Results 31 to 40 of about 263,626 (317)

Additional file 3: of Meta-analysis of risk factors for Parkinsonâ s disease dementia

, 2016
Details of factors not included in the meta-analysis. This file provided data of risk factors for Parkinsonâ s disease dementia that were mentioned in literature, but were not included in the meta-analysis due to limited number of studies or differences in study design. (DOCX 93 kb)
Yaqian Xu, Yang, Jing, Huifang Shang
openaire   +1 more source

Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

, 2023
Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis
the 23andMe Research Team; the Global Parkinson’s Genetics Program (GP2), Bielenberg, Jessica, Aslibekyan, Stella, Kim, Jonggeol Jeffrey, Babalola, Elizabeth, Bell, Robert K., Mata, Ignacio, Vitale, Dan, Auton, Adam, Lian, Michelle Mulan, Otani, Diego Véliz, Heilbron, Karl   +11 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation

npj Parkinson's Disease
Understanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson’s disease (PD) given the architecture of the basal ganglia.
Quyen B. Do, Humaira Noor, Ricardo Marquez-Gomez, Kaitlyn M. L. Cramb, Bryan Ng, Ajantha Abbey, Naroa Ibarra-Aizpurua, Maria Claudia Caiazza, Parnaz Sharifi, Charmaine Lang, Dayne Beccano-Kelly, Jimena Baleriola, Nora Bengoa-Vergniory, Richard Wade-Martins   +13 more
doaj   +1 more source

MOESM2 of Brain mediators of systemic oxidative stress on perceptual impairments in Parkinsonâ s disease

, 2015
Additional file 2: Table S1. Brain regions with gray matter volume reduction in the patients with Parkinsonâ s disease compared with the healthy control group.
Wei-Che Lin, Kun-Hsien Chou, Lee, Pei-Lin, Yung-Cheng Huang, Nai-Wen Tsai, Hsiu-Ling Chen, Kuei-Yueh Cheng, Hung-Chen Wang, Tsu-Kung Lin, Shau-Hsuan Li, Meng-Hsiang Chen, Cheng-Hsien Lu, Ching-Po Lin   +12 more
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Additional file 1: of Ceruloplasmin functional changes in Parkinsonâ s disease-cerebrospinal fluid

, 2015
Figure S1. Western blot analysis for contaminant hemoglobin detection. Figure S2. Immunoprecipitation of both resting- and oxidized-ceruloplasmin.Table S1. Spectrophotometric analysis for hemoglobin contaminant detection in CSF samples. (PDF 1445 kb)
Barbariga, Marco, Curnis, Flavio, Annapaola Andolfo, Zanardi, Alan, Lazzaro, Massimo, Conti, Antonio, Magnani, Giuseppe, Volontè, Maria, Ferrari, Laura, Comi, Giancarlo, Corti, Angelo, Alessio, Massimo   +11 more
openaire   +1 more source

Mitochondrial dysfunction in Parkinson's disease : pathogenesis and neuroprotection [PDF]

, 2011
Peer ...
Teismann, Peter, Mounsey, Ross B, Ross B. Mounsey, Peter Teismann   +3 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson’s disease revealed by in vivo PET imaging

Scientific Reports
We conducted PET imaging with [18F]FDOPA and dopamine D2/3 receptor ligand [18F]fallypride in aged transgenic rats carrying human pathogenic LRRK2 R1441C or G2019S mutations.
Teresa Delgado-Goñi, Natalie Connor-Robson, Milena Cioroch, Stephen Paisey, Christopher Marshall, Emma L. Lane, David Hauton, James McCullagh, Peter J. Magill, Stephanie J. Cragg, Clare E. Mackay, Richard Wade-Martins, Johannes C. Klein   +12 more
doaj   +1 more source