Results 21 to 30 of about 5,079,684 (260)

How Cognition and Motivation “Freeze” the Motor Behavior in Parkinson’s Disease

Frontiers in Neuroscience, 2019
ObjectiveFreezing of gait (FoG) is a debilitating problem in patients with PD. The multifactorial pathogenesis of FoG remains poorly understood. We aimed to find which factors are most strongly associated with the occurrence of FoG.MethodsThree hundred ...
Paola Ortelli, Davide Ferrazzoli, Veronica Cian, Veronica Cian, Marianna Zarucchi, Grazia Palamara, Alessandro Giobbia, Giuseppe Frazzitta, Roberto Maestri, Margherita Canesi   +9 more
doaj   +1 more source

Parkinson's disease - psychological determinants of quality of life [PDF]

, 2010
There are many studies, which are focused on measurement the quality of life (QoL) of patients with Parkinson’s disease (PD), but studies about psychological factors associated with QoL in those patients are scarce.
Dubayova, Tatiana,, Dubayova, Tatiana
core   +17 more sources

Does cueing training improve physical activity in patients with Parkinson's disease? [PDF]

, 2010
Patients with Parkinson’s disease (PD) are encouraged to stay active to maintain their mobility. Ambulatory activity monitoring (AM) provides an objective way to determine type and amount of gait-related daily activities.
Lim - de Vries, L.I.I.K., Nieuwboer, Alice, Willems, A.M., Hetherington, V., Wegen, E.E.H. van, van Wegen, E.E.H., Lim, Inge, Kwakkel, Gert, Rochester, Lynn, Jones, D., Lim-de Vries, L.I.I.K., Jones, Diana, Rochester, L., van Wegen, Erwin, Baker, Katherine, Baker, K., Nieuwboer, A., Hetherington, Victoria, Willems, Anne-Marie, Kwakkel, G.   +19 more
core   +1 more source

Measuring anxiety in Lewy Body Disease – Which scale to choose?

Clinical Parkinsonism & Related Disorders, 2021
Background: Anxiety is among the most prevalent mood disorders in Lewy Body Disease (LBD) (i.e., Parkinson’s disease (PD), Dementia with Lewy bodies DLB), and those at-risk for developing LBD (e.g. isolated REM Sleep Behaviour Disorder (iRBD)).
Isabel Paniak, Simon J.G. Lewis, Kaylena A. Ehgoetz Martens   +2 more
doaj   +1 more source

Auditory observation of stepping actions can cue both spatial and temporal components of gait in Parkinson's disease patients [PDF]

, 2014
Objectives: A common behavioural symptom of Parkinson’s disease (PD) is reduced step length (SL). Whilst sensory cueing strategies can be effective in increasing SL and reducing gait variability, current cueing strategies conveying spatial or temporal ...
Young, William R., Rodger, Matthew W. M.; id_orcid, Rodger, MWM, Craig, CM, Rodger, Matthew W.M., Craig, Cathy M., Young, WR   +6 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Cognitive impairment in Parkinson's disease : is it a unified phenomenon? [PDF]

, 2005
Parkinson's disease (PD) has long been associated with dementia. This has been found to correlate with participant age, age at onset of PD and severity of PD.
Lowit, Anja, Howell, Peter, Brendel, Bettina   +2 more
core   +4 more sources

Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation

npj Parkinson's Disease
Understanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson’s disease (PD) given the architecture of the basal ganglia.
Quyen B. Do, Humaira Noor, Ricardo Marquez-Gomez, Kaitlyn M. L. Cramb, Bryan Ng, Ajantha Abbey, Naroa Ibarra-Aizpurua, Maria Claudia Caiazza, Parnaz Sharifi, Charmaine Lang, Dayne Beccano-Kelly, Jimena Baleriola, Nora Bengoa-Vergniory, Richard Wade-Martins   +13 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Morphological changes of glutamatergic synapses in animal models of Parkinson’s disease

Frontiers in Neuroanatomy, 2015
The striatum and the subthalamic nucleus are the main entry doors for extrinsic inputs to reach the basal ganglia circuitry. The cerebral cortex, thalamus and brainstem are the key sources of glutamatergic inputs to these nuclei.
Rosa M Villalba, Rosa M Villalba, Abraham eMathai, Abraham eMathai, Yoland eSmith, Yoland eSmith, Yoland eSmith   +6 more
doaj   +1 more source