Results 121 to 130 of about 213,535 (253)

CPP–PEG‐Guided Surface Engineering of Mitochondria Enables Efficient Cellular Uptake and Respiratory Modulation

Advanced Materials Interfaces, EarlyView.
PEG‐guided mitochondrial surface engineering supports structural stabilization and controlled presentation of cell‐penetrating peptides. CPP–PEG‐modified mitochondria exhibit enhanced cellular uptake and uptake‐associated respiratory modulation, providing a proof‐of‐concept framework for modular organelle engineering and future bioenergetic modulation ...
Masahiro Shiraishi, Yukari Muramatsu, Akihiro Nakaya, Yuji Maruo, Rick C. Tsai, Masashi Suganuma, Hisashi Ohta, Atsuhito Takeda, Hideyoshi Harashima, Yuma Yamada   +9 more
wiley   +1 more source

Knowledge mapping of ferroptosis in Parkinson’s disease: a bibliometric analysis: 2012–2023

Frontiers in Aging Neuroscience
BackgroundFerroptosis is a crucial pathogenic mechanism in Parkinson’s disease, offering significant potential for pharmacological intervention. Despite its importance, the number of bibliometric analyses examining the relationship between ferroptosis ...
Juanqin Li, Juanqin Li, Yanli Wang, Yanli Wang, Jing Huang, Jing Huang, Daokai Gong, Daokai Gong   +7 more
doaj   +1 more source

Additional file 1: of Nicotine promotes neuron survival and partially protects from Parkinsonâ s disease by suppressing SIRT6

, 2018
Figure S1. Human brain tissue analysis by SDS-PAGE. Figure S2. Cigarette smoke extract apparatus, nicotine blots, and proteasome activity. Figure S3. Transgenic mice and brain expression. Figure S4. SIRT6 OX neurons secrete more TNFÎą than WT. Figure S5. Primary neuronal culture composition. Figure S6.
Nicholatos, Justin, Francisco, Adam, Bender, Carolyn, Yeh, Tiffany, Lugay, Fraz, Salazar, Jairo, Glorioso, Christin, Libert, Sergiy   +7 more
openaire   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Epidemiology of Tourette Syndrome

Brain Sciences
Background/Objectives: Tourette syndrome (TS) is a neurodevelopmental disorder, manifested by tics and a variety of behavioral comorbidities that cluster strongly within families, suggesting a combination of genetic and environmental risk factors.
Abdullah Yasir Yilmaz, Joseph Jankovic
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Simple and Complex Phonic Tics in Tourette Syndrome

Brain Sciences
Tourette syndrome (TS) is the most common cause of tics. Tics are classified as motor and phonic tics. The latter (previously also referred to as “vocal tics”) are manifested by simple sounds (simple phonic tics) or complex, often semantically meaningful
José Fidel Baizabal-Carvallo, Joseph Jankovic   +1 more
doaj   +1 more source

Additional file 1: of Identification of plasma microRNA expression changes in multiple system atrophy and Parkinsonâ s disease

, 2019
Table S1. miRNAs with significantly higher and lower expression compared to healthy controls in microarray analysis. (DOCX 38 kb)
Uwatoko, Hisashi, Hama, Yuka, Iwata, Ikuko, Shirai, Shinichi, Matsushima, Masaaki, Yabe, Ichiro, Utsumi, Jun, Sasaki, Hidenao   +7 more
openaire   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

Multimodal oculomotor assessment reveals prodromal markers of Parkinson’s disease in non-manifesting LRRK2 G2019S mutation carriers

npj Parkinson's Disease
Oculomotor behaviour changes in patients with Parkinson’s disease (PD) are a promising source of prodromal disease markers. Capitalizing on this phenomenon to facilitate early diagnosis requires oculomotor assessment in prodromal cohorts.
Heidi C. Riek, Naomi P. Visanji, Isabell C. Pitigoi, Daniel G. Di Luca, Laura Armengou-Garcia, Nazish Ahmed, Julia E. Perkins, Donald C. Brien, Jeff Huang, Brian C. Coe, Jana Huang, Taneera Ghate, Anthony E. Lang, Connie Marras, Douglas P. Munoz   +14 more
doaj   +1 more source