Results 41 to 50 of about 457,449 (311)
Spatial judgment in Parkinson's disease: Contributions of attentional and executive dysfunction [PDF]
, 2019 Spatial judgment is impaired in Parkinson's disease (PD), with previous research suggesting that disruptions in attention and executive function are likely contributors.
Cronin-Golomb, Alice +3 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
npj Parkinson's DiseaseUnderstanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson’s disease (PD) given the architecture of the basal ganglia.
Quyen B. Do +13 more
doaj +1 more source
, 2015 Additional file 2: Table S1. Brain regions with gray matter volume reduction in the patients with Parkinsonâ s disease compared with the healthy control group.
Wei-Che Lin +12 more
openaire +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Additional file 1: of Ceruloplasmin functional changes in Parkinsonâ s disease-cerebrospinal fluid
, 2015 Figure S1. Western blot analysis for contaminant hemoglobin detection. Figure S2. Immunoprecipitation of both resting- and oxidized-ceruloplasmin.Table S1. Spectrophotometric analysis for hemoglobin contaminant detection in CSF samples. (PDF 1445 kb)
Barbariga, Marco +11 more
openaire +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Scientific ReportsWe conducted PET imaging with [18F]FDOPA and dopamine D2/3 receptor ligand [18F]fallypride in aged transgenic rats carrying human pathogenic LRRK2 R1441C or G2019S mutations.
Teresa Delgado-Goñi +12 more
doaj +1 more source
Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles
eLifeThe alpha-synuclein (αSyn) seeding amplification assay (SAA) that allows the generation of disease-specific in vitro seeded fibrils (SAA fibrils) is used as a research tool to study the connection between the structure of αSyn fibrils, cellular seeding ...
Selene Seoyun Lee +2 more
doaj +1 more source
npj Parkinson's Disease, 2022 Drug-induced parkinsonism (DIP) can be clinically indistinguishable from degenerative parkinsonism, and bedside assessments are needed to differentiate between these conditions. We examined 34 U.S.
Whitley W. Aamodt +6 more
doaj +1 more source