodegenerative synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, is a well-accepted fact.
Naomi P. Visanji +2 more
doaj +1 more source
Additional file 10: of Blood transcriptomics of drug-naĂŻve sporadic Parkinsonâ s disease patients
, 2015 List of common genes between A9 DA neurons of the SN in the mouse and differentially expressed transcripts in the blood of PD patients according to SAM (a) and PUMA (b). (PDF 3122 kb)
Calligaris, Raffaella +17 more
openaire +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
CellsBackground: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that primarily affects the motor neurons. T cell intracellular antigen 1 (TIA1) is a risk gene for ALS pathogenesis. To elucidate TIA1-mediated disease mechanisms,
Li-Hong Mao +10 more
doaj +1 more source