Results 21 to 30 of about 457,449 (311)

Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease [PDF]

, 2017
5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains.
F Shephard, K Lunnon, KE Szulwach, M Mellen, RS Illingworth, S Horvath, S Shpyleva, S Starkstein, SF Field, T Wu, TF Kraus   +10 more
core   +2 more sources

How Cognition and Motivation “Freeze” the Motor Behavior in Parkinson’s Disease

Frontiers in Neuroscience, 2019
ObjectiveFreezing of gait (FoG) is a debilitating problem in patients with PD. The multifactorial pathogenesis of FoG remains poorly understood. We aimed to find which factors are most strongly associated with the occurrence of FoG.MethodsThree hundred ...
Paola Ortelli, Davide Ferrazzoli, Veronica Cian, Veronica Cian, Marianna Zarucchi, Grazia Palamara, Alessandro Giobbia, Giuseppe Frazzitta, Roberto Maestri, Margherita Canesi   +9 more
doaj   +1 more source

Drug Repurposing for Parkinson’s Disease: The International Linked Clinical Trials experience

Frontiers in Neuroscience, 2021
The international Linked Clinical Trials (iLCT) program for Parkinson’s to date represents one of the most comprehensive drug repurposing programs focused on one disease.
Simon R. W. Stott, Richard K. Wyse, Patrik Brundin   +2 more
doaj   +1 more source

Physiotherapy intervention in Parkinson's disease: systematic review and meta-analysis [PDF]

, 2012
Objective To assess the effectiveness of physiotherapy compared with no intervention in patients with Parkinson’s disease. Design Systematic review and meta-analysis of randomised controlled trials.
Clarke, Carl E., Deane, Katherine H. O., Herd, Clare P., Ives, Natalie, Meek, Charmaine, Patel, Smitaa, Sackley, Catherine, Shah, Laila, Stowe, Rebecca, Tomlinson, Claire L., Wheatley, Keith   +10 more
core   +1 more source

Abnormal connectivity between the default mode and the visual system underlies the manifestation of visual hallucinations in Parkinson’s disease:A task-based fMRI study [PDF]

, 2015
Background: The neural substrates of visual hallucinations remain an enigma, due primarily to the difficulties associated with directly interrogating the brain during hallucinatory episodes.
Halliday, Glenda M., Hornberger, Michael, Lewis, Simon J. G., Muller, Alana J., O’Callaghan, Claire, Shine, James M.   +5 more
core   +1 more source

Predictors of functional dependency in Parkinson’s disease [PDF]

, 2016
Financial disclosures/conflicts of interest: Dr Macleod was funded by a Clinical Academic Fellowship from the Chief Scientist Office of the Scottish Government and received grant funding from Parkinson’s UK, the Wellcome Trust, University of Aberdeen ...
Adler, Alves, Auyeung, Bello-Haas, Caslake, Caslake, Charlson, Forjaz, Grambsch, Groot, Guillard, Hernan, Hughes, Jankovic, Jasinska-Myga, Kaczynski, Macleod, Macleod, Macleod, Martinez-Martin, McCloone, McRae, Morley, Peduzzi, Quik, Riley, Royston, Schwab, Scigliano, Shah, Steyerberg, Taylor, Velseboer, Wade   +33 more
core   +1 more source

ANN for Parkinson’s Disease Prediction [PDF]

, 2020
Parkinson's Disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time.
Abdul Ghattas, Majed, Abunbehan, Abdul Karim, Badawi, Mohamed, Mohammed, Abdul, Sadek, Salah   +4 more
core  

Palliative care for Parkinson's disease: Patient and carer's perspectives explored through qualitative interview [PDF]

, 2018
Background: Palliative care is recommended for non-malignant illnesses, including Parkinson’s disease. However, past research with healthcare workers highlights unmet palliative needs in this population and referral rates to Specialist Palliative Care ...
Cashell, Alison, Foley, Mary J., Fox, Siobhán, Kernohan, W. George, Lynch, Marie, McGlade, Ciara, O'Brien, Tony, O'Sullivan, Sean S., Timmons, Suzanne   +8 more
core   +1 more source

Additional file 2: of Responsiveness of the short-form health survey and the Parkinsonâ s disease questionnaire in patients with Parkinsonâ s disease

, 2017
Internal responsiveness of HRQoL in the stable patient group. (DOCX 20 kb)
Tu, Xiao-Jing, Wen-Juh Hwang, Shih-Pin Hsu, Hui-Ing Ma   +3 more
openaire   +1 more source

Protective potential of glucagon like peptide 2 (GLP-2) against the neurodegeneration [PDF]

, 2019
Neurodegeneration consists in loss of neuron specific types, pattern and distribution, leading to progressive dysfunctions of the central nervous system.
Amato, Antonella, Mulè, Flavia
core   +1 more source