Results 41 to 50 of about 213,160 (266)

MOESM2 of Prevalence and incidence of Parkinsonâ s disease and drug-induced parkinsonism in Korea

, 2019
Additional file 2: Figure S1. Sensitivity analysis. Incidence of drug-induced parkinsonism in Korea.
Han, Sola, Kim, Siin, Kim, Hyungtae, Shin, Hae-Won, Na, Kyoung-Sae, Suh, Hae Sun   +5 more
openaire   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Additional file 2: of LRRK2 contributes to monocyte dysregulation in Parkinsonâ s disease

, 2019
LRRK2 protein expression is significantly upregulated in monocytes from PD patients. (PDF 303 kb)
Bliederhaeuser, Corinna, Zondler, Lisa, Grozdanov, Veselin, Ruf, Wolfgang, Brenner, David, Melrose, Heather, Bauer, Peter, Ludolph, Albert, Gillardon, Frank, Kassubek, Jan, Weishaupt, Jochen, Danzer, Karin   +11 more
openaire   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

MOESM4 of A randomized controlled efficacy study of the Medido medication dispenser in Parkinsonâ s disease

, 2019
Additional file 4. Table with secondary outcomes of PDQ-carer.
Hannink, K., Brake, L., Oonk, N.G.M., Wertenbroek, A.A., Piek, M., Vree-Egberts, L., Faber, M.J., Palen, J., Dorresteijn, L.D.   +8 more
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Image-guided programming deep brain stimulation improves clinical outcomes in patients with Parkinson’s disease

npj Parkinson's Disease
Deep brain stimulation (DBS) is an effective treatment for patients with Parkinson’s disease (PD). However, some patients may not respond optimally to clinical programming adjustments.
Viviana Torres, Kirsys Del Giudice, Pedro Roldán, Jordi Rumià, Esteban Muñoz, Ana Cámara, Yaroslau Compta, Almudena Sánchez-Gómez, Francesc Valldeoriola   +8 more
doaj   +1 more source

Live Imaging of Axonal Transport in the Motor Neurons of Drosophila Larvae

Bio-Protocol, 2017
Axonal transport, which is composed of microtubules, motor proteins and a variety of types of cargo, is a prominent feature of neurons. Monitoring these molecular dynamics is important to understand the biological processes of neurons as well as ...
Tsuyoshi Inoshita, Nobutaka Hattori, Yuzuru Imai   +2 more
doaj   +1 more source

Additional file 1: of LRRK2 contributes to monocyte dysregulation in Parkinsonâ s disease

, 2019
Supplementary materials and methods. (PDF 1185 kb)
Bliederhaeuser, Corinna, Zondler, Lisa, Grozdanov, Veselin, Ruf, Wolfgang, Brenner, David, Melrose, Heather, Bauer, Peter, Ludolph, Albert, Gillardon, Frank, Kassubek, Jan, Weishaupt, Jochen, Danzer, Karin   +11 more
openaire   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source