Results 51 to 60 of about 263,626 (317)

PET Studies of Cerebral Levodopa Metabolism: A Review of Clinical Findings and Modeling Approaches [PDF]

, 2009
[18F]Fluoro-3,4-dihydroxyphenyl-l-alanine (FDOPA) was one of the first successful tracers for molecular imaging by positron emission tomography (PET), and has proven immensely valuable for studies of Parkinson’s disease.
Kumakura, Yoshitaka, Yoshitaka Kumakura, Paul Cumming, Cumming, Paul   +3 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

MOESM1 of Brain mediators of systemic oxidative stress on perceptual impairments in Parkinsonâ s disease

, 2015
Additional file 1. Detail T1-weighted structural MRI image processing procedures.
Lin, Wei-Che, Chou, Kun-Hsien, Lee, Pei-Lin, Huang, Yung-Cheng, Tsai, Nai-Wen, Chen, Hsiu-Ling, Cheng, Kuei-Yueh, Wang, Hung-Chen, Lin, Tsu-Kung, Li, Shau-Hsuan, Chen, Meng-Hsiang, Lu, Cheng-Hsien, Lin, Ching-Po   +12 more
openaire   +1 more source

AN EXAMINATION OF CONCURRENT DISCRIMINATION LEARNING WITHIN INDIVIDUALS WITH PARKINSON’S DISEASE [PDF]

, 2013
The main focus of this research is to further understand memory formation by examining the role of the basal ganglia in learning. Broadly, this study examines how the basal ganglia may play a role in a task that has been associated with declarative ...
Tuladhar, Darshana
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Additional file 1: of Meta-analysis of risk factors for Parkinsonâ s disease dementia

, 2016
Details of studies included in the meta-analysis. This file included details of all studies included in this meta-analysis, categorized by risk factors. Details including first author, year of publication, country, study design, number of participants and NOS scores. (DOCX 119 kb)
Xu, Yaqian, Yang, Jing, Shang, Huifang
openaire   +1 more source

Beyond the clinical aspects: the social implications of Parkinson’s disease

, 2022
From a clinical standpoint, Parkinson’s disease (PD) is a severe, disabling neurodege-nerative disorder characterised by a progressive and chronic disturbance, mainly (though not exclusively) affecting movement control and balance (Poewe et al., 2017 ...
Lombi L.
core  

A proposal for a comprehensive grading of Parkinson's disease severity combining motor and non-motor assessments: meeting an unmet need. [PDF]

, 2013
Non-motor symptoms are present in Parkinson's disease (PD) and a key determinant of quality of life. The Non-motor Symptoms Scale (NMSS) is a validated scale that allows quantifying frequency and severity (burden) of NMS.
Brown, Richard J., Jose Manuel Rojo (382888), Stocchi, Fabrizio, Chaudhuri, Kallol Ray, Martinez-Martin, Pablo, Richard J. Brown (382891), David J. Brooks (316043), Brooks, David J., Ray Chaudhuri, K, Antonini, A, Kallol Ray Chaudhuri, Stocchi, F, Schapira, Anthony H. V., Richard G Brown, Brooks, David J, Anthony H. V. Schapira (139480), Fabrizio Stocchi (382889), Odin, Per, Martinez-Martin, P, Rojo, JM, Schapira, AH, Anthony H V Schapira, Fabrizio Stocchi, Per Odin (382890), Antonini, Angelo, Odin, P, Brooks, DJ, Kallol Ray Chaudhuri (382887), David J Brooks, Pablo Martinez-Martin, Odin, Per,, Manuel Rojo, Jose, Ray Chaudhuri, Kallol, Brown, RJ, Rojo, Jose Manuel, Pablo Martinez-Martin (3179352), Schapira, Anthony H V, Brown, Richard J.; id_orcid, Jose Manuel Rojo, Per Odin, Angelo Antonini (222327), Lund University., Angelo Antonini   +42 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Image-guided programming deep brain stimulation improves clinical outcomes in patients with Parkinson’s disease

npj Parkinson's Disease
Deep brain stimulation (DBS) is an effective treatment for patients with Parkinson’s disease (PD). However, some patients may not respond optimally to clinical programming adjustments.
Viviana Torres, Kirsys Del Giudice, Pedro Roldán, Jordi Rumià, Esteban Muñoz, Ana Cámara, Yaroslau Compta, Almudena Sánchez-Gómez, Francesc Valldeoriola   +8 more
doaj   +1 more source