Results 41 to 50 of about 263,626 (317)

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

eLife
The alpha-synuclein (αSyn) seeding amplification assay (SAA) that allows the generation of disease-specific in vitro seeded fibrils (SAA fibrils) is used as a research tool to study the connection between the structure of αSyn fibrils, cellular seeding ...
Selene Seoyun Lee, Livia Civitelli, Laura Parkkinen   +2 more
doaj   +1 more source

Gait abnormalities and non-motor symptoms predict abnormal dopaminergic imaging in presumed drug-induced Parkinsonism

npj Parkinson's Disease, 2022
Drug-induced parkinsonism (DIP) can be clinically indistinguishable from degenerative parkinsonism, and bedside assessments are needed to differentiate between these conditions. We examined 34 U.S.
Whitley W. Aamodt, Jacob G. Dubroff, Gang Cheng, Betty Taylor, Stephanie Wood, John E. Duda, James F. Morley   +6 more
doaj   +1 more source

Additional file 2: of Meta-analysis of risk factors for Parkinsonâ s disease dementia

, 2016
Details of the study results. This file provided detailed results of meta-analysis of each risk factor. (DOCX 159 kb)
Xu, Yaqian, Yang, Jing, Shang, Huifang
openaire   +1 more source

The potential role of dietary polyphenols in Parkinson’s disease [PDF]

, 2011
Cumulative evidence now suggests that the abnormal aggregation of the neuronal protein alpha-synuclein is critically involved in the pathogenesis of synucleinopathies, of which Parkinson’s disease (PD) is the most prevalent. Development of neuropathology
Vassallo, Neville, Caruana Grech Perry, Mario   +1 more
core  

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease. [PDF]

, 2014
Unlike most other cell types, neurons preferentially metabolize glucose via the pentose phosphate pathway (PPP) to maintain their antioxidant status. Inhibiting the PPP in neuronal cell models causes cell death.
Allen, GF, Holton, Janice L., Dunn, L, Pope, Simon, Li, A, Lees, A, Li, Abi, Ling, Helen, Lees, Andrew, Allen, George FG., Heales, SJ, Duberley, KE, Hargreaves, Iain P., Dunn, Laura, Allen, George F. G., Mamais, A, Mamais, Adamantios, Bandopadhyay, Rina, Hargreaves, IP, Holton, JL, Bandopadhyay, R, Ling, H, Duberley, Kate E., Pope, S, Heales, Simon J.   +24 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Essential Tremor and Parkinson’s Disease: Exploring the Relationship

Tremor and Other Hyperkinetic Movements, 2019
Background: There is longstanding controversy surrounding the possible link between essential tremor (ET) and Parkinson’s disease (PD). Inconsistent and unreliable diagnostic criteria may in part account for some of the difficulties in defining the ...
Arjun Tarakad, Joseph Jankovic
doaj   +1 more source

Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling

Cells, 2021
Striatal dopamine (DA) release is critical for motivated actions and reinforcement learning, and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here, we review a wealth of historical and more recently refined evidence
Bradley M. Roberts, Emanuel F. Lopes, Stephanie J. Cragg   +2 more
doaj   +1 more source

Additional file 1: of Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinsonâ s disease: what is the impact of Parkinsonâ s disease on surgical outcome?

, 2019
The assessment Scale Proposed by the Japanese Orthopaedic Association. The Japanese Orthopaedic Association Scoring system (JOA score) consists of 2 categories (subjective and objective symptoms), ranging from 0 (worst condition) to 15 (best condition). (DOCX 22 kb)
Watanabe, Kei, Katsumi, Keiichi, Ohashi, Masayuki, Shibuya, Yohei, Izumi, Tomohiro, Hirano, Toru, Endo, Naoto, Kaito, Takashi, Yamashita, Tomoya, Fujiwara, Hiroyasu, Nagamoto, Yukitaka, Matsuoka, Yuji, Suzuki, Hidekazu, Nishimura, Hirosuke, Terai, Hidetomi, Tamai, Koji, Tagami, Atsushi, Yamada, Syuta, Adachi, Shinji, Yoshii, Toshitaka, Ushio, Shuta, Harimaya, Katsumi, Kawaguchi, Kenichi, Yokoyama, Nobuhiko, Oishi, Hidekazu, Doi, Toshiro, Kimura, Atsushi, Inoue, Hirokazu, Inoue, Gen, Miyagi, Masayuki, Saito, Wataru, Nakano, Atsushi, Sakai, Daisuke, Nukaga, Tadashi, Ikegami, Shota, Shimizu, Masayuki, Futatsugi, Toshimasa, Ohtori, Seiji, Furuya, Takeo, Orita, Sumihisa, Imagama, Shiro, Ando, Kei, Kobayashi, Kazuyoshi, Kiyasu, Katsuhito, Murakami, Hideki, Yoshioka, Katsuhito, Seki, Shoji, Hongo, Michio, Kakutani, Kenichiro, Yurube, Takashi, Aoki, Yasuchika, Oshima, Masashi, Takahata, Masahiko, Iwata, Akira, Endo, Hirooki, Abe, Tetsuya, Tsukanishi, Toshinori, Nakanishi, Kazuyoshi, Watanabe, Kota, Hikata, Tomohiro, Suzuki, Satoshi, Isogai, Norihiro, Okada, Eijiro, Funao, Haruki, Ueda, Seiji, Shiono, Yuta, Nojiri, Kenya, Hosogane, Naobumi, Ishii, Ken   +68 more
openaire   +1 more source

A blinded, controlled trial of objective measurement in Parkinson’s disease

, 2020
Medical conditions with effective therapies are usually managed with objective measurement and therapeutic targets. Parkinson’s disease has effective therapies, but continuous objective measurement has only recently become available.
Woodrow, Holly, Winkel, Antony, Fernando, Chathurini V, Kotschet, Katya E, Horne, Malcolm K, et al.   +5 more
core   +1 more source