Results 51 to 60 of about 213,160 (266)

Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities

Translational Neurodegeneration, 2019
The fundamental role that alpha-synuclein (aSyn) plays in the pathogenesis of neurodegenerative synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, is a well-accepted fact.
Naomi P. Visanji, Anthony E. Lang, Gabor G. Kovacs   +2 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Effect of dopamine on limbic network connectivity at rest in Parkinson’s disease patients with freezing of gait

Translational Neuroscience
Freezing of gait (FOG) in Parkinson’s disease (PD) has a poorly understood pathophysiology, which hinders treatment development. Recent work showed a dysfunctional fronto-striato-limbic circuitry at rest in PD freezers compared to non-freezers in the ...
Quek Dione Y. L., Taylor Natasha, Gilat Moran, Lewis Simon J. G., Ehgoetz Martens Kaylena A.   +4 more
doaj   +1 more source

TIA1 Mutant Mouse Model Exhibits Motor Deficits and Neurodegenerative Characteristics of Amyotrophic Lateral Sclerosis

Cells
Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that primarily affects the motor neurons. T cell intracellular antigen 1 (TIA1) is a risk gene for ALS pathogenesis. To elucidate TIA1-mediated disease mechanisms,
Li-Hong Mao, Yu-Ning Song, Jing-Qi Zhang, Yun-Ting Shao, Zhang-Li Wang, Na Yang, Wen-Xuan Zhang, Ying-Rui Zhang, Xiao-Yan Gao, Jia-Yi Li, Lin Yuan   +10 more
doaj   +1 more source

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

Nature Communications, 2020
The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.
Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M. Caffrey, Jimena Monzón-Sandoval, Rory Bowden, Javier Alegre-Abarrategui, Richard Wade-Martins, Caleb Webber   +8 more
doaj   +1 more source

Additional file 6: of Blood transcriptomics of drug-naĂŻve sporadic Parkinsonâ s disease patients

, 2015
List of differentially expressed genes between PD patients and controls based on PUMA. Ratios are calculated as differences in gene expression between samples of PD patients and controls, with the top up-regulated genes first. (PDF 3122 kb)
Calligaris, Raffaella, Banica, Mihaela, Roncaglia, Paola, Robotti, Elisa, Finaurini, Sara, Vlachouli, Christina, Antonutti, Lucia, Iorio, Francesco, Carissimo, Annamaria, Cattaruzza, Tatiana, Ceiner, Andrea, Lazarevic, Dejan, Cucca, Alberto, Pangher, Nicola, Marengo, Emilio, Bernardo, Diego di, Pizzolato, Gilberto, Gustincich, Stefano   +17 more
openaire   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Additional file 10: of Blood transcriptomics of drug-naĂŻve sporadic Parkinsonâ s disease patients

, 2015
List of common genes between A9 DA neurons of the SN in the mouse and differentially expressed transcripts in the blood of PD patients according to SAM (a) and PUMA (b). (PDF 3122 kb)
Calligaris, Raffaella, Banica, Mihaela, Roncaglia, Paola, Robotti, Elisa, Finaurini, Sara, Vlachouli, Christina, Antonutti, Lucia, Iorio, Francesco, Carissimo, Annamaria, Cattaruzza, Tatiana, Ceiner, Andrea, Lazarevic, Dejan, Cucca, Alberto, Pangher, Nicola, Marengo, Emilio, Bernardo, Diego Di, Pizzolato, Gilberto, Gustincich, Stefano   +17 more
openaire   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source