Results 81 to 90 of about 9,678,735 (383)

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease

Nature Genetics, 2014
We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and
M. Nalls, N. Pankratz, C. Lill, Chuong B. Do, D. Hernandez, D. Hernandez, M. Saad, M. Saad, M. Saad, A. Destefano, A. Destefano, E. Kara, J. Bras, Manu Sharma, C. Schulte, Margaux F. Keller, S. Arepalli, Christopher T Letson, Connor Edsall, H. Stefánsson, Xinmin Liu, Hannah A. Pliner, Joseph H. Lee, R. Cheng, M. Ikram, J. Ioannidis, G. Hadjigeorgiou, J. Bis, Miguel Ángel Martínez, Miguel Ángel Martínez, J. Perlmutter, A. Goate, K. Marder, B. Fiske, Margaret Sutherland, G. Xiromerisiou, R. Myers, L. Clark, K. Stefánsson, J. Hardy, P. Heutink, Honglei Chen, N. Wood, H. Houlden, H. Payami, A. Brice, A. Brice, W. Scott, T. Gasser, L. Bertram, N. Eriksson, T. Foroud, A. Singleton   +52 more
semanticscholar   +1 more source

Freezing of Gait in Parkinson’s Disease: A Perceptual Cuase for a Motor Impairment? [PDF]

, 2009
While freezing of gait (FOG) is typically considered a motor impairment, the fact that it occurs more frequently in confined spaces suggests that perception of space might contribute to FOG.
Almeida, Quincy J., Lebold, Chad A.
core   +1 more source

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]

, 2017
Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S., Chatterjee, U., Ganguly, G., Saso, L.   +3 more
core   +3 more sources

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan, Stephanie A. Chu, Suvi Häkkinen, Liwen Zhang, David McFall, Jonathan D. Rohrer, Jesse A. Brown, Alex J. Lee, Kristen Fernhoff, Lorenzo Pasquini, Katherine P. Rankin, Maria Luisa Mandelli, Maria Luisa Gorno‐Tempini, Jennifer S. Yokoyama, Virginia E. Sturm, Brian Appleby, Bradford C. Dickerson, Kimiko Domoto‐Reilly, Tatiana Foroud, Daniel H. Geschwind, Nupur Ghoshal, Neill R. Graff‐Radford, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward Huey, Kejal Kantarci, Irene Litvan, Ian R. Mackenzie, Mario F. Mendez, Chiadi U. Onyike, Leonard Petrucelli, Eliana Marisa Ramos, Erik D. Roberson, Julio C. Rojas, Maria Carmela Tartaglia, Arthur W. Toga, Sandra Weintraub, Leah K. Forsberg, Hilary W. Heuer, Brad F. Boeve, Adam L. Boxer, Howard J. Rosen, Bruce L. Miller, Fermin Moreno, William W. Seeley, Suzee E. Lee, on behalf of the ALLFTD Consortium   +46 more
wiley   +1 more source

Additional file 3: of Meta-analysis of risk factors for Parkinsonâ s disease dementia

, 2016
Details of factors not included in the meta-analysis. This file provided data of risk factors for Parkinsonâ s disease dementia that were mentioned in literature, but were not included in the meta-analysis due to limited number of studies or differences in study design. (DOCX 93 kb)
Yaqian Xu, Yang, Jing, Huifang Shang
openaire   +1 more source

Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease

Nature Genetics, 2009
We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the ...
J. Simón-Sánchez, C. Schulte, J. Bras, Manu Sharma, J. R. Gibbs, Daniela Berg, C. Paisán-Ruiz, Peter Lichtner, S. Scholz, Dena G. Hernandez, R. Krüger, Monica Federoff, C. Klein, A. Goate, J. Perlmutter, Michael Bonin, Mike A. Nalls, T. Illig, C. Gieger, H. Houlden, M. Steffens, M. S. Okun, B. Racette, M. Cookson, K. Foote, Hubert H. Fernandez, Bryan J Traynor, S. Schreiber, S. Arepalli, Ryan R. Zonozi, Katrina Gwinn, M. V. D. Brug, Grisel Lopez, S. Chanock, A. Schatzkin, Yikyung Park, A. Hollenbeck, Jianjun Gao, Xuemei Huang, Nick W. Wood, D. Lorenz, G. Deuschl, Honglei Chen, Olaf Riess, John Hardy, A. Singleton, T. Gasser   +46 more
semanticscholar   +1 more source

Practice Recommendations for Genetic Testing of Ataxias

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan, Amy D. Mook, Michelle Rochman, Jin Yun Helen Chen, Weiyi Mu, George R. Wilmot, Liana S. Rosenthal, Wendy R. Uhlmann   +7 more
wiley   +1 more source

Integrating technology into a successful apomorphine delivery program in Thailand: a 10-year journey of achievements with a five-motto concept

Frontiers in Neurology
IntroductionApomorphine, a potent dopamine agonist, is a therapeutic option for patients with Parkinson’s disease and motor fluctuations. However, the adoption of and adherence to this therapy have been limited by the need for complex delivery devices ...
Onanong Phokaewvarangkul, Nithinan Kantachadvanich, Vijittra Buranasrikul, Kanyawat Sanyawut, Saisamorn Phumphid, Chanawat Anan, Roongroj Bhidayasiri, Roongroj Bhidayasiri   +7 more
doaj   +1 more source

Asymmetric Dopaminergic Degeneration and Attentional Resources in Parkinson’s Disease

Frontiers in Neuroscience, 2018
Background: Attention is crucial to voluntary perform actions in Parkinson’s disease (PD), allowing patients to bypass the impaired habitual motor control.
Paola Ortelli, Davide Ferrazzoli, Marianna Zarucchi, Roberto Maestri, Giuseppe Frazzitta   +4 more
doaj   +1 more source

Additional file 1: of Meta-analysis of risk factors for Parkinsonâ s disease dementia

, 2016
Details of studies included in the meta-analysis. This file included details of all studies included in this meta-analysis, categorized by risk factors. Details including first author, year of publication, country, study design, number of participants and NOS scores. (DOCX 119 kb)
Yaqian Xu, Yang, Jing, Huifang Shang
openaire   +1 more source