Results 121 to 130 of about 457,449 (311)

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Additional file 1: of Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinsonâ s disease

, 2016
Supplementary Materials and Methods. (PDF 401Â kb)
Majbour, Nour, Vaikath, Nishant, van Dijk, Karin, Ardah, Mustafa, Varghese, Shiji, Vesterager, Louise, Montezinho, Liliana, Poole, Stephen, Safieh-Garabedian, Bared, Tokuda, Takahiko, Teunissen, Charlotte, Berendse, Henk, van de Berg, Wilma, El-Agnaf, Omar   +13 more
openaire   +1 more source

Costs of Parkinson's Disease and Antiparkinsonian Pharmacotherapy: An Italian Cohort Study [PDF]

, 2010
Objective: Antiparkinsonian pharmacotherapy is costly and the determinants of drug costs in Parkinson's disease (PD) have been poorly investigated. The objective of this study was to investigate the costs of PD and antiparkinsonian drugs in an Italian ...
Balzer-Geldsetzer, Monika, Barone, Paolo, Bötzel, Kai, Campenhausen, Sonja von, Dodel, Richard, Eggert, Karla, Longo, Katia, Oertel, Wolfgang H., Reese, Jens P., Spiga, Giuseppe, Winter, Yaroslav   +10 more
core   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source

Additional file 2: of The association between Parkinsonâ s disease and melanoma: a systematic review and meta-analysis

, 2015
Quality assessment of studies included in the Meta-analysis. Criterion include five parts: 1) definition of PD diagnosis; 2) validation of PD diagnosis; 3) adjustment for confounding factors; 4) source and definition of cancer diagnoses; 5) representativeness of cases. Potential total scores ranged from 0 to 9. (PDF 127 kb)
Huang, Pei, Yang, Xiao-Dong, Chen, Sheng-Di, Xiao, Qin   +3 more
openaire   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

EMPOWER-PD - A physical therapy intervention to empower the individuals with Parkinson’s disease: a study protocol for a feasibility randomized controlled trial

Pilot and Feasibility Studies, 2019
Background One of the greatest barriers found by physical therapy treating individuals with Parkinson’s disease (PD) is the adherence to treatment, associated with the lack of motivation to remain active.
Helena de Oliveira Braga, Elaine Cristina Gregório, Rafaela Simon Myra, Ana Sofia Kauling de Souza, Talita Vitorina Kunh, Jessica Klug, Adriana Coutinho de Azevedo Guimarães, Alessandra Swarowsky   +7 more
doaj   +1 more source

Additional file 1: of The association between Parkinsonâ s disease and melanoma: a systematic review and meta-analysis

, 2015
Characteristics of studies included in the Meta-analysis. Including information of first author, year of publication, country, study design, number of patients and controls, duration of follow-up. (PDF 74 kb)
Huang, Pei, Yang, Xiao-Dong, Chen, Sheng-Di, Xiao, Qin   +3 more
openaire   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Recent Advances in Understanding and Managing Tourette Syndrome [version 1; referees: 3 approved]

F1000Research, 2016
Tourette syndrome (TS) is a neurologic and behavioral disorder consisting of motor and phonic tics with onset in childhood or adolescence. The severity of tics can range from barely perceptible to severely impairing due to social embarrassment ...
Mary Ann Thenganatt, Joseph Jankovic
doaj   +1 more source